Evoked potentials, reaction time and cognitive performance in on and off phases of Parkinson's disease.

Starkstein, S.; Esteguy, M.; Berthier, Marcelo L.; García, Hernando Santamaría; Leiguarda, R

doi:10.1136/jnnp.52.3.338

Cited by 74 publications

(30 citation statements)

References 7 publications

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“…In most of the studies on levodopa effects, nevermedicated PD patients or patients who underwent a drug washout period (12 h -14 days) were tested on an oddball procedure, first off and then on medication. We identified nine studies employing such a study design with five of them demonstrating a reduction of P3b latency following levodopa administration (Lukhanina et al, 2009;Oishi et al, 1996;Sohn et al, 1998;Stanzione et al, 1991;Starkstein et al, 1989). However, P3b latency was not significantly decreased by levodopa in the studies by Chia et al (1995), Kobayashi et al (2004), and Mathis et al (2014) and even increased under levodopa in the study by Prasher and Findley (1991).…”

Section: P3b and Dopaminergic Medication In Pdmentioning

confidence: 99%

Event-related potentials and cognition in Parkinson’s disease: An integrative review

Seer

Lange

Georgiev

et al. 2016

Neuroscience & Biobehavioral Reviews

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Section: P3b and Dopaminergic Medication In Pdmentioning

confidence: 99%

Event-related potentials and cognition in Parkinson’s disease: An integrative review

Seer

Lange

Georgiev

et al. 2016

Neuroscience & Biobehavioral Reviews

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“…To summarize the findings, after an administration of L-dopa, P3 latency was shortened parallel to RT only in patients with longstanding PD who, eventually, were suffering from motor fluctuations (Starkstein et al, 1989;Stanzione et al, 1991). On the contrary, in younger patients with early PD, the P3 wave was delayed after L-dopa administration (Prasher and Findley, 1991).…”

Section: Erp Correlates Of Physiopathological Mechanisms In Pomentioning

confidence: 99%

“…Starkstein et al (1989) patients suffering from severe motor fluctuations, all of them being treated by L-dopa. The ERP recording was done twice in the same day-when the patients were "off' after an overnight withdrawal of the drug, and when optimal motor status ("on") was reached after reintroduction of the treatment.…”

Section: Erpano Oopaminergic Treatment In Pomentioning

confidence: 99%

Event-Related Potentials in Parkinson’s Disease: A Review

Růžička

Massioui²

1993

Behavioural Neurology

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This article reviews the findings of event-related potentials (ERP) in Parkinson's disease (PD) published during the last 10 years. Basic principles and methods ofERP are briefly presented with particular regard to the auditory "odd-ball" paradigm almost uniquely employed for the ERP assessment in PD to date. The results of respective studies are overviewed and discussed with respect to three main axes:(1) The slowing down of cognitive processing in PD is reflected by the delays ofN2 and P3 components of ERP which are more important in demented than in non-demented patients. The Nl component is delayed in demented patients with PD as well as in other dementias of presumed subcortical origin. (2) Various neuropsychological deficits observed in PD correlate with the delays of ERP evoking the implication of common subcortico-cortical cerebral mechanisms. (3) The variations ofERP under dopaminergic manipulation suggest conflicting effects oflevodopa treatment on cognition, at least in certain categories of PD patients. These findings are discussed in the light of current knowledge on neurotransmitter brain systems and some hypothetic explanations are proposed. Finally, an attempt is made to outline further perspectives of clinical and research utilization of ERP in Parkinson's disease.

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“…Так, S. Starkstein и соавт. [23], а также D. Prasher и L. Findley [24] установили, что у пациентов после приема леводопы латентность пика Р300 существен-но уменьшается. Аналогичные данные получены и в исследовании P. Stanzione и соавт.…”

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“…[26], S. Starkstein и соавт. [23], не выявили каких-либо изменений амплитуды. Одна-ко L. Wang и соавт.…”

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Event-related potentials in Parkinson’s disease

Veryugina¹,

Glozman

Васенина³

2015

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Хотя когнитивные нарушения не являются начальным симптомом болезни Паркинсона (БП), по мере прогрессирования заболевания они постепенно развиваются и могут достичь степени деменции. Метод когнитивных вызванных потенциалов с оценкой волны Р300 чувствителен к когнитивным нарушениям, в связи с чем его применяют для оценки когнитивных функций при БП. Несмотря на то что во многих исследованиях выявлены корреляционные связи латентности и амплитуды Р300 с когнитивными функциями при БП, существует значительное число и противоположных результатов. В статье представлен их обзор. Авторы считают, что рассматриваемый метод должен применяться только в сочетании с клиническим и нейропсихологическим исследованиями и требует дальнейшего изучения. Ключевые слова: когнитивные вызванные потенциалы, болезнь Паркинсона, Р300.Cognitive deterioration is not an initial symptom of Parkinson's disease but occurs over the course of the disease with the incidence of dementia. The P300 component of event-related potentials appears to be sensitive to cognitive impairment, and has been used to examine cognitive functions in Parkinson's disease. Although many studies have shown that P300 latency and amplitude are correlated with cognitive functions, there is a sufficient amount of controversial results. The authors have reviewed the results and suggested that the method should be used only in the combination with clinical and neuropsychological examinations. Further studies are needed.

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Evoked potentials, reaction time and cognitive performance in on and off phases of Parkinson's disease.

Cited by 74 publications

References 7 publications

Event-related potentials and cognition in Parkinson’s disease: An integrative review

Event-related potentials and cognition in Parkinson’s disease: An integrative review

Event-Related Potentials in Parkinson’s Disease: A Review

Event-related potentials in Parkinson’s disease

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