Evolution and Impact of Nucleic Acid Amplification Test (NAAT) for Diagnosis of Coronavirus Disease

Khan, Sumbul Fatma; Rathod, Priyanka; Gupta, Vivek K.; Khedekar, Pramod B.; Chikhale, Rupesh V.

doi:10.1021/acs.analchem.3c05225

Anal. Chem.

2024

DOI: 10.1021/acs.analchem.3c05225

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Evolution and Impact of Nucleic Acid Amplification Test (NAAT) for Diagnosis of Coronavirus Disease

Sumbul Fatma Khan,

Priyanka Rathod,

Vivek K. Gupta

et al.

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Cited by 4 publications

References 103 publications

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State-of-the-art signal amplification strategies for nucleic acid and non-nucleic acid biosensors

Gul,

Raheem,

Reyad-ul-Ferdous

et al. 2025

Sensors and Actuators Reports

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State-of-the-art signal amplification strategies for nucleic acid and non-nucleic acid biosensors

Gul,

Raheem,

Reyad-ul-Ferdous

et al. 2025

Sensors and Actuators Reports

View full text Add to dashboard Cite

CRISPR diagnostics for WHO high-priority sexually transmitted infections

Gul,

Raheem,

Reyad-ul-Ferdous

et al. 2025

TrAC Trends in Analytical Chemistry

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On-Site Visualization Assay for Tumor-Associated miRNAs: Using Ru@TiO₂ as a Peroxidase-like Nanozyme

Zhang,

He,

Bai

et al. 2024

Anal. Chem.

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Accurate diagnosis of highly aggressive and deadly tumors is essential for effective treatment and improved patient outcomes, and microRNAs (miRNAs) have emerged as crucial biomarkers for their roles in tumor initiation, progression, and metastasis. Herein, we present an on-site visualization colorimetric assay for tumor-associated miRNAs using ruthenium nanoparticle decorated titanium dioxide nanoribbon (Ru@TiO 2 ) as a peroxidase-like (POD) nanozyme. Remarkably, the Ru@TiO 2 nanozyme can catalyze the oxidation of chromogenic substrates through its POD-like activity, which is effectively inhibited by pyrophosphate generated during the rolling circle amplification process, thereby enabling miRNA detection through a visible colorimetric readout. This approach provides a highly sensitive and specificity assay for miRNAs in diluted human serum with a detection limit of 100 pM. It shows great potential for clinical diagnostics and biological research, offering a promising tool for early cancer diagnosis and molecular diagnostics.

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Evolution and Impact of Nucleic Acid Amplification Test (NAAT) for Diagnosis of Coronavirus Disease

Cited by 4 publications

References 103 publications

State-of-the-art signal amplification strategies for nucleic acid and non-nucleic acid biosensors

State-of-the-art signal amplification strategies for nucleic acid and non-nucleic acid biosensors

CRISPR diagnostics for WHO high-priority sexually transmitted infections

On-Site Visualization Assay for Tumor-Associated miRNAs: Using Ru@TiO₂ as a Peroxidase-like Nanozyme

Contact Info

Product

Resources

About

Evolution and Impact of Nucleic Acid Amplification Test (NAAT) for Diagnosis of Coronavirus Disease

Cited by 4 publications

References 103 publications

State-of-the-art signal amplification strategies for nucleic acid and non-nucleic acid biosensors

State-of-the-art signal amplification strategies for nucleic acid and non-nucleic acid biosensors

CRISPR diagnostics for WHO high-priority sexually transmitted infections

On-Site Visualization Assay for Tumor-Associated miRNAs: Using Ru@TiO2 as a Peroxidase-like Nanozyme

Contact Info

Product

Resources

About

On-Site Visualization Assay for Tumor-Associated miRNAs: Using Ru@TiO₂ as a Peroxidase-like Nanozyme