Evolution and significance of circulating procalcitonin levels compared with IL-6, TNFα and endotoxin levels early after thermal injury

Carsin, H.; Assicol, Marcel; Féger, Frédéric; Roy, Oliviér; Pennacino, I; Bever, H. Le; Ainaud, P.; Bohuon, C

doi:10.1016/s0305-4179(96)00124-6

Cited by 150 publications

(84 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Serum procalcitonin (PCT)-a marker of septicemia and infection severity [2]-has also been proposed as an indicator of systemic inflammatory response in noninfectious situations [3,4]. As no data exist thus far on PCT in stroke, this study aimed to evaluate serum PCT changes in the acute stroke setting, and to correlate them with clinical and laboratory parameters and patient's outcome.…”

Section: To the Editormentioning

confidence: 99%

“…At presentation and at day 7, the Glascow Coma Scale (GCS), the National Institute of Health Stroke Scale (NIHSS), and the Acute Physiology And Chronic Health Evaluation (APACHE) II score (only on admission) were performed, and full blood count, fibrinogen, C-reactive protein (CRP), glucose, urea, creatinine, electrolytes, albumin, total protein, lipids, creatine kinase (CK), lactate dehydrogenase (LDH) and PCT were measured. PCT was also measured on days 2, 3 and 4, since serum PCT levels reach their peak between 48 and 72 h [3,4]. An axillary temperature measurement was taken every 3 h in all patients.…”

Section: To the Editormentioning

confidence: 99%

See 1 more Smart Citation

Serial serum procalcitonin changes in the prognosis of acute stroke

Miyakis

Georgakopoulos

Kiagia

et al. 2004

Clinica Chimica Acta

View full text Add to dashboard Cite

Section: To the Editormentioning

confidence: 99%

Section: To the Editormentioning

confidence: 99%

Serial serum procalcitonin changes in the prognosis of acute stroke

Miyakis

Georgakopoulos

Kiagia

et al. 2004

Clinica Chimica Acta

View full text Add to dashboard Cite

“…67 Of note, TNFA (-308) polymor-phism is also associated with other infectious diseases, including leprosy and TB. 68,69 Also, TNFA is physically close to the LTA gene, which has also been described in association with leprosy; both genes are located at chromosomal region 6p21 harboring the MHC/HLA complex, reinforcing the importance of this genome segment in multiple infectious diseases. 13 INF-γ, the immune modulator coded by the INFG gene, is a cytokine critical to innate and adaptive immunity against intracellular bacterial infections.…”

Section: Host Genetics and Susceptibility To Leishmaniasismentioning

confidence: 86%

Genetic risk factors for human susceptibility to infections of relevance in dermatology

Sardinha

Tarlé

Fava

et al. 2011

An. Bras. Dermatol.

View full text Add to dashboard Cite

BACKGROUND: In the pre-microbiological era, it was widely accepted that diseases, today known to be infectious, were hereditary. With the discovery of microorganisms and their role in the pathogenesis of several diseases, it was suggested that exposure to the pathogen was enough to explain infection. Nowadays, it is clear that infection is the result of a complex interplay between pathogen and host, therefore dependant on the genetic make-up of the two organisms. Dermatology offers several examples of infectious diseases in different stages of understanding of their molecular basis. In this review, we summarize the main advances towards dissecting the genetic component controlling human susceptibility to infectious diseases of interest in dermatology. Widely investigated diseases such as leprosy and leishmaniasis are discussed from the genetic perspective of both host and pathogen. Others, such as rare mycobacterioses, fungal infections and syphilis, are presented as good opportunities for research in the field of genetics of infection. Keywords: Dermatology; Infection; Polymorphism, genetic Resumo: INTRODUÇÃO: Durante a era pré-microbiológica, era comum a visão de que doenças, hoje sabidamente infecciosas, eram hereditárias. Com a descoberta dos microorganismos e seu papel na patogênese de diversas patologias, chegou-se a propor que a exposição ao patógeno era condição suficiente para explicar infecção. Hoje, está claro que infecção é o resultado de uma complexa interação entre patógeno e hospedeiro, dependendo portanto, em última análise, do make-up genético de ambos os organismos. A dermatologia oferece diversos exemplos de doenças infecciosas em diferentes graus de entendimento de suas bases moleculares. Nesta revisão, resumimos os principais avanços na direção da dissecção do componente genético controlando suscetibilidade do ser humano a doenças infecciosas de importância na dermatologia. Doenças amplamente estudadas, como a hanseníase e a leishmaniose, são discutidas sob o ponto de vista da genética tanto do hospedeiro quanto do patógeno. Outras, como micobacterioses raras, micoses e sífilis, são apresentadas como boas oportunidades para pesquisa na área de genética de infecção.

show abstract

“…In contrast, Carsin ef ai. reported that per levels, which were elevated in all patients without any proven infection, correlated well with the sevel;ty of skin burn injury and were not associated with smoke inhalation injur~: peT and interleukin-6 peaks in the first 24 h after injun' were good prognostic factors of mortality (62).…”

Section: Procalcitonin Plasma Concentrations After Surgery and Traumamentioning

confidence: 85%

Procalcitonin and Neopterin in Infectious Diseases

Wiedermann¹,

Innerhofer²,

Margreiter³

et al. 1999

Pteridines

View full text Add to dashboard Cite

SummaryProcalcitonin, a new inflammation parameter, has been shown to be markedly increased in patients with severe bacterial and parasitic infections, septic shock, and multiple organ failure. In contrast, in severe viral infections or inflammatory reactions of non-infectious origin (e.g. toxic acute respiratory distress syndrome or toxic pancreatitis) as well as in autoimmune disorders, there is little or moderate increase of procalcitonin serum levels. Therefore procalcitonin may be used for diHerential diagnosis of bacterial versus non-bacterial inflammation. Furthermore, procaicitonin correlates with the severity of infection and sepsis and it is considered to be a valid parameter t()r monitoring both the severity and the course of sepsis and multiple organ failure as well as the success of surgical ~lI1d intensin.' therapy in critically ill patients. Neopterin production is closely associated with activation of the celluLll' immune sYstem. High neopterin levels are found in several inflamlnatory diseases and certain malignancies. ~eopterin me~lsurements are usehll for monitoring allograft recipients to detect immunological c0111plicltions. In autoimmune diseases, neopterin concentrations reflect the extent and activity of disease . In intl-crious dise~lscs, ncopterin helps in the differential diagnosis of acute viral and bacterial infections and provides prognostic intc)rmarion in human immunodeficiency virus disease and in patients with rnultiple trauma and sepsis. In this article the clinical application of procalcitonin and neopterin in infectious diseases is reyiewed, and special emphasis is given to clinical simarions in " 'hich the combined determination of both par~1l11ctcrs, neoprerin and procalcitonin, is able to suppon ditkrential diagnosis.

show abstract

Evolution and significance of circulating procalcitonin levels compared with IL-6, TNFα and endotoxin levels early after thermal injury

Cited by 150 publications

References 14 publications

Serial serum procalcitonin changes in the prognosis of acute stroke

Serial serum procalcitonin changes in the prognosis of acute stroke

Genetic risk factors for human susceptibility to infections of relevance in dermatology

Procalcitonin and Neopterin in Infectious Diseases

Contact Info

Product

Resources

About