Evolution of Electrocardiographic Abnormalities in Association with Neuromuscular Disorders and Survival in Left Ventricular Hypertrabeculation/Noncompaction

Abstract

LVHT-patients develop frequently new ECG abnormalities of prognostic relevance.

Echocardiographic and clinical markers of left ventricular ejection fraction and moderate or greater systolic dysfunction in left ventricular noncompaction cardiomyopathy

“…Importantly, this group of patients also experienced conduction system disease in the form of QRS prolongation. Previous studies have shown that a QRS duration >120 ms, as well as an absolute increase in QRS duration, are independent predictors of mortality in patients with LVNC . Thus, it can be hypothesized that GLS worsening and QRS prolongation may be a manifestation of increased LV fibrosis, which has been associated with progressive LV systolic dysfunction in LVNC .…”

“…Previous studies have shown that a QRS duration >120 ms, as well as an absolute increase in QRS duration, are independent predictors of mortality in patients with LVNC. 26 Thus, it can be hypothesized that GLS worsening and QRS prolongation may be a manifestation of increased LV fibrosis, which has been associated with progressive LV systolic dysfunction in LVNC. 27 Placed in this context, GLS and QRS duration may help detect individuals with LVNC and preserved or mildly reduced LVEF who are at risk of onset or worsening LV systolic dysfunction.…”

Importância do eletrocardiograma de repouso, de alta resolução e do Holter de 24 horas em pacientes com miocárdio não compacto: relação com os achados do ecocardiograma e ressonância magnética cardíaca

“…fibrilação atrial, presente em mais de 26% dos casos, tendo associação com pior prognóstico55 . Também são observados bloqueio de ramo direito, bloqueio de ramo esquerdo, bloqueio divisional anterior esquerdo e alteração inespecífica de repolarização56 .…”