Evolution of erectile dysfunction in individuals infected with human T-lymphotropic virus 1: a prospective cohort study

Abstract

Background Virtually all patients with human T-lymphotropic virus 1 (HTLV-1)–associated myelopathy/tropical spastic paraparesis (HAM/TSP) have some degree of erectile dysfunction (ED), but ED is also found in a large percentage of HTLV-1 carriers. Aim To evaluate the evolution of ED in individuals infected with HTLV-1 who were followed for up to 15 years. Methods This prospective cohort study included men infected with HTLV-1 who had ED, were aged 18 to 70 years, and were followed from January 2004 to December 2019. We used the International Index of Erectile Function–5 (IIEF-5), the Expanded Disability Status Scale and Osame Motor Disability Scale, and the Overactive Bladder Symptom Score (OABSS) to define and stratify ED, neurologic disability, and bladder dysfunction, respectively. Outcomes Time to development of severe ED was the main outcome. Results We studied 90 men with ED (mean ± SD age, 52.8 ± 9.78 years). At baseline, 42 were carriers, 16 had probable HAM/TSP, and 32 had definite HAM/TSP. IIEF-5 was highest among carriers and lowest in patients with definite HAM/TSP, whereas OABSS was lowest in carriers and highest in patients with definite HAM/TSP. Median (IQR) follow-up was 8.50 years (3.00-12.00). IIEF-5 fell significantly from baseline to last follow-up among carriers and patients with probable and definite HAM/TSP. There was an inverse correlation between the IIEF-5 and the OABSS at last follow-up (r = −0.62, P < .001). In survival analysis, the time to development of severe ED was significantly shorter in patients with definite HAM/TSP when compared with carriers (P = .001) and those with probable HAM/TSP (P = .014). The presence of definite HAM/TSP at baseline was independently associated with the development of severe ED, after adjustment for baseline age and proviral load (hazard ratio, 6.74; P = .008). Clinical Implications Formal assessment of erectile function should be part of the routine clinical assessment of individuals infected with HTLV-1; worsening erectile function should alert clinicians to the possibility of neurologic deterioration. Strengths and Limitations This is the first prospective cohort study to describe the course of ED in men infected with HTLV-1. The small sample size and absence of seronegative controls are limitations. Conclusion ED is a slowly progressive clinical manifestation of HTLV-1 infection, and the degree of neurologic compromise at baseline is the main predictor of time to progression to severe ED.

Заболевания, Ассоциированные С Т-Лимфотропным Вирусом Типа 1 Человека (HTLV-1)

“…HAM/TSP -редкое воспалительное заболевание, вызывающее прогрессирующие неврологические расстройства, такие как спастический парапарез, нейрогенный мочевой пузырь и сенсорные нарушения нижних конечностей [57]. Практически все пациенты с HAM/TSP страдают эректильной дисфункцией [58]. Как правило, HAM/TSP медленно прогрессирует, но его симптоматика может варьировать от ограниченного нарушения двигательной функции через десятилетия (очень медленное прогрессирование) до полной потери двигательной функции через несколько лет от начала заболевания (быстрое прогрессирование) [59].…”