Over the past decade, relentless efforts have brought lightweight high-temperature γ-TiAl-based intermetallic alloys into real commercialisation. The materials have found their place in General Electric’s (GE) high bypass turbofan aircraft engines for the Boeing 787 as well as in the PW1100GTF engines for low-pressure turbine (LPT) blades. In service, the alloys are required to withstand hostile environments dominated by cyclic stresses or strains. Therefore, to enhance the fatigue resistance of the alloys, a clear understanding of the alloys’ response to fatigue loading is pivotal. In the present review, a detailed discussion about the low-cycle fatigue (LCF) behaviour of γ-TiAl-based alloys in terms of crack initiation, propagation and fracture mechanisms, and the influence of temperature and environment on cyclic deformation mechanisms and the resulting fatigue life has been presented. Furthermore, a comprehensive discussion about modelling and prediction of the fatigue property of these alloys with regard to the initiation and propagation lives as well as the total fatigue life has been provided. Moreover, effective methods of optimising the microstructures of γ-TiAl-based alloys to ensure improved LCF behaviour have been elucidated.