Evolution of Morphology and Microstructure in Electrodeposited Nanocrystalline Al–Mg Alloy Dendrites

Tatiparti, Sankara Sarma V.; Ebrahimi, Fereshteh

doi:10.3390/met1010003

Cited by 8 publications

(6 citation statements)

References 24 publications

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“…27,49,68 As for delivery tools of gene medicine, the nanoparticle-based delivery system has been well studied and developed. [52][53][54] Several nanoplatforms have been reported to deliver miRNA or anti-miRNA as therapeutic agents. 27,[55][56][57][58] However, the clinical translation remains challenging due to various barricades, including undefined size and shape, particle aggregation or dissociation, nonspecific targeting, poor tumor accumulation, and undesirable immunogenicity.…”

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confidence: 99%

RNA Micelles for the Systemic Delivery of Anti-miRNA for Cancer Targeting and Inhibition without Ligand

Yin

Wang

et al. 2018

ACS Nano

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Displaying the advantage of nanoparticles in cancer targeting and drug delivery, micelles have shown great potential in cancer therapy. The mechanism for micelle targeting to cancer without the need for ligands is due to the size advantage of micelles within the lower end of the nanometer scale that is the optimal size for favoring the enhanced permeability and retention (EPR) effect while escaping trapping by macrophages. MicroRNAs are ubiquitous and play critical roles in regulating gene expression, cell growth, and cancer development. However, their in vivo delivery in medical applications is still challenging. Here, we report the targeted delivery of anti-miRNA to cancers via RNA micelles. The phi29 packaging RNA three-way junction (pRNA-3WJ) was used as a scaffold to construct micelles. An oligo with 8nt locked nucleic acid (LNA) complementary to the seed region of microRNA21(miR21) was included in the micelles as an interference molecule for cancer inhibition. These RNA micelles carrying anti-miR21 exhibited strong binding and internalization to cancer cells, inhibited the function of oncogenic miR21, enhanced the expression of the pro-apoptotic factor, and induced cell apoptosis. Animal trials revealed effective tumor targeting and inhibition in xenograft models. The inclusion of folate as a targeting ligand in the micelles did not show significant improvement of the therapeutic efficacy in vivo, suggesting that micelles can carry therapeutics to a target tumor and inhibit its growth without ligands.

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confidence: 99%

RNA Micelles for the Systemic Delivery of Anti-miRNA for Cancer Targeting and Inhibition without Ligand

Yin

Wang

et al. 2018

ACS Nano

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“…We electrodeposited nanocrystalline supersaturated metastable Al−Mg dendrites for H2−storage [12]. By thorough analyses we understood the Al-Mg electrodeposition scheme [13]; internal [14], external morphological [12], microstructural [15], compositional [16,17], textural [18], phase [19] features; and the dendritic growth mechanisms [20,21]. [12].…”

Section:   mentioning

confidence: 99%

Nanostructure stabilization in electrodeposited Al–Mg dendrites

Tatiparti

Ebrahimi

2017

Journal of Alloys and Compounds

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Electrodeposited Al−Mg dendrites with globular morphology exhibited core−shell (coarse−fine) type microstructure with grain sizes ~100 and ~16 nm, respectively. The grain boundary and grain compositions of core are ~10 and ~6 at.% Mg, respectively. Those of shell are ~36 and ~20 at.% Mg, respectively. The excess Mg ratio at boundaries of shell and core (Mg,fine/Mg,coarse) is 1.17:1. This relative grain boundaries segregation of Mg decreases the grain boundary energy from coarse to fine region and can result in nanostructure stabilization of fine shell at ~16 nm.

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“…2c) with a sharp compositional change across their interface. 26,29,35 With the increase in the pre-electrodeposition time (>80 min) the volume fraction of the rough globules possessing hcp Mg(+Al) phase increases (Figs. 2d and Deposit # 4 in Fig.…”

Section: Overall Compositions Of Deposits and Electrolytes-figurementioning

confidence: 99%

“…34 In yet another study, the morphological evolution from featherlike to globular dendrites was attributed to changing local current densities. 35 In the present study we investigate on the classification of the type of Al-Mg electrodeposition under present experimental conditions by compositional analysis of the deposits and electrolytes. Our analysis shows that under present experimental conditions Al-Mg electrodeposition can be classified as anomalous type.…”

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Anomalous Al–Mg Electrodeposition Using an Organometallic-Based Electrolyte

Tatiparti¹,

Ebrahimi²

2016

J. Electrochem. Soc.

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The Al–Mg electrodeposition is investigated using the organometallic–based electrolyte: Na[AlEt4]+2Na[Et3Al–H–AlEt3]+2.5AlEt3+6toluene (Et =-C2H5), employing Mg anode. With an increase of Mg in the deposit the predominant morphology and its composition changes from ground (90–95 atom% Al) to smooth globules (75–80 atom% Al) to rough globules (15–45 atom% Al). The ground and smooth globules possessed face centered cubic (fcc) Al(+Mg) phase and the rough globules possess hexagonal close packed (hcp) Mg(+Al) phase. The overall composition (atom% Al-the more noble metal) of the deposits is less than that of the electrolyte, and increases steeply with a slight change in the latter. This indicates the absence of preferred deposition of the more noble metal suggesting the anomalous electrodeposition of Al-Mg. A critical ratio of Al/Mg exists in the electrolyte beyond which the anomalousness is enhanced. This critical ratio is identified by the onset of hcp Mg(+Al) phase formation in the deposits. A lack of trend in the overall deposit composition with electrolyte agitation affirms the anomalous electrodeposition of Al–Mg system under present experimental conditions.

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Evolution of Morphology and Microstructure in Electrodeposited Nanocrystalline Al–Mg Alloy Dendrites

Cited by 8 publications

References 24 publications

RNA Micelles for the Systemic Delivery of Anti-miRNA for Cancer Targeting and Inhibition without Ligand

RNA Micelles for the Systemic Delivery of Anti-miRNA for Cancer Targeting and Inhibition without Ligand

Nanostructure stabilization in electrodeposited Al–Mg dendrites

Anomalous Al–Mg Electrodeposition Using an Organometallic-Based Electrolyte

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