Evolution of type 2 diabetes mellitus treatment approaches

Bloomgarden, Zachary T.

doi:10.1111/1753-0407.12854

Cited by 3 publications

(2 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Diabetes mellitus (DM), a common human health problem around the globe, is a metabolic disorder and it is characterized by high levels of blood sugar (hyperglycemia), causing dysfunction in insulin secretion and/or sensitivity [ 276 , 277 , 278 , 279 , 280 ]. Insulin is a hormone synthesized in the β-cell of the pancreas and its action is also regulated by the pancreatic β-cell [ 280 ].…”

Section: Selenoproteins and Human Healthmentioning

confidence: 99%

Selenium—More than Just a Fortuitous Sulfur Substitute in Redox Biology

Maia,

Maiti,

Moura

et al. 2023

Molecules

View full text Add to dashboard Cite

Living organisms use selenium mainly in the form of selenocysteine in the active site of oxidoreductases. Here, selenium’s unique chemistry is believed to modulate the reaction mechanism and enhance the catalytic efficiency of specific enzymes in ways not achievable with a sulfur-containing cysteine. However, despite the fact that selenium/sulfur have different physicochemical properties, several selenoproteins have fully functional cysteine-containing homologues and some organisms do not use selenocysteine at all. In this review, selected selenocysteine-containing proteins will be discussed to showcase both situations: (i) selenium as an obligatory element for the protein’s physiological function, and (ii) selenium presenting no clear advantage over sulfur (functional proteins with either selenium or sulfur). Selenium’s physiological roles in antioxidant defence (to maintain cellular redox status/hinder oxidative stress), hormone metabolism, DNA synthesis, and repair (maintain genetic stability) will be also highlighted, as well as selenium’s role in human health. Formate dehydrogenases, hydrogenases, glutathione peroxidases, thioredoxin reductases, and iodothyronine deiodinases will be herein featured.

show abstract

Section: Selenoproteins and Human Healthmentioning

confidence: 99%

Selenium—More than Just a Fortuitous Sulfur Substitute in Redox Biology

Maia,

Maiti,

Moura

et al. 2023

Molecules

View full text Add to dashboard Cite

show abstract

“…Although triglyceride levels were not increased, and liver histology in rodent and canine models did not show changes suggestive of NAFLD, future human studies should include liver imaging in a subset of treated people to address this potential adverse effect. Despite the tremendous advances seen with recent diabetes treatment approaches, the development of new approaches with novel mechanisms of action remains an important endeavor.…”

mentioning

confidence: 99%