Considering a moving two-level atom interacting with a single-mode thermal field through multi-photon process, in this paper we study the entropy exchange between the atom and the field by using quantum partial entropy and entanglement measured by using Concurrence, and investigate the effects of the initial atomic state, the atomic motion, the mean photon number and the transition photon number on entropy and entanglement. The results show that the entropy exchange and the entanglement exhibit the periodic evolution due to atomic motion, and entropy exchange occurs. The entanglement between the atom and the field is strengthened as the transition photon number increases. When the partial entropy exchange between atom and field is zero, the entanglement is also zero.