Evolution via somatic genetic variation in modular species

Reusch, Thorsten B. H.; Baums, Iliana B.; Werner, Benjamin

doi:10.1016/j.tree.2021.08.011

Cited by 36 publications

(36 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…S1). Hence, as Plomion et al (2018) and Reusch et al (2021) noted, some mutations were possibly overlooked in these studies. In a recent study, intra-meristem genetic mosaicisms were estimated by ultradeep resequencing (Yu et al, 2020).…”

Section: Discussionmentioning

confidence: 82%

“…With future technological progress, many mutations that have been neglected will be detectable, and a more accurate comparison with models may become possible. Single-cell DNA sequencing also has the potential to unveil mosaicism within the meristem (Reusch et al, 2021). In addition, the methodology may enable us to estimate the per cell somatic mutation rate independent of somatic genetic drift during elongation.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Modelling somatic mutation accumulation and expansion in a long-lived tree with hierarchical modular architecture

Tomimoto

Satake

2022

Preprint

View full text Add to dashboard Cite

In a long-lived organism with a modular architecture, such as trees, somatic mutations accumulate throughout the long lifespan and result in genetic mosaicism in each module within the same individual. In recent years, next-generation sequencing technology has provided a snapshot of such intra-organismal genetic variability. However, the dynamic processes underlying the accumulation and expansion of somatic mutations during the growth remain poorly understood. In this study, we constructed a model to describe these processes in a form that can be applied to a real sequenced tree. Given that the proliferation dynamics of meristematic cells vary across plant species, multiple possible processes for elongation and branching were comprehensively expressed in our model. Using published data from a poplar tree, we compared the prediction of the models with the observation and explained the cell lineage dynamics underlying somatic mutations accumulation that were not evident from the snapshot of the sequenced data. We showed that the somatic genetic drift during growth decreased the intra-meristem mosaicism, resulting in mutation distribution strictly reflecting tree topology. Our modelling framework can help interpret and replenish the new empirical findings of genetic mosaicism in long-lived trees.

show abstract

Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Modelling somatic mutation accumulation and expansion in a long-lived tree with hierarchical modular architecture

Tomimoto

Satake

2022

Preprint

View full text Add to dashboard Cite

show abstract

“…The difference between these cell populations is an obstacle to cancer therapy. The instability of tumor genome determines that tumor cells may undergo significant mutations after drug therapy, leading to rapid tumor progression or drug resistance [ 36 , 37 ]. Tumor cells developing heterogeneity during drug treatment are dynamic processes that follow a genetic law [ 8 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

Targeting IL8 as a sequential therapy strategy to overcome chemotherapy resistance in advanced gastric cancer

et al. 2022

View full text Add to dashboard Cite

Systemic chemotherapy with multiple drug regimens is the main therapy option for advanced gastric cancer (GC) patients. However, many patients develop relapse soon. Here, we evaluated the therapeutic potential of targeting interleukin-8 (IL8) to overcome resistance to chemotherapy in advanced GC. RNA sequencing revealed crucial molecular changes after chemotherapy resistance, in which the expression of IL8 was significantly activated with the increase in drug resistance. Subsequently, the clinical significance of IL8 expression was determined in GC population specimens. IL8-targeted by RNA interference or reparixin reversed chemotherapy resistance with limited toxicity in vivo and vitro experiments. Sequential treatment with first-line, second-line chemotherapy and reparixin inhibited GC growth, reduced toxicity and prolonged survival. Collectively, our study provides a therapeutic strategy that targeting IL8 as a sequential therapy after chemotherapy resistance in advanced GC.

show abstract

“…Gene loss due to natural LoF (loss-of-function) mutations, which are ubiquitous in the genomes of various organisms, has been somewhat overlooked. With the development of sequencing technology, many genomes have been sequenced in different species and used to study the variants contributing to variations in gene loss [ 164 ]. SoGV (somatic genetic variation) produces genetic variations late in ontogeny and is inherited in gametes, and sexual and asexual processes provide pathways for interdependent variant variation, affecting genetic load accumulation and molecular evolution in the integrated asexual/sexual life cycle [ 165 ].…”

Section: Conclusion and Future Prospectsmentioning

confidence: 99%

Root Breeding in the Post-Genomics Era: From Concept to Practice in Apple

Zhou

Zhang

Shu³

et al. 2022

Plants

View full text Add to dashboard Cite

The development of rootstocks with a high-quality dwarf-type root system is a popular research topic in the apple industry. However, the precise breeding of rootstocks is still challenging, mainly because the root system is buried deep underground, roots have a complex life cycle, and research on root architecture has progressed slowly. This paper describes ideas for the precise breeding and domestication of wild apple resources and the application of key genes. The primary goal of this research is to combine the existing rootstock resources with molecular breeding and summarize the methods of precision breeding. Here, we reviewed the existing rootstock germplasm, high-quality genome, and genetic resources available to explain how wild resources might be used in modern breeding. In particular, we proposed the ‘from genotype to phenotype’ theory and summarized the difficulties in future breeding processes. Lastly, the genetics governing root diversity and associated regulatory mechanisms were elaborated on to optimize the precise breeding of rootstocks.

show abstract

Evolution via somatic genetic variation in modular species

Cited by 36 publications

References 75 publications

Modelling somatic mutation accumulation and expansion in a long-lived tree with hierarchical modular architecture

Modelling somatic mutation accumulation and expansion in a long-lived tree with hierarchical modular architecture

Targeting IL8 as a sequential therapy strategy to overcome chemotherapy resistance in advanced gastric cancer

Root Breeding in the Post-Genomics Era: From Concept to Practice in Apple

Contact Info

Product

Resources

About