Evolving Personalized Therapy for Castration-Resistant Prostate Cancer

Liu, Hsin Ho; Tsai, Yuh Shyan; Lai, Chen Li; Tang, Chih Hsin; Lai, Chih Ho; Wu, Hsi Chin; Hsieh, Jer Tsong; Yang, Che Rei

doi:10.7603/s40681-014-0002-5

Cited by 19 publications

(12 citation statements)

References 71 publications

(75 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For patients with elevated risk factors or cancer recurrence, radiation therapy (RT) is one of the effective treatment options ( Dearnaley et al, 1999 ; Liu et al, 2014c ). However, a significant proportion of patients develop metastatic disease where RT is ineffective due to the development of radioresistance in PCa cells ( Hummerich et al, 2006 ; Liu et al, 2014b ).…”

Section: Introductionmentioning

confidence: 99%

Simvastatin Sensitizes Radioresistant Prostate Cancer Cells by Compromising DNA Double-Strand Break Repair

et al. 2018

Self Cite

View full text Add to dashboard Cite

Prostate cancer (PCa) is one of the most prevalent male cancers in western world. Radiation therapy (RT) is commonly used to treat PCa patients. However, a certain proportion of patients develop radioresistant PCa cells, which results in metastatic disease. Statins, which inhibit 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase, are commonly used to treat hypercholesterolemia, exhibiting beneficial effects on cardiovascular diseases and on several types of cancers, including PCa. However, the mechanistic details and crosstalk between statins and RT in PCa cells remain unknown. In this study, radioresistant DOC-2/DAB2 interactive protein (DAB2IP)-deficient PCa cells were used to evaluate whether simvastatin could enhance the effect of ionizing radiation (IR). The crucial molecules that associated with simvastatin elevated radiosensitivity in PCa cells were explored. Our results demonstrated that a combination treatment with simvastatin and IR synergistically induced apoptosis of radioresistant PCa cells. In addition, simvastatin appeared to compromise DNA double-strand breaks repair by activating the expressions of histone 2A family member X (γ-H2AX) and phospho-checkpoint kinase 1 (p-CHK1), suggesting an underlying mechanism for this radiosensitization of PCa cells. These findings reveal that simvastatin may be a potent therapeutic agent for co-treatment with radiation to overcome radioresistance in PCa cells.

show abstract

Section: Introductionmentioning

confidence: 99%

Simvastatin Sensitizes Radioresistant Prostate Cancer Cells by Compromising DNA Double-Strand Break Repair

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…For patients with inoperable disease or high risk of cancer recurrence, radiation therapy is considered an optimal choice [2, 3]. However, some of these patients present with intrinsic radio-resistance or develop radio-resistance prior to or after radiotherapy [4].…”

Section: Introductionmentioning

confidence: 99%

Sensitization of radio-resistant prostate cancer cells with a unique cytolethal distending toxin

et al. 2014

Self Cite

View full text Add to dashboard Cite

Cytolethal distending toxin (CDT) produced by Campylobacter jejuni is a genotoxin that induces cell-cycle arrest and apoptosis in mammalian cells. Recent studies have demonstrated that prostate cancer (PCa) cells can acquire radio-resistance when DOC-2/DAB2 interactive protein (DAB2IP) is downregulated. In this study, we showed that CDT could induce cell death in DAB2IP-deficient PCa cells. A combination of CDT and radiotherapy significantly elicited cell death in DAB2IP-deficient PCa cells by inhibiting the repair of ionizing radiation (IR)-induced DNA double-strand break (DSB) during G2/M arrest, which is triggered by ataxia telangiectasia mutated (ATM)-dependent DNA damage checkpoint responses. We also found that CDT administration significantly increased the efficacy of radiotherapy in a xenograft mouse model. These results indicate that CDT can be a potent therapeutic agent for radio-resistant PCa.

show abstract

“…The main biologically active form of endogenous androgens is testosterone through the action of a P450 family member (commonly known as 5α-reductase). Androgen is an important factor in body composition at age-associated changes in men —for instance, in an increase in fat mass and a decrease in lean body mass [ 61 ]. Epidemiological studies have shown a bidirectional relationship between low testosterone levels and obesity in men [ 62 ].…”

Section: Candidate Genes/pathwaysmentioning

confidence: 99%

Current concepts regarding developmental mechanisms in diabetic retinopathy in Taiwan

Chen

Hsu

Lin

et al. 2016

BioMed

View full text Add to dashboard Cite

Diabetic retinopathy (DR) is one of the most feared complications of diabetes and is a leading cause of acquired blindness in working adults. The prevalence of undiagnosed diabetes in Taiwan is about 4%, and the annual incidence of T2D (Type 2 Diabetes) in Taiwan is 1.8% following the 1985 WHO criteria. Multiple mechanisms have been shown in T2DR with some signaling pathways, including the polyol pathway, PKC pathway, AGEs pathway, and MAPK pathway. However, the cause of vision loss in diabetic retinopathy is complex and remains incompletely understood. Herein, we try to fully understand the new concepts regarding hyperglycemia-induced biochemical pathways contributing to DR pathophysiology. Our work may be able to provide new strategies for the prevention and treatment of diabetic vascular complications.

show abstract

Evolving Personalized Therapy for Castration-Resistant Prostate Cancer

Cited by 19 publications

References 71 publications

Simvastatin Sensitizes Radioresistant Prostate Cancer Cells by Compromising DNA Double-Strand Break Repair

Simvastatin Sensitizes Radioresistant Prostate Cancer Cells by Compromising DNA Double-Strand Break Repair

Sensitization of radio-resistant prostate cancer cells with a unique cytolethal distending toxin

Current concepts regarding developmental mechanisms in diabetic retinopathy in Taiwan

Contact Info

Product

Resources

About