Evolving swaps in transplantation: global exchange, vouchers, liver, and trans-organ paired exchange

Lo, Alexis; Sonnenberg, Elizabeth M.; Abt, Peter L.

doi:10.1097/mot.0000000000000621

Cited by 7 publications

(2 citation statements)

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“…Since there is an imbalance between organ transplantation demand and availability in the United States, Global Paired Exchange could be an excellent option to improve the immunologic diversity of donors by including donor and recipient pairs from countries with low healthcare resources for end-stage renal disease. Alongside all precautions, We believe that collaborative research between the United States and other countries can enhance this global paired exchanges program[ 17 - 19 ].…”

Section: Discussionmentioning

confidence: 99%

Unveiling transplantation research productivity of United States: A bibliometric analysis

Rawashdeh,

AlRyalat,

Abuassi

et al. 2023

World J Transplant

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BACKGROUND The United States has witnessed significant advancements in the field of organ transplantation over the course of the last five decades, as demonstrated by a notable increase in the quantity of academic research. The presence of a highly dynamic research environment necessitates continuous evaluations to maintain the integrity and progress of the field. AIM To evaluate the total output and thematic emphasis of transplant research conducted in the United States. METHODS On January 10, 2023, we conducted a bibliometric search of United States research output in transplantation journals from the Web of Science database's Science Citation Index Expanded. We excluded editorials, meeting abstracts, and other non-article types. We analyzed annual trends, authors, institutions, articles, keywords, and countries collaborating with the United States, using VOSviewer 1.6.18 to create figures and tables. RESULTS The United States published 25956 papers (3078 reviews and 22878 articles) representing 37.7% of the world's scientific output. Canada emerged as the top collaborator with the United States, co-authoring 1263 articles. Leading institutions in United States transplantation research were the University of Pittsburgh (1749 articles), Mayo Clinic (1605 articles), Harvard Medical School (1549 articles), and Johns Hopkins University (1280 articles). The top three keywords with over 2000 occurrences were "recipients," "survival," and "outcomes," indicating a focus on graft and recipient outcome markers by United States researchers. CONCLUSION Our findings demonstrate the United States leadership in organ transplantation research, contributing significantly to the global scientific output in this field. However, opportunities exist for fostering expansive partnerships, particularly with developing countries. This study provides valuable insights into the transplantation research landscape in the United States, emphasizing the importance of ongoing evaluations to maintain and propel advancements in this critical medical discipline. The results may facilitate future collaborations, knowledge exchange, and the pursuit of innovative solutions in the realm of organ transplantation.

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Section: Discussionmentioning

confidence: 99%

Unveiling transplantation research productivity of United States: A bibliometric analysis

Rawashdeh,

AlRyalat,

Abuassi

et al. 2023

World J Transplant

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“…However, this patient–donor pair can often be biologically incompatible precluding the transplant. This incompatibility barrier can be overcome by an exchange of donors between patients (Delmonico et al., 2004; Lo et al., 2019; Roth et al., 2004; Saidman et al., 2006). Consequently, due to the large number of patients awaiting organ transplants, many developed countries such as the United States, United Kingdom, France, South Korea, and Japan implemented organ exchanges.…”

Section: Introductionmentioning

confidence: 99%

An optimization framework for analyzing dual‐donor organ exchange

Stauffer

Shetty

et al. 2023

Production and Operations Management

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We study an optimal matching problem in the context of dual-donor organ exchange, where a portion of two living donors' organs are transplanted to a single patient. This dual-donor transplant technique is becoming more widespread for lung and liver transplants. However, multiple medical compatibility criteria pose a serious challenge for matching a patient with two compatible donors. In the United States and many other countries, laws prohibit commercial (for-profit) deals for human organs, so donor exchanges are run by nonprofit organizations connecting donors with people in need of organs, with the goal of increasing transplant matches. We propose a simple chain mechanism in dual-donor organ exchange to increase the number of patient-dual-donor matches, which would maximize the number of patients receiving transplants. Based on this objective, we propose a general simple chain optimization framework for finding the maximum patient matching, taking into account multiple compatibility criteria (e.g., blood type and weight), and determine the complexity status of the problem. We provide theoretical results on the structures of simple chains, as well as a polynomial time algorithm to obtain the maximum patient matching simple chain with blood type compatibility. Through a numerical study for multiple compatibility criteria, we show that in many scenarios, a simple chain substantially increases the number of patients matched with dual donors for transplants, as opposed to exchange cycles. We also address the problem of maximizing the number of patients matched for dual-donor organ transplants via two-way and three-way exchange cycles, subject to donors' and recipients' medical compatibility criteria, along with a discussion of their computational complexity. Finally, we characterize the general configurations of large n-way exchange cycles and provide theoretical insights for their structural properties. Our findings provide general optimization models for dual-donor organ exchange operators to increase the number of patients matched for transplant, given multiple compatibility criteria. In addition, we show how exchange operators, using simple chains, can increase patient matches and reduce simultaneous surgical resource requirements over exchange cycles. K E Y W O R D Schain matching, dual-donor organ exchange, exchange cycles, mathematical programming, maximum independent set, nonprofit operations, NP-complete

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Kidney transplantation: the recipient

2024

Living Donor Organ Transplantation

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Evolving swaps in transplantation: global exchange, vouchers, liver, and trans-organ paired exchange

Cited by 7 publications

References 30 publications

Unveiling transplantation research productivity of United States: A bibliometric analysis

Unveiling transplantation research productivity of United States: A bibliometric analysis

An optimization framework for analyzing dual‐donor organ exchange

Kidney transplantation: the recipient

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