Evolving Trends and Future Prospects of Adr Monitoring and Reporting: A Literature Review

Amin, Aneela; Malik, Madeeha; Hussain, Azhar

doi:10.22159/ajpcr.2016.v9i5.12725

Cited by 7 publications

(1 citation statement)

References 42 publications

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“…In Pakistan, there was no active participation in pharmacovigilance as 80% of the hospitals had no proper ADR reporting system (Amin et al, 2016). The condition is similar in other gulf countries as mentioned above.…”

Section: Discussionmentioning

confidence: 87%

Evaluation of knowledge, attitude, and practice of medical and dental postgraduates toward reporting of adverse drug reactions in a teaching hospital, South India

Naga¹,

Naha²,

Rani³

et al. 2022

j app pharm sci

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This study aims to assess medical and dental postgraduates' knowledge, attitude, and practice (KAP) toward reporting adverse drug reactions (ADRs) and compare the KAP between the medical and dental postgraduates. A cross-sectional questionnaire-based study was conducted on 208 postgraduates (medical and dental postgraduates combined). The medical postgraduates belong to a tertiary care teaching hospital that is 2,000 bedded, serving a population of 1,177,361 in the southwest part of Karnataka, whereas the Dental postgraduates belong to teaching Dental hospitals from the same region as the above hospital received their accreditation by the Dental Council of India in 1970. Both the postgraduates had low KAP about the reporting system of ADRs and the ADR reporting system situated in this hospital. This study also found that the majority of the postgraduates had not attended the training sessions regarding the reporting of ADRs. This study concludes that the ADR reporting is crucial for all healthcare providers so that it initiates the exact actions by healthcare providers through which adverse events can be prevented, and will help in better drug management and thus the reputation of the hospital can be upgraded.

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Section: Discussionmentioning

confidence: 87%

Evaluation of knowledge, attitude, and practice of medical and dental postgraduates toward reporting of adverse drug reactions in a teaching hospital, South India

Naga¹,

Naha²,

Rani³

et al. 2022

j app pharm sci

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Liquid chromatographic and spectrofluorimetric assays of empagliflozin: Applied to degradation kinetic study and content uniformity testing

2018

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Stability-indicating high-performance liquid chromatography (HPLC) and spectrofluorimetric methods were developed for determination of empagliflozin (EGF). EGF was subjected to oxidation, wet heat, photo-degradation, acid hydrolysis and alkali hydrolysis. The alkaline degradation pathway was subjected to a kinetics study as the major product obtained after stress conditions. Arrhenius plots were constructed and the activation energies of the degradation process were calculated. HPLC was used for the kinetic study as it enabled simultaneous determination of EGF and the degradation product while the spectrofluorimetric assay was applied to content uniformity testing due to its higher sensitivity and lower limit of detection (LOD). Isocratic chromatographic elution was attained for HPLC on a Intersil® C column (150 mm × 4 mm, 5 μm), using a mobile phase of acetonitrile-potassium dihydrogen phosphate buffer pH 4, (50:50, v/v) at a flow rate of 1 ml/min with ultraviolet (UV) detection at 225 nm. The relative fluorescence intensity was recorded by spectrofluorimeter applying synchronous mode using ∆λ = 70 nm at 297.6 nm. Linearity ranges were found to be 5-50 μg/ml and 50-1000 ng/ml for HPLC and spectrofluorimetric methods, respectively.

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Determination of linagliptin and empagliflozin by UPLC and HPTLC techniques aided by lean six sigma approach

El-Desouky

Abdel-Raoof

Abdel‐Fattah

et al. 2021

Biomedical Chromatography

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Two chromatographic techniques were developed and validated for simultaneous determination of the newly co-formulated antidiabetic combination linagliptin and empagliflozin in their pure form and film-coated tables. The first technique was UPLC; the separation and resolution of both analytes were achieved using a Zorbax eclipse plus C 18 column applying an isocratic elution based on phosphate buffer pH 4-acetonitrile (65:35, v/v) as a running mobile phase at flow rate 1.5 ml/min and the effluent was monitored at 220 nm. Augmentation of Lean Six Sigma with UPLC and

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Evolving Trends and Future Prospects of Adr Monitoring and Reporting: A Literature Review

Cited by 7 publications

References 42 publications

Evaluation of knowledge, attitude, and practice of medical and dental postgraduates toward reporting of adverse drug reactions in a teaching hospital, South India

Evaluation of knowledge, attitude, and practice of medical and dental postgraduates toward reporting of adverse drug reactions in a teaching hospital, South India

Liquid chromatographic and spectrofluorimetric assays of empagliflozin: Applied to degradation kinetic study and content uniformity testing

Determination of linagliptin and empagliflozin by UPLC and HPTLC techniques aided by lean six sigma approach

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