Evolving use of PET viability imaging

Brito, Juliana Brenande de Oliveira; deKemp, Robert A.; Ruddy, Terrence D.

doi:10.1007/s12350-020-02460-2

Cited by 2 publications

(1 citation statement)

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“…Cardiac perfusion imaging is an effective supplement to metabolic studies in determining myocardial dysfunction [12]. The major difference is that it helps to understand the blood flow in coronary vasculature rather than depicting the activity of the muscle itself (compared to metabolic imaging).…”

Section: Discussionmentioning

confidence: 99%

Multiparametric Evaluation of Post-MI Small Animal Models Using Metabolic ([18F]FDG) and Perfusion-Based (SYN1) Heart Viability Tracers

Kolanowski

Wargocka-Matuszewska

Zimna

et al. 2021

IJMS

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Cardiovascular diseases (CVD), with myocardial infarction (MI) being one of the crucial components, wreak havoc in developed countries. Advanced imaging technologies are required to obtain quick and widely available diagnostic data. This paper describes a multimodal approach to in vivo perfusion imaging using the novel SYN1 tracer based on the fluorine-18 isotope. The NOD-SCID mice were injected intravenously with SYN1 or [18F] fluorodeoxyglucose ([18F]-FDG) radiotracers after induction of the MI. In all studies, the positron emission tomography–computed tomography (PET/CT) technique was used. To obtain hemodynamic data, mice were subjected to magnetic resonance imaging (MRI). Finally, the biodistribution of the SYN1 compound was performed using Wistar rat model. SYN1 showed normal accumulation in mouse and rat hearts, and MI hearts correctly indicated impaired cardiac segments when compared to [18F]-FDG uptake. In vivo PET/CT and MRI studies showed statistical convergence in terms of the size of the necrotic zone and cardiac function. This was further supported with RNAseq molecular analyses to correlate the candidate function genes’ expression, with Serpinb1c, Tnc and Nupr1, with Trem2 and Aldolase B functional correlations showing statistical significance in both SYN1 and [18F]-FDG. Our manuscript presents a new fluorine-18-based perfusion radiotracer for PET/CT imaging that may have importance in clinical applications. Future research should focus on confirmation of the data elucidated here to prepare SYN1 for first-in-human trials.

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Section: Discussionmentioning

confidence: 99%