ew pyridazinium-based ionic liquids: An eco-friendly ultrasound-assisted synthesis, characterization and biological activity

Messali, Mouslim; Almtiri, Mohammed; Bousskri, A.; Salghi, R.; Aouad, Mohamed Reda; Alshahateet, Solhe F.

doi:10.17159/0379-4350/2015/v68a30

Cited by 7 publications

(8 citation statements)

References 17 publications

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“…The same group also reported the ultrasound-assisted synthesis of new pyridazinium-based ILs, exhibiting good to moderate antibacterial activity [83]. Some of the tested ILs were also efficient in vitro against human breast adenocarcinoma, human colon carcinoma, and human hepatocellular carcinoma cell lines.…”

Section: Drug Synthesis In Ionic Liquidsmentioning

confidence: 96%

“…The same reduction of reaction time was reported under ultrasound (25 kHz, cleaning bath) in comparison to silent conditions, without more investigation of the ultrasonic effects. New pyridinium ILs with hydrozones tethering fluorinated counter anions were also prepared under ultrasound, showing novel inhibitors of fungal ergosterol biosynthesis [83]. The origin of this antifungal activity could be explained by the binding of the ILs to membrane ergosterol, leading to pore creation in fungal cell membranes, and then to the loss of intracellular content.…”

Section: Drug Synthesis In Ionic Liquidsmentioning

confidence: 99%

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Ultrasound for Drug Synthesis: A Green Approach

2020

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This last century, the development of new medicinal molecules represents a real breakthrough in terms of humans and animal life expectancy and quality of life. However, this success is tainted by negative environmental consequences. Indeed, the synthesis of drug candidates requires the use of many chemicals, solvents, and processes that are very hazardous, toxic, energy consuming, expensive, and generates a large amount of waste. Many large pharmaceutical companies have thus moved to using green chemistry practices for drug discovery, development, and manufacturing. One of them is the use of energy-efficient activation techniques, such as ultrasound. This review summarizes the latest most representative works published on the use of ultrasound for sustainable bioactive molecules synthesis.

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Section: Drug Synthesis In Ionic Liquidsmentioning

confidence: 96%

Section: Drug Synthesis In Ionic Liquidsmentioning

confidence: 99%

Ultrasound for Drug Synthesis: A Green Approach

2020

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“…Based on interesting results published recently, we focused on the preparation of a new family of RTILs (1-20) by using microwave irradiation and conventional procedure in order to test them for antitumor activities [37][38][39]. As shown in Scheme 1, 1propylimidazolium-based ionic liquids (1-5) have been synthesized through the reaction of 1-propylimidazole in toluene with a suitable alkyl bromide at 80°C for 18 h. The quaternization reaction was performed via the nucleophilic attack of the Sp 2 -N imidazole atom on the alkyl bromide in order to produce the desired imidazolium bromides (1-5).…”

Section: Synthesismentioning

confidence: 99%

Ecofriendly microwave-assisted preparation, characterization and antitumor activity of some propylimidazolium-based Ionic liquids derivatives

Alqurashy

2020

Journal of Taibah University for Science

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An ecofriendly and efficient preparation of a set of a new 1-propylimidazolium-based ionic liquids (1-20) has been manufactured by using both microwave irradiation and conventional procedure. Different spectral analysis (FT-IR, mass spectra, NMR and elemental analysis) were utilized to examine the structures of the newly prepared ILs. The in vitro antitumor activities of all ILs (1-20) were investigated, using viability assay, towards HEPG-2, MCF7 and CACO2 Cells. Among all tested ILs, the 3-(3-phenylpropyl)-1-propyl-1H-imidazol-3-ium tetrafluoroborate (13) showed better activity towards human hepatocellular carcinoma (HEPG-2) and colon carcinoma (CACO2), while the 3-(3-phenoxypropyl)-1-propyl-1H-imidazol-3-ium tetrafluoroborate (20) exhibited low IC 50 values against human breast adenocarcinoma (MCF7) compared to the standard drug (5fluorouracil (5-FU)). Generally, all ILs 1-20 derivatives showed moderate cytotoxic activity against all tested cell lines.

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“…Ionic liquids became attractive for use in numerous chemical and physical applications [42][43][44][45]. Furthermore, exciting biological activities of ILs against a wide range of microorganisms have been shown [46][47][48][49].…”

Section: Introductionmentioning

confidence: 99%

Ovicidal, pupicidal and bactericidal effects of aminopyridinium-based ionic liquids onCulex pipiensand certain human pathogenic bacteria

Ali

Ibrahim

Alahmadi

et al. 2020

Journal of Taibah University for Science

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Culex pipiens (Diptera: Culicidae) is one of the most prevalent mosquitoes particularly in the Al-Madinah Al-Munawwarah region, Kingdom of Saudi Arabia, transmitting numerous diseases such as arboviruses, avian malaria, elephantiasis, dirofilariasis, and encephalitis. Worldwide, Culex pipiens has developed resistance to numerous insecticides; therefore, considerable efforts have been done to introduce new mosquito control candidates. Due to their unique physical, biological, and eco-friendly properties, ionic liquids (ILs) have been recently considered as promising agents in controlling a variety of organisms. Six aminopyridinium-based ionic liquids (IL1-IL6) were assayed against eggs and pupae of C. pipiens. Percentages of non-hatched eggs, nonemerged pupae, the lethal concentrations (LC 50 and LC 90) of both C. pipiens eggs and pupae were recorded. after exposure, to different ILs. The effects of ILs against eggs and pupae were concentration and IL-dependant. The percentages of egg unhatchability were much higher than those of pupal mortality, as the percentage of egg unhatchability reached 99% after treatment with IL6 at 0.5 g/L, while the percentage of pupal mortality reached 40.8% after treatment with IL4 at 0.5 g/L. The LC 50 and LC 90 of ILs against pupae were much higher than those of ILs against eggs. Effects of ILs on Staphylococcus aureus (Bacillales: Staphylococcaceae) and Escherichia coli (Entrobacterales: Entrobacteriaceae) were also studied; some ILs showed a considerable effect on both bacteria species. This is the first study to show the ovicidal, pupicidal, and bactericidal effects of aminopyridinium-based ILs in controlling C. pipiens, S. aureus, and E. coli.

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ew pyridazinium-based ionic liquids: An eco-friendly ultrasound-assisted synthesis, characterization and biological activity

Abstract: An eco-friendly ultrasound-assisted procedure was developed for the preparation of a series of novel pyridazinium ionic liquids (ILs) 1-8.

Cited by 7 publications

References 17 publications

Ultrasound for Drug Synthesis: A Green Approach

Ultrasound for Drug Synthesis: A Green Approach

Ecofriendly microwave-assisted preparation, characterization and antitumor activity of some propylimidazolium-based Ionic liquids derivatives

Ovicidal, pupicidal and bactericidal effects of aminopyridinium-based ionic liquids onCulex pipiensand certain human pathogenic bacteria

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