Ewing's sarcoma presenting as a cervical intradural extramedullary tumor in a 42 year old: Report of a case

Johnson, Mahlon D.; Korones, David N.; L-N, Hazrati; Walter, Kevin A.; Hussain, Ali

doi:10.1016/j.inat.2019.100634

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…The final diagnosis requires immunohistochemical analysis and cytogenetic studies to identify (11;22) (q24; q12) translocation. EWS / ETS fusions as the presumed initiating oncogenic event required for proliferation and tumorigenesis [7][8][9][10][11].…”

Section: Discussionmentioning

confidence: 99%

Ewing’s Sarcoma of the Craniovertebral Junction - A Rare Cause of Reversible Quadriplegia. A Case Report with a 10-year Review of Literature

Ganapathy¹,

Jagadeesh²

2022

J Neurol Res Rev Rep

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Ewing’s sarcoma is a rare cause of spinal compressive, myelopathy. Its presence in the craniovertebral junction is even rarer. The presence of both with reversable myelopathy after surgery makes this a truly rare and fortunate instance of prompt neurosurgical decompression coupled with judicious use of adjuvant therapy to affect the best possible results for the patient. We present our experience in this case mentioned later along with a 10-year review of literature regarding the incidence, distribution and presentation of cervical spinal Ewing’s sarcoma to further demonstrate the rare nature of this remarkable case report.

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Section: Discussionmentioning

confidence: 99%

Ewing’s Sarcoma of the Craniovertebral Junction - A Rare Cause of Reversible Quadriplegia. A Case Report with a 10-year Review of Literature

Ganapathy¹,

Jagadeesh²

2022

J Neurol Res Rev Rep

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Primary Ewing’s Sarcoma affecting the Central Nervous System: A single-center experience and Narrative review

Kumarasamy,

Garg,

Singh

et al. 2024

Childs Nerv Syst

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The Role of Neuroaxis Irradiation in the Treatment of Intraspinal Ewing Sarcoma: A Review and Meta-Analysis

Troschel

Kröger

Siats

et al. 2022

Cancers

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The role of cranio-spinal irradiation (CSI) for primary extraosseous intraspinal Ewing sarcoma (EwS) remains unclear. Here, we evaluate clinical and survival outcomes in patients with primary intraspinal EwS treated with CSI as part of multimodal primary therapy regimens. We abstracted patient information, including details on treatment application, efficacy, and tolerance from the literature and our hospital database for a cohort of 24 primary intraspinal EwS patients treated with CSI. Median age was 25.5 years, median CSI dose was 36 Gy and mean boost dose was 12.8 Gy. Sixteen patients (66.7%) achieved complete radiological remission, another 5 patients demonstrated partial response and 1 patient showed no response to treatment. Compared to a cohort of patients treated with focal radiotherapy, CSI patients were more likely to have multifocal disease at time of diagnosis (p = 0.001) and intradural tumor location (p < 0.001). Despite over-representation of these unfavorable characteristics, there was no survival difference between groups (p = 0.58). While CSI shows promising results in the treatment of primary intraspinal EwS, treatment should be considered individually based on tumor and patient characteristics in the absence of prospective trials.

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Ewing's sarcoma presenting as a cervical intradural extramedullary tumor in a 42 year old: Report of a case

Cited by 3 publications

References 7 publications

Ewing’s Sarcoma of the Craniovertebral Junction - A Rare Cause of Reversible Quadriplegia. A Case Report with a 10-year Review of Literature

Ewing’s Sarcoma of the Craniovertebral Junction - A Rare Cause of Reversible Quadriplegia. A Case Report with a 10-year Review of Literature

Primary Ewing’s Sarcoma affecting the Central Nervous System: A single-center experience and Narrative review

The Role of Neuroaxis Irradiation in the Treatment of Intraspinal Ewing Sarcoma: A Review and Meta-Analysis

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