Ewing’s sarcoma/primitive neuroectodermal tumor (ES/PNET) of the penis

Kiliçaslan, İşın; Karayigit, Ebru; Bulut, F; Başaran, Mert; Dizdar, Yavuz; Aslay, I.; Uysal, Veli

doi:10.1007/s11255-007-9202-1

Cited by 10 publications

(6 citation statements)

References 10 publications

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“…Primary visceral ES/PNETs are very rarely seen aggressive tumors. We present this case as this is forth case of ES/PNETs with penile localization [1][2][3]. One case of EES metastasizing to penis was also reported [4].…”

Section: Introductionmentioning

confidence: 78%

Primary Ewing’s Sarcoma of Penis – A Rare Case Report

Sharma

Bakshi

Chheda

et al. 2011

Indian J Surg Oncol

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Section: Introductionmentioning

confidence: 78%

Primary Ewing’s Sarcoma of Penis – A Rare Case Report

Sharma

Bakshi

Chheda

et al. 2011

Indian J Surg Oncol

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“…EES may develop in soft tissues at virtually any anatomical location, but the main sites of involvement are the paravertebral region, the trunk, and the extremities (4, 6, 7, 10-13). However, primitive localization in the penis is extremely rare; only a few relevant cases have been reported in the previous literature (8,9,14,15). Due to the lack of specific clinical, radiological features and the rarity of the condition, it can easily be misdiagnosed by surgeons and radiologists.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Primary Ewing Sarcoma of the Penis With Multiple Metastases

et al. 2021

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Background: Ewing sarcoma is the second most common malignant bone tumor in children, but it rarely originates from extra-skeletal sites. The commonly involved sites of soft tissue include paravertebral spaces, lower extremities, the pelvis, head, and neck, while primary extra-skeletal Ewing sarcoma (EES) located in the genitals is extremely rare.Case Presentation: We report a young patient who presented to our hospital with a painful erection of the penis and limited motion of the left hip. Magnetic resonance imaging showed a hyperintense mass with invasion of adjacent tissue in the penis and a heterogeneously high signal lesion in the left proximal femur. 18F-fluorodeoxyglucose positron-emission tomography detected widespread metastatic lesions in the bilateral lung and multiple skeletons. An incisional biopsy of the penis was performed; the histopathological findings and EWS gene translocation identified by molecular analysis confirmed the diagnosis of Ewing sarcoma. Subsequently, the punch-biopsy specimen from the left femur showed undifferentiated small round cells, a finding consistent with the microscopic presence of Ewing sarcoma metastasis. However, after the first course of multiagent chemotherapy, the penile mass did not obtain stabilization but instead grew progressively with surface ulceration and multidrug resistant bacteria infection. Despite receiving antibiotics and maximal supportive therapy, the patient died from sepsis and lung metastasis complications in the intensive care unit 2 months later.Conclusion: This case indicates that although EES as a subtype of Ewing sarcoma is rare, it can occur virtually in any soft tissue site, even in the genitals. Therefore, clinicians need to distinguish this entity from other soft tissue sarcomas with rapid progression since early diagnosis and timely treatment of EES are pivotal for a favorable prognosis.

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“…To our best knowledge with extensive literature search, there are only 4 primary penile ES/PNET cases reported in the medical literature. 1-4…”

Section: Report Of a Casementioning

confidence: 99%

“…The first case of primary EES/PNET of the penis was reported in 1999 by Toh et al 1 Since then, only very few primary penile EES/PNET cases were listed in the literature. 2-4 Different characteristics of those cases are compared and summarized in Table 1.…”

Section: Commentsmentioning

confidence: 99%

Primary Ewing’s Sarcoma/Primitive Neuroectodermal Tumor (ES/PNET) of the Penis

Brimo

Zeizafoun

2012

Int J Surg Pathol

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Ewing's sarcomas/primitive neuroectodermal tumors (ES/PNETs) arise from a multipotent progenitor cell and are considered to be of neuroectodermal derivation. Most tumors commonly arise in the skeletal system, which are the classic ES/PNET and occasionally occur in the soft tissue of extraskeletal sites, which are named extraskeletal Ewing's sarcomas (EES/PNET). This study reports a case of a 28-year-old man with primary EES/PNET of the penis.

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Ewing’s sarcoma/primitive neuroectodermal tumor (ES/PNET) of the penis

Cited by 10 publications

References 10 publications

Primary Ewing’s Sarcoma of Penis – A Rare Case Report

Primary Ewing’s Sarcoma of Penis – A Rare Case Report

Case Report: Primary Ewing Sarcoma of the Penis With Multiple Metastases

Primary Ewing’s Sarcoma/Primitive Neuroectodermal Tumor (ES/PNET) of the Penis

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