Ex Vivo Effect of Ibogaine on the Transcriptional Level of Antioxidant Defense Related Genes in Honey Bee (Apis mellifera, L.) Midgut

Vukašinović, Elvira L.; Purać, Jelena; Kojić, Danijela; Čelić, Tatjana V.; Pihler, Ivan; Blagojević, Duško

doi:10.1590/1678-4324-2021200773

Cited by 2 publications

(1 citation statement)

References 21 publications

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“…It has been shown in several in vitro, ex vivo and in vivo experimental models that the biological activity of ibogaine, in addition to involving interaction with various types of receptors [ 2 , 16 , 17 ], is caused by rapid depletion of ATP, which is followed by an induction of enzymes related to energy metabolism, as well as increases in cellular reactive oxygen species (ROS) and the activity of antioxidant enzymes [ 18 , 19 , 20 , 21 , 22 , 23 , 24 ]. In our previous experiments in rats treated per os it was shown that ibogaine affected energy metabolism, antioxidant defense, and redox balance without life-threatening pathological effects on the liver and kidneys [ 10 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Ibogaine Induces Cardiotoxic Necrosis in Rats—The Role of Redox Processes

Vidonja Uzelac,

Tatalović,

Mijović

et al. 2024

IJMS

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Ibogaine is an organic indole alkaloid that is used in alternative medicine to combat addiction. Numerous cases of life-threatening complications and sudden deaths associated with ibogaine use have been reported, and it has been hypothesized that the adverse effects are related to ibogaine’s tendency to induce cardiac arrhythmias. Considering that the bioavailability of ibogaine and its primary metabolite noribogaine is two to three times higher in female rats than in male rats, we here investigated the effect of a single oral dose (1 or 20 mg/kg) of ibogaine on cardiac histopathology and oxidative/antioxidant balance. Our results show that ibogaine induced dose-dependent cardiotoxic necrosis 6 and 24 h after treatment and that this necrosis was not a consequence of inflammation. In addition, no consistent dose- and time-dependent changes in antioxidant defense or indicators of oxidative damage were observed. The results of this study may contribute to a better understanding of ibogaine-induced cardiotoxicity, which is one of the main side effects of ibogaine use in humans and is often fatal. Nevertheless, based on this experiment, it is not possible to draw a definitive conclusion regarding the role of redox processes or oxidative stress in the occurrence of cardiotoxic necrosis after ibogaine administration.

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Section: Introductionmentioning

confidence: 99%

Ibogaine Induces Cardiotoxic Necrosis in Rats—The Role of Redox Processes

Vidonja Uzelac,

Tatalović,

Mijović

et al. 2024

IJMS

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Ibogaine Has Sex-Specific Plasma Bioavailability, Histopathological and Redox/Antioxidant Effects in Rat Liver and Kidneys: A Study on Females

Tatalović

Uzelac

Mijović

et al. 2021

Life

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Ibogaine induces rapid changes in cellular energetics followed by the elevation of antioxidant activities. As shown earlier in male rats, ibogaine treatment with both 1 and 20 mg/kg b.w. per os led to significant glycogenolytic activity in the liver. In this work, female rats treated with the same doses of ibogaine per os displayed lower liver glycogenolytic activity relative to males, dilatation of the central vein and branches of the portal vein, and increased concentration of thiols 6 h after treatment. These changes were followed by increased catalase activity and lipid peroxidation, and decreased xanthine oxidase activity after 24 h. In kidneys, mild histopathological changes were found in all treated animals, accompanied by a decrease of glutathione reductase (after 6 and 24 h at both doses) and an increase of catalase (6 h) and xanthine oxidase activity (6 and 24 h). Ibogaine did not affect antioxidant enzymes activity in erythrocytes. Bioavailability of ibogaine was two to three times higher in females than males, with similar kinetic profiles. Compared to previous results in males, ibogaine showed sex specific effect at the level of antioxidant cellular system. Effects of ibogaine in rats are sex- and tissue-specific, and also dose- and time-dependent.

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Ex Vivo Effect of Ibogaine on the Transcriptional Level of Antioxidant Defense Related Genes in Honey Bee (Apis mellifera, L.) Midgut

Cited by 2 publications

References 21 publications

Ibogaine Induces Cardiotoxic Necrosis in Rats—The Role of Redox Processes

Ibogaine Induces Cardiotoxic Necrosis in Rats—The Role of Redox Processes

Ibogaine Has Sex-Specific Plasma Bioavailability, Histopathological and Redox/Antioxidant Effects in Rat Liver and Kidneys: A Study on Females

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