Examination of certain single-nucleotide polymorphisms of interleukins 1A and 1B in medication-related osteonecrosis of the jaw — An ambirectional cohort study

Szentpeteri, Szofia; Kosa, Janos; Juhasz, Huba Donat; Deak, Gyorgy; Nemeth, Zsolt; Lakatos, Peter; Vaszilko, Mihaly

doi:10.1016/j.jcms.2024.06.007

Journal of Cranio-Maxillofacial Surgery

2024

DOI: 10.1016/j.jcms.2024.06.007

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Examination of certain single-nucleotide polymorphisms of interleukins 1A and 1B in medication-related osteonecrosis of the jaw — An ambirectional cohort study

Szofia Szentpeteri,

Janos Kosa,

Huba Donat Juhasz

et al.

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Cited by 2 publications

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Genetic Background of Medication-Related Osteonecrosis of the Jaw: Current Evidence and Future Perspectives

Bojtor,

Balla,

Vaszilko

et al. 2024

IJMS

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Medication-related osteonecrosis of the jaw (MRONJ) is a rare side effect of antiresorptive drugs that significantly hinders the quality of life of affected patients. The disease develops in the presence of a combination of factors. Important pathogenetic factors include inflammation, inhibition of bone remodeling, or genetic predisposition. Since the first description of this rare side effect in 2003, a growing body of data has suggested a possible role for genetic factors in the disease. Several genes have been suggested to play an important role in the pathogenesis of MRONJ such as SIRT1, VEGFA, and CYP2C8. With the development of molecular biology, newer methods such as miRNA and gene expression studies have been introduced in MRONJ, in addition to methods that can examine the base sequence of the DNA. Describing the complex genetic background of MRONJ can help further understand its pathophysiology as well as identify new therapeutic targets to better manage this adverse drug reaction.

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Examination of certain single-nucleotide polymorphisms of interleukins 1A and 1B in medication-related osteonecrosis of the jaw — An ambirectional cohort study

Cited by 2 publications

References 28 publications

Pamidronic acid

Pamidronic acid

Genetic Background of Medication-Related Osteonecrosis of the Jaw: Current Evidence and Future Perspectives

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