Examining associations between genetic and neural risk for externalizing behaviors in adolescence and early adulthood

Brislin, Sarah J.; Salvatore, Jessica E.; Meyers, Jacquelyn L.; Kamarajan, Chella; Plawecki, Martin H.; Edenberg, Howard J.; Kuperman, Samuel; Tischfield, Jay A.; Hesselbrock, Victor; Anokhin, Andrey P.; Chorlian, David B.; Schuckit, Marc A.; Nürnberger, John I.; Bauer, Lance O.; Pandey, Gayathri; Pandey, Ashwini K.; Kramer, John; Chan, Grace; Porjesz, Bernice; Dick, Danielle M.

doi:10.1017/s0033291723001174

Cited by 2 publications

(2 citation statements)

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“…131 In another recent study, COGA researchers examined the associations between P3 amplitude, PGS for behavioral dyscontrol (EXT PGS), and self‐report of externalizing behaviors. 122 , 132 Investigators examined these associations among adolescents (12–17) and young adults (18–32) of both European and African ancestry. Both the EXT PGS and P3 amplitude were associated with externalizing behaviors, but the EXT PGS was not significantly associated with P3 amplitude.…”

Section: How Do Neural Signatures Associated With Aud ...mentioning

confidence: 99%

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The collaborative study on the genetics of alcoholism: Brain function

Meyers,

Brislin,

Kamarajan

et al. 2023

Genes Brain and Behavior

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Alcohol use disorder (AUD) and related health conditions result from a complex interaction of genetic, neural and environmental factors, with differential impacts across the lifespan. From its inception, the Collaborative Study on the Genetics of Alcoholism (COGA) has focused on the importance of brain function as it relates to the risk and consequences of alcohol use and AUD, through the examination of noninvasively recorded brain electrical activity and neuropsychological tests. COGA's sophisticated neurophysiological and neuropsychological measures, together with rich longitudinal, multi‐modal family data, have allowed us to disentangle brain‐related risk and resilience factors from the consequences of prolonged and heavy alcohol use in the context of genomic and social‐environmental influences over the lifespan. COGA has led the field in identifying genetic variation associated with brain functioning, which has advanced the understanding of how genomic risk affects AUD and related disorders. To date, the COGA study has amassed brain function data on over 9871 participants, 7837 with data at more than one time point, and with notable diversity in terms of age (from 7 to 97), gender (52% female), and self‐reported race and ethnicity (28% Black, 9% Hispanic). These data are available to the research community through several mechanisms, including directly through the NIAAA, through dbGAP, and in collaboration with COGA investigators. In this review, we provide an overview of COGA's data collection methods and specific brain function measures assessed, and showcase the utility, significance, and contributions these data have made to our understanding of AUD and related disorders, highlighting COGA research findings.

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Section: How Do Neural Signatures Associated With Aud ...mentioning

confidence: 99%

“…The results suggest that genetic liability for behavioral dyscontrol and P3 amplitude are each uniquely contributing to the expression of externalizing behavior, perhaps indexing different facets of externalizing risk. 132 …”

Section: How Do Neural Signatures Associated With Aud ...mentioning

confidence: 99%