Examining Reactivity and Recovery Patterns of Pain-Evoked Cortisol and Alpha-Amylase Trajectories: Relations Between Psychological Markers of Risk and Resilience

Terry, Ellen L.; Meng, Lingsong; Huo, Zhiguang; Bartley, Emily J.

doi:10.1016/j.jpain.2024.01.007

The Journal of Pain

2024

DOI: 10.1016/j.jpain.2024.01.007

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Examining Reactivity and Recovery Patterns of Pain-Evoked Cortisol and Alpha-Amylase Trajectories: Relations Between Psychological Markers of Risk and Resilience

Ellen L. Terry,

Lingsong Meng,

Zhiguang Huo

et al.

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2024

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When thinking about pain contributes to suffering: the example of pain catastrophizing

Haythornthwaite,

Campbell,

Edwards

2024

Pain

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The extensive literature on the potent role negative thoughts about pain have on the experience of pain and pain-related suffering has documented associations with important neurobiological processes involved in amplifying nociceptive signals. We focus this review on pain catastrophizing (pCAT)— appraisals of pain as threatening, overwhelming, and unmanageable— and review the evidence that these thoughts are learned in childhood through experience and observation of others, particularly caretakers and parents. For children who have learned pCAT, repeated exposures to pain over time activate pCAT and likely contribute to further amplification of pain through changes in the neurobiological pain regulatory systems, which overlap with those regulating the stress response. We propose that repeated pain and stress exposures throughout childhood, adolescence, and into adulthood alter the neurobiology of pain via a repetitive positive feedback loop that increases risk for heightened pain sensitivity over time with repeated exposures. At some point, often precipitated by an acute episode of pain and possibly influenced by allostatic load, pCAT contributes to persistence of episodic or acute pain and exacerbates pain-related suffering. This developmental trajectory is not inevitable, as the impact of pCAT on pain and pain-related suffering can be influenced by various factors. We also present future directions for work in this area.

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When thinking about pain contributes to suffering: the example of pain catastrophizing

Haythornthwaite,

Campbell,

Edwards

2024

Pain

View full text Add to dashboard Cite

show abstract

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Examining Reactivity and Recovery Patterns of Pain-Evoked Cortisol and Alpha-Amylase Trajectories: Relations Between Psychological Markers of Risk and Resilience

Cited by 1 publication

References 86 publications

When thinking about pain contributes to suffering: the example of pain catastrophizing

When thinking about pain contributes to suffering: the example of pain catastrophizing

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