2016
DOI: 10.1038/srep32808
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Exceedingly Higher co-loading of Curcumin and Paclitaxel onto Polymer-functionalized Reduced Graphene Oxide for Highly Potent Synergistic Anticancer Treatment

Abstract: Metastasis of lung carcinoma to breast and vice versa accounts for one of the vast majority of cancer deaths. Synergistic treatments are proven to be the effective method to inhibit malignant cell proliferation. It is highly advantageous to use the minimum amount of a potent toxic drug, such as paclitaxel (Ptx) in ng/ml together with a natural and safe anticancer drug, curcumin (Cur) to reduce the systemic toxicity. However, both Cur and Ptx suffer from poor bioavailability. Herein, a drug delivery cargo was e… Show more

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Cited by 89 publications
(61 citation statements)
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“…Furthermore, Bcl‐2 family member proteins, including proapoptotic (eg, Bax, Bak, Bad, and Bid) and antiapoptotic members (eg, Bcl‐2, Bcl‐xL, and Mcl‐1) regulated the mitochondrial outer membrane permeability, thus governing the intrinsic pathway of cell death, which is referred to as the mitochondrial pathway. The activation of cytotoxic stimuli through ROS or other tumor suppressors indicate the release of proapoptotic proteins from the mitochondria including cytochrome c, thereby inducing mitochondrial permeability transition, which is associated with a decrease in MMP . The generation of ROS, however, may result in an imbalance in the intracellular redox status, which then allows ROS to mediate MMP transition, mitochondrial release of cytochrome c into the cytosol, and caspase activation.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Furthermore, Bcl‐2 family member proteins, including proapoptotic (eg, Bax, Bak, Bad, and Bid) and antiapoptotic members (eg, Bcl‐2, Bcl‐xL, and Mcl‐1) regulated the mitochondrial outer membrane permeability, thus governing the intrinsic pathway of cell death, which is referred to as the mitochondrial pathway. The activation of cytotoxic stimuli through ROS or other tumor suppressors indicate the release of proapoptotic proteins from the mitochondria including cytochrome c, thereby inducing mitochondrial permeability transition, which is associated with a decrease in MMP . The generation of ROS, however, may result in an imbalance in the intracellular redox status, which then allows ROS to mediate MMP transition, mitochondrial release of cytochrome c into the cytosol, and caspase activation.…”
Section: Discussionmentioning
confidence: 99%
“…tion, which is associated with a decrease in MMP. 45 The generation of ROS, however, may result in an imbalance in the intracellular redox status, which then allows ROS to mediate MMP transition, mitochondrial release of cytochrome c into the cytosol, and caspase activation. The proapoptotic Bax protein induces mitochondrial dysfunction and cytochrome c release from the mitochondrion that interacts with a specific adapter, which in turn activates pro-caspases to active caspases.…”
Section: Discussionmentioning
confidence: 99%
“…The terms GBMs or graphene family nanomaterial (GFNs) includes GR and its derivatives, such as GO, rGO, GR/GO dots (GD/GOD), GR nano-onions, and GR nano-ribbons, as well as fullerenes, and CNTs, see Figure 2 [10,11]. groups, while at the edges of the flakes there are carboxylic groups [18,22,23].…”
Section: Graphene-based Materialsmentioning
confidence: 99%
“…108 Metastasis of lung tumor cells to a secondary location such as breast and vice versa accounts for the vast majority of tumor deaths and presents a major challenge in cancer treatment. 143 One of the main problems of existing chemotherapy for lung tumor is its inadequate efficiency and specificity. Thus, it is always required to develop site-specific and targeted therapies to attain adequate efficacy and reduced side effects.…”
Section: Lung Tumormentioning
confidence: 99%