Exceptionally enhanced Raman optical activity (ROA) of amyloid fibrils and their prefibrillar states

Kolodziejczyk, Aleksandra; Nafie, Laurence A.; Wajda, Aleksandra; Kaczor, Agnieszka

doi:10.1039/d3cc03216g

Chem. Commun.

2023

DOI: 10.1039/d3cc03216g

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Exceptionally enhanced Raman optical activity (ROA) of amyloid fibrils and their prefibrillar states

Aleksandra Kolodziejczyk,

Laurence A. Nafie,

Aleksandra Wajda

et al.

Abstract: We report enormous enhancement of ROA signal detected for mature amyloid fibrils and/or prefibrillar states of different proteins. ROA is observed at earlier stages of fibril formation than VCD and provides access to a broader range of vibrations.

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2024

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Cited by 3 publications

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Vibrational Optical Activity of Amyloid Fibrils

Majka,

Kwiecień,

Kaczor

2024

ChemPlusChem

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Amyloid fibrils are supramolecular systems showing distinct chirality at different levels of their complex multilayered architectures. Due to the regular long‐range chiral organization, amyloid fibrils exhibit the most intense Vibrational Optical Activity (VOA) signal observed up to now, making VOA techniques: Vibrational Circular Dichroism (VCD) and Raman Optical Activity (ROA) very promising tools to explore their structures, handedness and intricate polymorphism. This concept article reviews up‐to‐date experimental studies on VOA application to investigate amyloid fibrils highlighting its future potential in analyzing of these unique supramolecular systems, in particular in the context of biomedicine and nanotechnology.

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Vibrational Optical Activity of Amyloid Fibrils

Majka,

Kwiecień,

Kaczor

2024

ChemPlusChem

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Navigating the future of ROA: Can it surprise us?

Lightner,

Kaczor,

Johannessen

2024

Vibrational Spectroscopy

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The Phenomenon of Vibrational Circular Dichroism Enhancement: A Systematic Survey of Literature Data

Pescitelli,

Di Bari

2024

J. Phys. Chem. B

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While the intensity of vibrational circular dichroism (VCD) signals is commonly 10 4 −10 5 times smaller than that of corresponding IR signals, several kinds of systems display enhanced VCD spectra with g-values (VCD/IR intensity ratio) above 10 −3 and even reaching 5 × 10 −2 in some exceptional cases. These systems include transition metal and lanthanide complexes, protein and peptide fibrils, short oligopeptide gels, crystalline compounds, gels and solution aggregates of organic compounds. We review the literature on VCD enhancement, focusing on collecting and analyzing data on enhanced g-values. Special attention is given to the mechanisms proposed to produce these effects.

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Exceptionally enhanced Raman optical activity (ROA) of amyloid fibrils and their prefibrillar states

Abstract: We report enormous enhancement of ROA signal detected for mature amyloid fibrils and/or prefibrillar states of different proteins. ROA is observed at earlier stages of fibril formation than VCD and provides access to a broader range of vibrations.

Cited by 3 publications

References 19 publications

Vibrational Optical Activity of Amyloid Fibrils

Vibrational Optical Activity of Amyloid Fibrils

Navigating the future of ROA: Can it surprise us?

The Phenomenon of Vibrational Circular Dichroism Enhancement: A Systematic Survey of Literature Data

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