Excess weight in patients with cystic fibrosis: is it always beneficial?

Jiménez, David González; Muñoz-Codoceo, Rosana; Garriga-García, María; Molina-Arias, Manuel; Álvarez-Beltrán, Marina; García-Romero, Ruth; Martínez‐Costa, Cecilia; Meavilla-Olivas, Silvia María; Quintana, Luis Peña; Gutiérrez, Silvia Gallego; Miguelsanz, José Manuel Marugán de; Cortina, Lucrecia Suárez; Ponce, Esperanza Natividad Castejón; Leis, Rosaura; Cruz, Fayna Martín; Martín, Juan José Díaz; García, Carlos Bousoño

doi:10.20960/nh.620

Cited by 14 publications

(5 citation statements)

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“…The Australian registry report found that 18% of adults with pancreatic insufficiency experienced “high BMI” compared to 30% of those with pancreatic sufficiency [4] . A number of studies have found higher rates of overweight and obesity among males [7] , [8] , [9] , [16] , while other studies found no sex differences [12] , [14] . Increasing age is associated with rising BMI among the general population and has been found to predict obesity in some CF studies as well [8] , [9] , [14] .…”

Section: Epidemiologymentioning

confidence: 95%

“…Rates of overweight and obesity may also vary by country. Single center studies performed between 2007 and 2012 in the US, Greece, and Spain report combined rates of overweight and obesity of 23%, 13.2%, and 7%, respectively [10] , [11] , [12] . With growing recognition of overnutrition in CF, national registries have begun reporting overnutrition statistics.…”

Section: Epidemiologymentioning

confidence: 99%

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Obesity in cystic fibrosis

Kutney

Sandouk

Desimone

et al. 2021

Journal of Clinical & Translational Endocrinology

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The prevalence of obesity in patients with cystic fibrosis (CF) is increasing and around one-third of adults with CF are now overweight or obese. The causes of excess weight gain in CF are likely multifactorial, including: adherence to the high-fat legacy diet, reduced exercise tolerance, therapeutic advances, and general population trends. Increased weight has generally been considered favorable in CF, correlating with improved pulmonary function and survival. While the optimal BMI for overall health in CF is unknown, most studies demonstrate minimal improvement in pulmonary function when BMI exceeds 30 kg/m 2 . Dyslipidemia and cardiovascular disease are important co-morbidities of obesity in the general population, but are uncommon in CF. In people with CF, obesity is associated with hypertension and higher cholesterol levels. With longer life expectancy and rising obesity rates, there may be an increase in cardiovascular disease among people with CF in coming years. Overweight CF patients are more likely to be insulin resistant, taking on features of type 2 diabetes. Treating obesity in people with CF requires carefully weighing the metabolic risks of overnutrition with the impact of low or falling BMI on lung function. This article describes current knowledge on the epidemiology, causes, consequence, and treatment of obesity in people with CF.

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Section: Epidemiologymentioning

confidence: 95%

Section: Epidemiologymentioning

confidence: 99%

Obesity in cystic fibrosis

Kutney

Sandouk

Desimone

et al. 2021

Journal of Clinical & Translational Endocrinology

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“…55 Across Europe, the prevalence varies; for example, incidence reports show 13.2% overweight/obese in Greece 56 and 7% in Spain. 57 A recent review illustrated a wide range in obesity prevalence across different settings, but the general consensus is clear, that is, overnutrition is increasing. 58 The cause of this change in nutritional profile (increasing overweight and obesity) is likely to be multifactorial.…”

Section: Changing Nutritional Profilefrom Undernutrition To Overnutri...mentioning

confidence: 99%

“…During the same period, increases in overweight and obesity of between 14.3% and 37% were observed between 2000 and 2020 55 . Across Europe, the prevalence varies; for example, incidence reports show 13.2% overweight/obese in Greece 56 and 7% in Spain 57 . A recent review illustrated a wide range in obesity prevalence across different settings, but the general consensus is clear, that is, overnutrition is increasing 58 …”

Section: Introductionmentioning

confidence: 99%

Evolution of nutritional management in children with cystic fibrosis – a narrative review

Smith,

Lowdon,

Noordhoek

et al. 2024

J Human Nutrition Diet

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Nutrition has played a central role in the management and outcomes of people with cystic fibrosis (pwCF) since the 1970s. Advances in therapies and practices in recent decades have led to a significant change in the patient landscape with dramatic improvements in life expectancy, as well as quality of life, bringing with it new issues. Historically, cystic fibrosis was a condition associated with childhood and malnutrition; however, changes in patient demographics, nutritional assessment and fundamental nutritional management have evolved, and it has become an increasingly prevalent adult disease with new nutritional challenges, including obesity. This paper aims to describe these changes and the impact and challenges they bring for those working in this field. Nutritional professionals will need to evolve, adapt and remain agile to the wider range of situations and support required for a new generation of pwCF. Specialised nutrition support will continue to be required, and it will be additionally important to improve and optimise quality of life and long‐term health.

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“…Patients with PS had between 21 and 36 mg/dL more total cholesterol than PI. This is because patients with PI, even with PERT, have fat malabsorption and chronic inflammation [130].…”

Section: Calcium/phosphorus Ratiosmentioning

confidence: 99%

Calcium, Phosphorus, and Vitamin D Levels in a Series of Cystic Fibrosis Patients: A Cross-Sectional Study

Escobedo-Monge,

Marcos-Temprano,

Parodi-Román

et al. 2024

IJMS

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Cystic fibrosis (CF) is a monogenic disease with different types of mutations that mainly affect the respiratory-digestive system. Calcium (Ca), phosphorus (P), and vitamin D (Vit-D) are essential nutrients for maintaining adequate growth and development, as well as key components in crucial metabolic pathways. Proper diagnosis, treatment, and response are decisive components of precision medicine. Therefore, we conducted a cross-sectional study to evaluate Ca, P, and Vit-D levels along with health and nutritional indicators, regarding their non-skeletal functions, in a series of CF patients. Anthropometric and clinical evaluation, biochemical analysis, dietary survey, and respiratory and pancreatic status were performed. Even though the results showed that all patients had normal dietary and serum Ca levels, 47% of patients had deficient Vit-D intake, 53% of patients had hypovitaminosis D, 35% had insufficient Vit-D levels, 18% had hypophosphatemia, 76% had elevated alkaline phosphate levels, 29% had hypercalciuria, and 65% had hyperphosphaturia. There were no significant differences between homozygous and compound heterozygous patients. Ca, P, and Vit-D levels were associated with body mass index; body composition; physical activity; diet; growth hormones; and the immune, liver, and kidney systems. We suggest a periodically evaluation of Ca and P losses.

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Excess weight in patients with cystic fibrosis: is it always beneficial?

Abstract: Prevalence of overweight and obese was 6 and 1%. Excess weight status does not offer any benefit in pulmonary function in comparison to normally nourished patients.

Cited by 14 publications

References 0 publications

Obesity in cystic fibrosis

Obesity in cystic fibrosis

Evolution of nutritional management in children with cystic fibrosis – a narrative review

Calcium, Phosphorus, and Vitamin D Levels in a Series of Cystic Fibrosis Patients: A Cross-Sectional Study

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