Excessive Supraventricular Ectopic Activity and Adverse Cardiovascular Outcomes: a Systematic Review and Meta-analysis

Meng, Lei; Tsiaousis, Georgios; He, Jinli; Tse, Gary; Antoniadis, Antonios; Korantzopoulos, Panagiotis; Letsas, Κonstantinos P.; Baranchuk, Adrián; Qi, Wanting; Zhang, Zhiwei; Liu, Enzhao; Xu, Gang; Xia, Yunlong; Li, Guangping; Roever, Leonardo; Lip, Gregory Y.H.; Fragakis, Nikolaos; Liu, Tong

doi:10.1007/s11883-020-0832-4

Cited by 20 publications

(14 citation statements)

References 57 publications

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“…In a meta-analysis of 5 studies (N=7545 patients), excessive supraventricular ectopic activity, defined as the presence of either ≥30 premature atrial contractions per hour or any runs of ≥20 premature atrial contractions, was associated with an increased risk of stroke (HR, 2.19 [95% CI, 1.24–4.02]). 79…”

Section: Stroke Risk Factorsmentioning

confidence: 99%

Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association

Tsao¹,

Aday²,

Almarzooq³

et al. 2022

Circulation

3,787

2,336

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Background: The American Heart Association, in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, diet, and weight) and health factors (cholesterol, blood pressure, and glucose control) that contribute to cardiovascular health. The Statistical Update presents the latest data on a range of major clinical heart and circulatory disease conditions (including stroke, congenital heart disease, rhythm disorders, subclinical atherosclerosis, coronary heart disease, heart failure, valvular disease, venous disease, and peripheral artery disease) and the associated outcomes (including quality of care, procedures, and economic costs). Methods: The American Heart Association, through its Statistics Committee, continuously monitors and evaluates sources of data on heart disease and stroke in the United States to provide the most current information available in the annual Statistical Update. The 2022 Statistical Update is the product of a full year’s worth of effort by dedicated volunteer clinicians and scientists, committed government professionals, and American Heart Association staff members. This year’s edition includes data on the monitoring and benefits of cardiovascular health in the population and an enhanced focus on social determinants of health, adverse pregnancy outcomes, vascular contributions to brain health, and the global burden of cardiovascular disease and healthy life expectancy. Results: Each of the chapters in the Statistical Update focuses on a different topic related to heart disease and stroke statistics. Conclusions: The Statistical Update represents a critical resource for the lay public, policymakers, media professionals, clinicians, health care administrators, researchers, health advocates, and others seeking the best available data on these factors and conditions.

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Section: Stroke Risk Factorsmentioning

confidence: 99%

Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association

Tsao¹,

Aday²,

Almarzooq³

et al. 2022

Circulation

3,787

2,336

View full text Add to dashboard Cite

show abstract

“…In many studies, supraventricular extrasystoles (SVESs) and ventricular extrasystoles (VESs) are associated with adverse cardiovascular outcomes [ 11 ]. Therefore, SVESs and VESs per hour were defined as cardiac events.…”

Section: Methodsmentioning

confidence: 99%

Rescue Operations Lead to Increased Cardiovascular Stress in HEMS Crew Members: A Prospective Pilot Study of a German HEMS Cohort

Strauß

Dahmen

Hutter

et al. 2021

JCM

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Helicopter emergency medical service (HEMS) is an essential part of prehospital emergency medicine. The working conditions lead to high physical stress, especially in rescue operations. The study aimed to determine the cardiovascular stress profile during rescue situations in HEMS crew members. Twenty-one HEMS crew members (male n = 20) participated in the prospective study. Heart rate, blood pressure and long-term ECG measurements were recorded during the whole operation day. The changes of measurements during rescue operation (52 operations in total) were compared to these of standby time. Rescue operations lead to increased load on the cardiovascular system, as expressed by significantly higher blood pressure, heart rate values and rate of cardiac events compared to standby time. Of special note, the difference in systolic blood pressure mean was 7.4 ± 9.0 mmHg (CI [5.1; 9.7], p < 0.001). Maximal heart rate was on average 33.7 bpm higher during rescue operation than in the standby time (CI [26.2; 40.8], p < 0.001). Cardiac events occurred significantly more frequently during the period of rescue operation than in standby time hours (p = 0.02). The results reported a significant load on the cardiovascular system during rescue operations in HEMS crew members. Therefore, it is necessary to carry out a risk stratification of the HEMS crew members to prevent cardiovascular risk and events.

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“…Three recent meta-analyses assessed the association between PACs, morbidity, and mortality ( Himmelreich et al, 2019 ; Huang et al, 2020 ; Meng et al, 2020 ). The presence of a significant PAC burden is associated with a 3-fold increase in AF occurrence and is independently associated with a 2-fold increase.…”

Section: Physiopathology and Epidemiology Of Nonsustained Atrial Arrh...mentioning

confidence: 99%

“…Both premature atrial contractions (PACs) and nonsustained atrial firing are frequent conditions. Historically considered a benign phenomenon, challenging data have highlighted its impact on morbidity and mortality, whether in terms of atrial fibrillation (AF), ischemic stroke or all-cause and cardiovascular mortality ( Himmelreich et al, 2019 ; Huang et al, 2020 ; Meng et al, 2020 ). However, the diagnostic and therapeutic management of ectopic atrial rhythm is not yet precisely standardized ( Farinha et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Premature atrial contractions: A predictor of atrial fibrillation and a relevant marker of atrial cardiomyopathy

Guichard

Guasch²,

Roche³

et al. 2022

Front. Physiol.

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An increased burden of premature atrial contractions (PACs) has long been considered a benign phenomenon. However, strong evidence of their involvement in the occurrence of atrial fibrillation (AF), ischemic stroke, and excess mortality suggests the need for management. The central question to be resolved is whether increased ectopic atrial rhythm is only a predictor of AF or whether it is a marker of atrial cardiomyopathy and therefore of ischemic stroke. After reviewing the pathophysiology of PACs and its impact on patient prognosis, this mini-review proposes to 1) detail the physiological and clinical elements linking PACs and AF, 2) present the evidence in favor of supraventricular ectopic activity as a marker of cardiomyopathy, and 3) outline the current limitations of this concept and the potential future clinical implications.

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Excessive Supraventricular Ectopic Activity and Adverse Cardiovascular Outcomes: a Systematic Review and Meta-analysis

Cited by 20 publications

References 57 publications

Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association

Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association

Rescue Operations Lead to Increased Cardiovascular Stress in HEMS Crew Members: A Prospective Pilot Study of a German HEMS Cohort

Premature atrial contractions: A predictor of atrial fibrillation and a relevant marker of atrial cardiomyopathy

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