Excitotoxicity and Glaucoma

Ishikawa, Makoto; Yoshitomi, Takeshi; Izumi, Yukitoshi

doi:10.5772/57605

Ophthalmology - Current Clinical and Research Updates 2014

DOI: 10.5772/57605

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Excitotoxicity and Glaucoma

Makoto Ishikawa¹,

Takeshi Yoshitomi²,

Yukitoshi Izumi³

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2018

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Cited by 1 publication

References 104 publications

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Recent advances in genetically modified animal models of glaucoma and their roles in drug repositioning

et al. 2018

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Glaucoma is one of the leading causes of vision loss in the world. Currently, pharmacological intervention for glaucoma therapy is limited to eye drops that reduce intraocular pressure (IOP). Recent studies have shown that various factors as well as IOP are involved in the pathogenesis of glaucoma, especially in the subtype of normal tension glaucoma. To date, various animal models of glaucoma have been established, including glutamate/aspartate transporter knockout (KO) mice, excitatory amino acid carrier 1 KO mice, optineurin E50K knock-in mice, DBA/2J mice and experimentally induced models. These animal models are very useful for elucidating the pathogenesis of glaucoma and for identifying potential therapeutic targets. However, each model represents only some aspects of glaucoma, never the whole disease. This review will summarise the benefits and limitations of using disease models of glaucoma and recent basic research in retinal protection using existing drugs.

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Recent advances in genetically modified animal models of glaucoma and their roles in drug repositioning

et al. 2018

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Excitotoxicity and Glaucoma

Cited by 1 publication

References 104 publications

Recent advances in genetically modified animal models of glaucoma and their roles in drug repositioning

Recent advances in genetically modified animal models of glaucoma and their roles in drug repositioning

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