Exclusions and Deaths on the Liver Transplant Waiting List

Cadahía, Valle; González-Diéguez, M.L.; Alonso, Pilar; García-Bernardo, Carmen; León, A. Miyar de; Barneo, L; Vázquez, L; González-Pinto, I; Rodrı́guez, Manuel

doi:10.1016/j.transproceed.2010.02.009

Cited by 5 publications

(4 citation statements)

References 10 publications

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Section: Resultsmentioning

confidence: 99%

“…Firstly, patient populations of those studies comprised only of patients who qualified for a liver transplant [6,7]. Secondly, they were followed up for relatively shorter time periods [7]. Finally, the use of Kaplan –Meier survival curves is suboptimal in that situation as multiple outcomes which affect one another, namely, transplantation and death, have to be considered [6].…”

Section: Resultsmentioning

confidence: 99%

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Survival of patients with alcoholic and cryptogenic cirrhosis without liver transplantation: a single center retrospective study

Senanayake

Niriella

Weerasinghe³

et al. 2012

BMC Res Notes

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BackgroundThere is no recent data addressing the long term survival of cirrhosis patients without transplantation, but with the availability of optimal pharmacological and endoscopic therapies. We compared the long term transplant free survival of alcoholic (AC) and cryptogenic (CC) cirrhosis patients in a setting where liver transplantation was, until very recently, not available. AC and CC patient details were extracted from our database, maintained since 1995. For those who had not attended clinics within the past 4 weeks, the patient or families were contacted to obtain survival status. If deceased, cause of death was ascertained from death certificates and patient records. Survival was compared using Kaplan-Meier curves.ResultsComplete details were available in 549/651 (84.3%) patients (AC 306, CC 243). Mean follow up duration (SD) (months) was 29.9 (32.6). 82/96 deaths (85.4%) among AC and 80/94 deaths (85.1%) among CC were liver related. Multivariate analysis showed age at diagnosis and Child’s class predicted overall survival among all groups. The median survival in Child’s class B and C were 53.5 and 25.3 months respectively. Survival was similar among AC and CC. Among AC survival was improved by abstinence [HR = 0.63 (95% CI: 0.40-1.00)] and was worse with diabetes [HR=1.59 (95% CI: 1.02- 2.48)] irrespective of alcohol status.ConclusionsThe overall survival of AC was similar to CC. Death in both groups were predominantly liver related, and was predicated by age at diagnosis and Child class. Among AC, presence of diabetes and non-abstinence from alcohol were independent predictors for poor survival.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Survival of patients with alcoholic and cryptogenic cirrhosis without liver transplantation: a single center retrospective study

Senanayake

Niriella

Weerasinghe³

et al. 2012

BMC Res Notes

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“…A implementação do MELD, ou seja, do modelo para doença hepática em estágio final como um sistema de alocação de órgãos tem reduzido a mortalidade em fila de espera. 10 Diante disso, as equipes de transplante, as quais apresentam caráter multidisciplinar, têm somado esforços de seus integrantes a fim de preparar candidatos e receptores para o enfrentamento de um procedimento tão complexo como o transplante de fígado.…”

Section: Resultsunclassified

Características Sócio-Demográficas Entre Candidatos E Receptores De Transplante De Fígado De Um Centro Transplantador Do Interior Paulista

Mendes

Ziviani

Rossin

et al. 2010

bjt

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Objetivo: Caracterizar candidatos e receptores de transplante de fígado quanto às condições sociais e demográficas em um programa de transplante de fígado do interior paulista. Método: Realizado um estudo prospectivo, monocêntrico, do tipo survey entre candidatos e receptores de transplante de fígado. A amostra de conveniência constou de 100 indivíduos, 50 candidatos e 50 receptores de transplante de fígado, os quais responderam uma entrevista estruturada. Resultados: Dos 50 candidatos a transplante de fígado entrevistados, a maioria era CHILD B e MELD médio de 15,3. A cirrose hepática de causa alcoólica e viral esteve presente na maioria dos pacientes. Quanto ao tempo de evolução da doença crônica do fígado, a média foi de 8,62 ± 7,59 anos. O tempo médio de inscrição na fila de espera foi de 1064,7± 706,32 dias. Dos 50 receptores de fígado, o tempo médio após o transplante foi de 868,4 ± 761,88 dias. A maior parte fazia uso de terapia imunossupressora com tacrolimus. Em relação aos problemas de saúde apresentados, a maioria (50%) referiu hipertensão arterial e/ou diabetes mellitus. Conclusão: Observou-se a importância do planejamento da assistência à saúde direcionada às necessidades específicas dos pacientes, além da necessidade de outros estudos que possibilitem ampliar o conhecimento a respeito dessa clientela.

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“…This decision‐analysis model was constructed using TreeAge Pro Version 2015 (TreeAge Software, Inc, Williamstown, MA, USA). Assuming each studied cohort received treatment (one prior to LT, one preemptively prior to HCV recurrence, and the other post‐LT after HCV recurrence), the probability at each decision point was determined (Table ) . Using these assumptions, a final decision point was constructed based upon the varied decision tree.…”

Section: Methodsmentioning

confidence: 99%

Optimal timing for hepatitis C therapy in US patients eligible for liver transplantation: a cost‐effectiveness analysis

Njei

McCarty

Fortune

et al. 2016

Aliment Pharmacol Ther

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Exclusions and Deaths on the Liver Transplant Waiting List

Cited by 5 publications

References 10 publications

Survival of patients with alcoholic and cryptogenic cirrhosis without liver transplantation: a single center retrospective study

Survival of patients with alcoholic and cryptogenic cirrhosis without liver transplantation: a single center retrospective study

Características Sócio-Demográficas Entre Candidatos E Receptores De Transplante De Fígado De Um Centro Transplantador Do Interior Paulista

Optimal timing for hepatitis C therapy in US patients eligible for liver transplantation: a cost‐effectiveness analysis

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