Exercise ameliorates deficits in neural microstructure in a Disc1 model of psychiatric illness

Barnett, Brian R.; Anderson, Jacqueline M.; Torres-Velázquez, Maribel; Yi, Sue Y.; Rowley, Paul A.; Yu, John‐Paul J.

doi:10.1016/j.mri.2019.05.021

Cited by 7 publications

(14 citation statements)

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“…An increasing number of studies demonstrate that proper exercise is beneficial for depression and anxiety symptoms, including those in patients with PTSD (Rebar et al, 2015;Schuch et al, 2016). Evidence exists that impaired adult hippocampal neurogenesis (AHN) is related to various neurological diseases, including PTSD, depression, and Alzheimer's disease (Gao et al, 2017;Barnett et al, 2019). Thus, enhancing AHN can effectively reduce the mood symptoms of the depression model, improve memory resolution, and avoid the recovery of panic experience (Sahay et al, 2011;Hill et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Mind–Body Exercises for PTSD Symptoms, Depression, and Anxiety in Patients With PTSD: A Systematic Review and Meta-Analysis

Zhu

et al. 2022

Front. Psychol.

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ObjectivesThis study aims to systematically analyze the effects of mind–body exercises on post-traumatic stress disorder (PTSD) symptoms, depression, and anxiety in patients with PTSD. Furthermore, it intends to provide scientific evidence-based exercise prescriptions.MethodsChinese (i.e., China National Knowledge Infrastructure, VIP Database for Chinese Technical Periodicals, and Wanfang) and English (i.e., Web of Science, PubMed, the Cochrane Library, and EMBASE) databases were used as data sources to search for studies on the effects of mind–body exercises on symptoms associated with patients with PTSD from January 1980 to November 2020. After a rigorous screening, 16 eligible randomized controlled trials (RCTs) were included in the meta-analysis.ResultsMind–body exercises exerted a significant effect on PTSD symptoms [standard mean difference (SMD) = −0.41, 95% confidence interval (CI) −0.64 to −0.19, p < 0.001], depression (SMD = −0.35, 95% CI: −0.55 to −0.15, p < 0.001), and anxiety (SMD = −0.31, 95% CI: −0.74 to −0.12, p < 0.001) among patients with PTSD. Subgroup analysis demonstrated that 60–150 min per session for 8–16 weeks of mindfulness was more effective in improving symptoms in patients with PTSD under 45 years of age compared with other subgroups. For depression, 150–180 min of yoga exercises once per week was effective. For anxiety, the frequency, timing, duration, and type of mind–body exercises that are most effective in relieving anxiety in patients with PTSD cannot be determined at this time due to the limited number of eligible RCTs.ConclusionsMind–body exercises were found to be significantly effective in improving PTSD symptoms, depression, and anxiety in patients with PTSD. Therefore, they can be used as an adjunct to intervention for symptoms of patients with PTSD. However, this conclusion requires further confirmation through additional scientific and objective RCTs.Systematic Review Registration:Unique Identifier: INPLASY2020120072.

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Section: Discussionmentioning

confidence: 99%

Mind–Body Exercises for PTSD Symptoms, Depression, and Anxiety in Patients With PTSD: A Systematic Review and Meta-Analysis

Zhu

et al. 2022

Front. Psychol.

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“…Therefore, we can perform the necessary mechanistic studies that cannot be executed in humans in this model.Two studies have used ex vivo DTI to evaluate running exercise’s effects on rat disease models. One such study using a short-term (4 weeks) treadmill exercise protocol in Disc1 sv Δ 2 rats, a genetic model of schizophrenia, reported significant differences in the neural microstructures – specifically the neocortex, basal ganglia, corpus callosum, and external capsule, not the hippocampus – of sedentary versus exercised Disc1 sv Δ 2 animals but observed no such differences between sedentary and exercised control animals [ 42 ]. The other study employed ex vivo DTI to investigate the neuroprotective effect of running exercise in a cranial radiation therapy rat model and found that exercise increased whole brain volume, the number of fibers in the entire brain, and global connectomics.…”

Section: Discussionmentioning

confidence: 99%

Diffusion tensor-MRI detects exercise-induced neuroplasticity in the hippocampal microstructure in mice

Islam

Luo

Valaris

et al. 2020

BPL

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Background: Despite considerable research on exercise-induced neuroplasticity in the brain, a major ongoing challenge in translating findings from animal studies to humans is that clinical and preclinical settings employ very different techniques. Objective: Here we aim to bridge this divide by using diffusion tensor imaging MRI (DTI), an advanced imaging technique commonly applied in human studies, in a longitudinal exercise study with mice. Methods: Wild-type mice were exercised using voluntary free-wheel running, and MRI scans were at baseline and after four weeks and nine weeks of running. Results: Both hippocampal volume and fractional anisotropy, a surrogate for microstructural directionality, significantly increased with exercise. In addition, exercise levels correlated with effect size. Histological analysis showed more PDGFRα+ oligodendrocyte precursor cells in the corpus callosum of running mice. Conclusions: These results provide compelling in vivo support for the concept that similar adaptive changes occur in the brains of mice and humans in response to exercise.

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“…vational designs may be employed to assess potential sources of this phenomenon. For example, F-ISO may exhibit diurnal changes, or may be sensitive to physical activity 43,44. Lesions could be another measurable source of F-ISO instability, although we note that this would not be a contributing factor to poor repeatability in HCs.…”

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confidence: 84%

Repeatability of neurite orientation dispersion and density imaging in patients with traumatic brain injury

Mueller

Goodman

Nenert

et al. 2023

Journal of Neuroimaging

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Background and PurposeThe aim of this study was to assess the repeatability of neurite orientation dispersion and density imaging in healthy controls (HCs) and traumatic brain injury (TBI).MethodsSeventeen HCs and 48 TBI patients were scanned twice over 18 weeks with diffusion imaging. Orientation dispersion (ODI), neurite density (NDI), and the fraction of isotropic diffusion (F‐ISO) were quantified in regions of interest (ROIs) from a gray matter, subcortical, and white matter atlas and compared using the coefficient of variation for repeated measures (CVrep), which quantifies the expected percent change on repeated measurement. We used a modified signed likelihood ratio test (M‐SLRT) to compare the CVrep between groups in each ROI while correcting for multiple comparisons.ResultsNDI exhibited excellent repeatability in both groups; the only group difference was found in the fusiform gyrus, where HCs exhibited better repeatability (M‐SLRT = 9.463, p = .0021). ODI also had excellent repeatability in both groups, although repeatability was significantly better in HCs in 16 cortical ROIs (p < .0022) and in the bilateral white matter and bilateral cortex (p < .0027). F‐ISO exhibited relatively poor repeatability in both groups, with few group differences.ConclusionOverall, the repeatability of the NDI, ODI, and F‐ISO metrics over an 18‐week period is acceptable for assessing the effects of behavioral or pharmacological interventions, though caution is advised when assessing F‐ISO changes over time.

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Exercise ameliorates deficits in neural microstructure in a Disc1 model of psychiatric illness

Cited by 7 publications

References 83 publications

Mind–Body Exercises for PTSD Symptoms, Depression, and Anxiety in Patients With PTSD: A Systematic Review and Meta-Analysis

Mind–Body Exercises for PTSD Symptoms, Depression, and Anxiety in Patients With PTSD: A Systematic Review and Meta-Analysis

Diffusion tensor-MRI detects exercise-induced neuroplasticity in the hippocampal microstructure in mice

Repeatability of neurite orientation dispersion and density imaging in patients with traumatic brain injury

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