2020
DOI: 10.1007/978-981-15-1792-1_15
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Exercise and Osteoarthritis

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Cited by 21 publications
(17 citation statements)
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“…Osteoarthritis (OA) is a common joint disease with destruction of articular cartilages [ 1 ]. OA has seriously affected the life quality of human beings, and there is no effective strategy for treatment of OA [ 2 ]. Chondrocyte dysfunction is the leading cause of cartilage degeneration and OA progression [ 3 ].…”
Section: Introductionmentioning
confidence: 99%
“…Osteoarthritis (OA) is a common joint disease with destruction of articular cartilages [ 1 ]. OA has seriously affected the life quality of human beings, and there is no effective strategy for treatment of OA [ 2 ]. Chondrocyte dysfunction is the leading cause of cartilage degeneration and OA progression [ 3 ].…”
Section: Introductionmentioning
confidence: 99%
“…It is characterized by progressive degeneration, joint hyperplasia, joint space narrowing, and extracellular matrix (ECM) metabolism and is the most prevalent and disabling form of arthritis worldwide 2,3 . The etiology of OA is mainly related to age, strain, obesity, trauma, joint deformities, and congenital abnormalities of joints 4 . Progression of OA is also governed by a multifactorial pathway that is not yet fully elucidated and understood.…”
Section: Introductionmentioning
confidence: 99%
“…2,3 The etiology of OA is mainly related to age, strain, obesity, trauma, joint deformities, and congenital abnormalities of joints. 4 Progression of OA is also governed by a multifactorial pathway that is not yet fully elucidated and understood. Reduced chondrocyte activity and accelerated development of OA are reportedly due to autophagy and mitochondrial dysfunction.…”
mentioning
confidence: 99%
“…It is clinically characterized by destruction of articular cartilage, pain, and stiffness, which ultimately lead to immobility and the reduced quality of life for patients, thereby increasing the social and medical burden [ 2 ]. Artificial joint replacement is mainly suitable for advanced patients with severe symptoms, but there is still a lack of substantial progress in the treatment of early and midstage patients [ 3 ]. In-depth study of the pathogenesis of osteoarthritis has important clinical significance for improving the level of diagnosis and treatment of osteoarthritis.…”
Section: Introductionmentioning
confidence: 99%