Exercise attenuates alveolar bone loss and anxiety‐like behaviour in rats with periodontitis

Andrade, Eric Francelino; Orlando, Débora Ribeiro; Gomes, Júlia Ariana Souza; Foureaux, Renata de Carvalho; Costa, R. A.; Varaschin, Mary Suzan; Rogatto, Gustavo Puggina; Moura, Rodrigo Ferreira de; Pereira, Luciano José

doi:10.1111/jcpe.12794

Cited by 19 publications

(28 citation statements)

References 79 publications

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“…The placement of ligatures around teeth to initiate periodontal attachment loss has been used in various types of animals. The rat ligature model is widely used (Andrade et al., ; de Molon et al., ) because they are relatively simple, of low cost and the biological response is physiologically similar to that of humans (Klausen, ; Listgarten, ). In the rat, loss of attachment occurs predictably in a 7‐day period (de Almeida et al., ; Graves et al., ).…”

Section: Discussionmentioning

confidence: 99%

Antineoplastic agents exacerbate periodontal inflammation and aggravate experimental periodontitis

Gusman

Ervolino

Theodoro

et al. 2019

J Clinic Periodontology

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Aim This study evaluated the effects of 5‐fluorouracil (5‐FU) and cisplatin (CIS) in healthy periodontal tissues and in the early stages of experimental periodontitis (EP) in rats. Methods One hundred and eighty male rats were divided into three groups, which were submitted to the following systemic treatments: physiological saline solution (PSS); CIS and 5FU. Each group was subdivided into two subgroups: without (NEP) and with (EP) induction of EP. Animals were euthanized at 3, 5 and 7 days post‐treatment. Histological, histometric (percentage of bone in the furcation [PBF]) and immunohistochemical (for tumour necrosis factor‐α, interleukin‐1β and receptor activator of nuclear factor‐κB ligand) analyses were performed. Data were statistically analysed. Results CIS‐NEP and 5FU‐NEP showed more inflammation than PSS‐NEP at 3, 5 and 7 days. CIS‐EP and 5FU‐EP showed more inflammation and lower PBF than PSS‐EP at all periods of evaluation. 5FU‐EP showed lower PBF than CIS‐EP at 5 and 7 days. Conclusion 5‐FU and CIS exacerbated periodontal inflammation and aggravated the progression of EP in its early stages.

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Section: Discussionmentioning

confidence: 99%

Antineoplastic agents exacerbate periodontal inflammation and aggravate experimental periodontitis

Gusman

Ervolino

Theodoro

et al. 2019

J Clinic Periodontology

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“…Also according to Andrade et al (2017) 8 , attenuation of alveolar bone loss and loss of epithelial insertion in trained animals may be related to improved inflammatory profile, as there was an increase in the IL-10 expression (Interleukin-10) and a decrease in TNF-α (tumor necrosis factor-α) in the adjacent tissues of these animals. Besides, the decrease in the TNF-α/IL-10 ratio observed in animals with induced periodontitis undergoing training confirms the improvement in the inflammatory state, as the increase in this ratio is indicative of more severe periodontitis.…”

Section: Discussionmentioning

confidence: 80%

“…When the osteoblast and osteocyte counts were evaluated, a significant decrease was found in the groups undergoing experimental periodontitis, but without any change when associated with physical exercise. Andrade et al (2017) 8 , evaluating animals trained with 1 hour/day swimming sessions for 8 weeks, also found that physical training attenuated alveolar bone loss and levels of loss of epithelial insertion of rats with PD. The distance from the cementoenamel junction to the alveolar bone crest assessed histologically was found to be lower in the group with PD and trained than in the untrained PD group, corroborating with our study regarding the protective effect of physical exercise against the progression of PD.…”

Section: Discussionmentioning

confidence: 98%

“…Physically active individuals are less likely to develop PD compared to physically inactive individuals 7 . However, the effects of physical exercise on parameters of inflammation and alveolar bone loss in individuals with PD have been poorly investigated 8 . The increase of proinflammatory mediators in patients with PD contributes to the increase of alveolar bone loss.…”

Section: Introductionmentioning

confidence: 99%

“…Studies have investigated strategies to prevent the progression of alveolar bone loss, including new approaches to improve the immune response of the host and the strategies known to promote immunomodulation include physical exercise. Long-term physical activity may make the body less susceptible to inflammation and infections, thus becoming a promising factor against the progression of PD 8 . The purpose of this study is to evaluate the behavior of the mandibular bone tissue of rats undergoing physical exercise with or without periodontal disease.…”

Section: Introductionmentioning

confidence: 99%

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Bone Tissue Behavior of Rats With Experimental Periodontitis Subjected to Physical Exercise

Bortolini

Rodrigues

Brandão

et al. 2019

Rev Bras Med Esporte

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Introduction: It is possible that physical activity protects the periodontium by mitigating excessive inflammatory response of the individual. There is some evidence from longitudinal studies and a prospective study demonstrating that physically active adults have experienced a decrease in the risk of periodontitis. To date no study has jointly explored the relationship of physical activity and periodontitis using inflammatory biomarkers. Objective: In this regard, the objective was to assess the bone tissue behavior of rats with experimental periodontitis subjected to aquatic exercise. Methods: Twenty-four male Wistar rats were divided into four groups: 1) without periodontitis and without exercise (CS); 2) without periodontitis and with exercise (CE); 3) with periodontitis and without exercise (DPS); 4) with periodontitis and with exercise (DPE). The animals from groups CE and DPE had swimming sessions for four weeks and the DPS and DPE groups were subjected to ligature-induced periodontitis. After 30 days the animals were sacrificed, and had their right and left hemimandibles removed for radiographic and histological analysis. The data obtained were analyzed and evaluated through ANOVA and Tukey tests. Results: Bone loss in the animals from the DPE group was found to be significantly lower (61.7 ± 2.2; p <0.05) than in those from the DPS group (84.5 ± 1.2; p <0.05), while in terms of the number of osteoblasts (DPS=11.0 ± 1.4; DPE=10.7 ± 5.2) and osteocytes (DPS=17.3 ± 3.1; DPE=19.0 ± 4.4), there was no significant decrease (p <0.05) in the groups subjected to experimental periodontitis, regardless of physical exercise. Conclusion: Physical exercise was found to have a protective effect in relation to bone height and did not influence bone density. Level of evidence II; Therapeutic studies - investigation of treatment results.

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Experimental Periodontitis Increases Anxious Behavior and Worsens Cognitive Aspects and Systemic Oxidative Stress in Wistar Rats

de Castro,

Pereira,

Diniz e Magalhães

et al. 2024

Clinical & Exp Dental Res

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ObjectivesPeriodontitis (PD) has the potential to induce systemic changes that affect both physical and behavioral aspects. These alterations may be associated with changes in both the inflammatory profile and the oxidative stress status of individuals with PD. Therefore, we aimed to evaluate the effects of PD on oxidative stress, as well as on behavioral parameters and cognitive impairment, in a preclinical model.Material and MethodsTwenty‐four male Wistar rats were randomly assigned to PD and sham groups. PD was induced by the ligature protocol for 14 days. Behavioral tests were initiated on the 9th day of the experiment to evaluate anxious behavior and cognition (learning and memory). After euthanasia, oxidative stress was evaluated in the gums, blood, hippocampus, and amygdala. Alveolar bone loss, bone microstructure, and elemental compositions of the mandibular bone were also assessed.ResultsPD increased alveolar bone loss, reduced the calcium and phosphorus content in the mandibular bone, and increased anxiety‐like behavior and cognitive decline (p < 0.05). Furthermore, PD significantly affected the redox balance, as evidenced by increased total antioxidant capacity (TAC) in the gingiva and hippocampus (p < 0.05). It also led to increased lipid peroxidation in the gingiva and erythrocytes (p < 0.05), decreased antioxidant defenses in erythrocytes (superoxide dismutase) and the hippocampus (catalase), and increased antioxidant activity (catalase) in the amygdala (p < 0.05).ConclusionPD resulted in cognitive alterations, including impairments in spatial learning and memory, as well as increased anxious behavior, likely due to redox imbalance in rats.

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Exercise attenuates alveolar bone loss and anxiety‐like behaviour in rats with periodontitis

Abstract: Exercise decreased anxiety behaviour, inflammatory proteins expression and bone loss in rats with PD.

Cited by 19 publications

References 79 publications

Antineoplastic agents exacerbate periodontal inflammation and aggravate experimental periodontitis

Antineoplastic agents exacerbate periodontal inflammation and aggravate experimental periodontitis

Bone Tissue Behavior of Rats With Experimental Periodontitis Subjected to Physical Exercise

Experimental Periodontitis Increases Anxious Behavior and Worsens Cognitive Aspects and Systemic Oxidative Stress in Wistar Rats

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