Exercise increases serum endostatin levels in female and male patients with diabetes and controls

Abstract

Background: Type 2 diabetes mellitus (T2DM) is often associated with atherosclerotic changes in coronary vessels, most notably plaques. The angiostatic parameter endostatin is able to inhibit angiogenesis in tissue as well as in plaques and therefore plays an important role in physiological and pathological neovascularisation. The aim of the present study was to investigate sex-specific differences and the influence of exercise on circulating endostatin levels in patients suffering from diabetes, and control subjects. Methods: In total, 42 T2DM-patients and 45 control subjects were investigated. They underwent a graded physical stress test (ergometry). Serum endostatin levels were measured in venous blood at rest and directly after reaching maximum workload. Results: Females showed significantly higher endostatin levels at baseline measurements compared to men, independently of their underlying disease. In both female and male T2DM-patients endostatin levels were significantly lower compared to controls. Both groups and sexes showed a significant increase of endostatin after physical stress, whereas the extent of endostatin-increase was between 10.59-15.05%.

Endostatin and osteopontin are elevated in patients with both coronary artery disease and aortic valve calcification

“…Its circulating amounts are influenced by several secondary circumstances such as the presence of diabetes [8] or physical activity [9]. Chalajour et al investigated the angiogenic response of valvular endothelial cells to aortic valve stenosis in an ex vivo model of aortic leaflets and showed that sprouts from stenotic valves exhibited endostatin [10].…”

Effect of Endostatin and Insulin-Like Growth Factor-1 on Angiogenesis in Patients With Acute Myocardial Infarction With Obesity Under the Influence of Zofenopril

“…Obesity, low physical activity, diabetes mellitus can affect the level of endostatin in serum [17,18]. Disrupted endostatin levels in the blood serum are associated with cerebrovascular diseases, organ damage in hypertension [19].…”

Serum endostatin level as a marker for coronary artery calcification in type 2 diabetic patients

“…Diabetes [13], physical activity [14], inflammation, and obesity can affect the circulating serum levels of ES. Disturbed ES serum level is associated with cerebrovascular diseases [15], organ damage in hypertension [16], and can predict cardiovascular mortality in elderly people [17].…”