Exercise-induced oxidative stress in overweight adolescent girls: roles of basal insulin resistance and inflammation and oxygen overconsumption

Youssef, Hala; Groussard, Carole; Pincemaïl, Joël; Moussa, Elie; Jacob, Christophe; Lemoine, Sophie; Zind, Marguerite; Defraigne, Jean-Olivier; Cillard, Josiane; Delamarche, Paul; Gratas-Delamarche, Arlette

doi:10.1038/ijo.2009.49

Cited by 22 publications

(19 citation statements)

References 44 publications

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“…oxLDL was determined spectrophotometrically with a competitive enzyme-linked immunosorbent assay (Immunodiagnostik). F2-IsoP was measured by liquid chromatography mass spectrometry as described previously (Youssef et al 2009). …”

Section: Pro/antioxidant Statusmentioning

confidence: 99%

Beneficial effects of an intradialytic cycling training program in patients with end-stage kidney disease

Groussard

Rouchon-Isnard

Coutard

et al. 2015

Appl. Physiol. Nutr. Metab.

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In chronic kidney disease (CKD), oxidative stress (OS) plays a central role in the development of cardiovascular diseases. This pilot program aimed to determine whether an intradialytic aerobic cycling training protocol, by increasing physical fitness, could reduce OS and improve other CKD-related disorders such as altered body composition and lipid profile. Eighteen hemodialysis patients were randomly assigned to either an intradialytic training (cycling: 30 min, 55%-60% peak power, 3 days/week) group (EX; n = 8) or a control group (CON; n = 10) for 3 months. Body composition (from dual-energy X-ray absorptiometry), physical fitness (peak oxygen uptake and the 6-minute walk test (6MWT)), lipid profile (triglycerides (TG), total cholesterol, high-density lipoprotein, and low-density lipoprotein (LDL)), and pro/antioxidant status (15-F2α-isoprostanes (F2-IsoP) and oxidized LDL in plasma; superoxide dismutase, glutathione peroxidase, and reduced/oxidized glutathione in erythrocytes) were determined at baseline and 3 months later. The intradialytic training protocol did not modify body composition but had significant effects on physical fitness, lipid profile, and pro/antioxidant status. Indeed, at 3 months: (i) performance on the 6MWT was increased in EX (+23.4%, p < 0.001) but did not change in CON, (ii) plasma TG were reduced in EX (-23%, p < 0.03) but were not modified in CON, and (iii) plasma F2-IsoP concentrations were lower in EX than in CON (-35.7%, p = 0.02). In conclusion, our results show that 30 min of intradialytic training, 3 times per week for 3 months, are enough to exert beneficial effects on the most sensitive and reliable marker of lipid peroxidation (IsoP) while improving CKD-associated disorders (lipid profile and physical fitness). Intradialytic aerobic cycling training represents a useful and easy strategy to reduce CKD-associated disorders. These results need to be confirmed with a larger randomized study.

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Section: Pro/antioxidant Statusmentioning

confidence: 99%

Beneficial effects of an intradialytic cycling training program in patients with end-stage kidney disease

Groussard

Rouchon-Isnard

Coutard

et al. 2015

Appl. Physiol. Nutr. Metab.

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“…A quantitative assessment of dietary and antioxidant intake was provided by means of a diet record. The food records were completed by a nutritional expert and analyzed using a computer dietary analysis (Nutrilog 2.3, Nutrilog SAS, France) employing the Ciqual table of food composition as previously described [31]. This dietary intake assessment aims to evaluate antioxidant intake.…”

Section: Dietary Intakementioning

confidence: 99%

Redox Status of Professional Soccer Players is Influenced by Training Load Throughout a Season

et al. 2016

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International audienceThe purpose of this study was to follow-up the variation of pro-/antioxidant status throughout a whole season in elite professional soccer players from the French league (n = 19, 18.3 +/- 0.6 years) and to examine a possible link between these variations and training load. 5 time points (T1, T2, T3, T4, T5) were proposed to surround crucial periods of training during the whole season: the pre-season training/mid-season periods (T1-T2 and T3-T4), the championship or in-season periods (T2-T3 and T4-T5). At these times, blood samples were collected to measure pro-/antioxidant status (in erythrocytes: the ratio of reduced glutathione/oxidized glutathione, superoxide dismutase and glutathione peroxidase activities, in plasma: alpha-tocopherol, beta-carotene), and dietary intakes were also recorded. Training loads were quantified by the rating of perceived exertion method weekly throughout the season. Pro-/antioxidant-related measurements showed no modifications except for GSH/GSSG ratio, which evolved significantly between season periods: from 36.43 +/- 4.15 (T1) to 115.99 +/- 16.43 (T2) to 91.64 +/- 21.24 (T3) to 202.29 +/- 29.26 (T4) to 59.61 +/- 14.61 (T5). We observed a significant correlation (r(2) = 0.84) between changes in GSH/GSSH ratio and cumulated mean training loads. In conclusion, these results suggest that the redox status of professional soccer players is altered according to training period (in-season periods) and that GSH/GSSH ratio variations are correlated with cumulated training loads

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“…The F2a‐isoprostanes, markers of lipid peroxidation , were extracted from plasma by thermolysis and analyzed by LC/MS as described by Youssef et al .…”

Section: Methodsmentioning

confidence: 99%

Dietary α-lactalbumin supplementation alleviates normocaloric western diet-induced glucose intolerance in Göttingen minipigs

Blat

Vincent

Lefeuvre

et al. 2014

Obesity

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Objective: The pandemic of obesity in Western countries is mainly due to the high-fat, high-energy diet prevailing there. Obesity-associated metabolic disorders are the consequence of fat mass increase leading to altered adipokine secretion, hyperlipemia, oxidant stress, low-grade inflammation, and eventually glucose intolerance. Yet not all people consuming a Western diet become obese, and the question is raised whether these people are also at risk of developing metabolic disorders. Methods: Glucose tolerance, lipid profile, and oxidant and inflammation status were investigated longitudinally in lean G€ ottingen minipigs receiving for 16 weeks either a normal diet (ND), a Western diet (WD), or a Western diet supplemented with a whey protein isolate (WPI) rich in a-lactalbumin known to improve glucose tolerance. ND and WD were supplied isoenergetically. Results: Lean minipigs fed WD displayed glucose intolerance and altered lipid profile after 6 weeks of diet but no inflammation or oxidative stress. Supplementation with WPI alleviated glucose intolerance by improving insulin secretion, but not lipid profile. Conclusions: Western diet consumption is deleterious for glucose tolerance even in the absence of fat mass accretion, and dyslipemia is a major determinant for this metabolic dysfunction. Stimulating insulin secretion with a WPI is an effective strategy to improve glucose tolerance.

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Exercise-induced oxidative stress in overweight adolescent girls: roles of basal insulin resistance and inflammation and oxygen overconsumption

Cited by 22 publications

References 44 publications

Beneficial effects of an intradialytic cycling training program in patients with end-stage kidney disease

Beneficial effects of an intradialytic cycling training program in patients with end-stage kidney disease

Redox Status of Professional Soccer Players is Influenced by Training Load Throughout a Season

Dietary α-lactalbumin supplementation alleviates normocaloric western diet-induced glucose intolerance in Göttingen minipigs

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