Exercise intensity and sex alter neurometabolic, transcriptional, and functional recovery following traumatic brain injury

White, Brishti A.; Ivey, Julia T.; Velazquez-Cruz, Ruth; Oliverio, Robin; Whitehead, Bailey; Pinti, Mark V.; Hollander, John M.; Ma, Lei; Hu, Gwo-Chi; Weil, Zachary M.; Karelina, Kate

doi:10.1016/j.expneurol.2023.114483

Cited by 4 publications

(1 citation statement)

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“…[ 104 ] Similarly, postinjury exercise on neurometabolic, transcriptional, and cognitive outcomes following a TBI in adolescent male and female mice, the study revealed that exercise had intensity- and sex-dependent impacts on cognitive recovery, mitochondrial function, and transcriptional outcome measures. [ 97 ]…”

Section: Lifestyle-based Interventionsmentioning

confidence: 99%

The importance of behavioral interventions in traumatic brain injury

Buccilli,

Alan,

Baha’

et al. 2024

Surgical Neurology International

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Background: Traumatic brain injury (TBI) poses a significant public health concern, profoundly impacting individuals and society. In this context, behavioral interventions have gained prominence as crucial elements in TBI management, addressing the diverse needs of TBI-affected individuals. Methods: A comprehensive literature search was conducted, utilizing databases such as PubMed, Embase, and Scopus. Inclusion criteria encompassed studies focusing on behavioral interventions in TBI, with a particular emphasis on their impact on outcomes. Relevant articles published within the past decade were prioritized, and a qualitative synthesis of the findings was performed. Results: Behavioral interventions have demonstrated their effectiveness in addressing various aspects of TBI care. They have been instrumental in improving cognitive functions, emotional stability, and adaptive behaviors among TBI patients. However, it is important to acknowledge that challenges still exist, including issues related to clinical heterogeneity and healthcare disparities. Conclusion: The integration of behavioral interventions into standard clinical practice marks a transformative shift in TBI care. This approach holds immense potential for enhancing patient outcomes and elevating the overall quality of life for individuals grappling with the complexities of this condition. This review serves as a clarion call for healthcare practitioners, researchers, and policymakers to recognize the pivotal role of behavioral interventions in TBI care, advocating for their wider adoption to advance the field toward a more holistic and patient-centric approach.

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Section: Lifestyle-based Interventionsmentioning

confidence: 99%