Exercise: shifting fluid and sleep apnoea away

Kline, Christopher E.

doi:10.1183/13993003.00797-2016

Cited by 11 publications

(6 citation statements)

References 28 publications

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“…15 ET reduces the accumulation of fluid in the neck region in patients with OSA. 29,30 The accumulation of rostral fluid in the neck region in patients with OSA causes collapse of the upper airways by reducing air space. 31 Reduction of fluid in the neck contributes to the decrease in AHI and improves sleep quality in patients with OSA.…”

Section: Discussionmentioning

confidence: 99%

Effects of Exercise Training on Left Ventricular Diastolic Function Markers in Patients with Obstructive Sleep Apnea: A Randomized Study

Durante¹,

Ferreira-Silva²,

Goya³

et al. 2022

International Journal of Cardiovascular Sciences

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Background:Exercise training (ET) is an adjunctive treatment for obstructive sleep apnea (OSA) and its consequences. However, the effects of exercise on heart remodeling are unknown in the population with OSA. Objective:We investigated the effect of ET on markers of diastolic function, sleep parameters, and functional capacity in patients with OSA.Methods: Sedentary patients with OSA (apnea-hypopnea index, AHI ≥15 events/hr) were randomly assigned to untrained (n=18) and trained (n=20) strategies. Polysomnography, cardiopulmonary exercise test, and echocardiography were evaluated at the beginning and end of the study. ET consisted of 3 weekly sessions of aerobic exercise, resistance exercises, and flexibility training (72 sessions, completed in 11.65±0.86 months). A twoway analysis of variance (ANOVA) was used, followed by Tukey's post-hoc test. The level of statistical significance was set at p<0.05 for all analyses.Result: Thirty-eight patients were included (AHI:45±29 events/hr, age:52±7 y, body mass index: 30±4 kg/m 2 ). They had similar baseline parameters. ET caused a significant change in OSA severity (AHI:4.5±18 versus -5.7±13 events/ hr; arousal index:1.5±8 versus -6.1±13 events/hr, in untrained and trained groups respectively, p<0.05). The trained patients had an increase in functional capacity after intervention. ET improved isovolumetric relaxation time (IVRT, untrained=6.5±17.3 versus trained=-5.1±17.1 msec, p<0.05). There was a significant correlation between changes in IVRT and arousal index in the trained group (r =-0.54, p<0.05). No difference occurred in the other diastolic function parameters evaluated. Conclusion:ET promotes modest but significant improvement in AHI, functional capacity, and cardiac IVRT, a validated parameter of diastolic function.

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Section: Discussionmentioning

confidence: 99%

Effects of Exercise Training on Left Ventricular Diastolic Function Markers in Patients with Obstructive Sleep Apnea: A Randomized Study

Durante¹,

Ferreira-Silva²,

Goya³

et al. 2022

International Journal of Cardiovascular Sciences

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“…A possible explanation for improving sleep parameters, more specifically those changes in AHI, arousal index, and O 2 desaturation in the exercise-trained group, was due to the fact that ET would attenuate the narrowing or collapse of the upper airways by the redistribution of rostral fluid in the neck, reducing the severity of OSA ( 35 ). Alternatively, the increase in muscle tone of the genioglossus ( 36 ) reduces hypoxia and arousal episodes during sleep even without a significant change in body weight ( 21 , 35 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of exercise training on autonomic modulation and mood symptoms in patients with obstructive sleep apnea

Araujo

Ferreira-Silva

Gara

et al. 2021

Braz J Med Biol Res

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We evaluated the effects of exercise training (ET) on the profile of mood states (POMS), heart rate variability, spontaneous baroreflex sensitivity (BRS), and sleep disturbance severity in patients with obstructive sleep apnea (OSA). Forty-four patients were randomized into 2 groups, 18 patients completed the untrained period and 16 patients completed the exercise training (ET). Beat-to-beat heart rate and blood pressure were simultaneously collected for 5 min at rest. Heart rate variability (RR interval) was assessed in time domain and frequency domain (FFT spectral analysis). BRS was analyzed with the sequence method, and POMS was analyzed across the 6 categories (tension, depression, hostility, vigor, fatigue, and confusion). ET consisted of 3 weekly sessions of aerobic exercise, local strengthening, and stretching exercises (72 sessions, achieved in 40 ± 3.9 weeks). Baseline parameters were similar between groups. The comparisons between groups showed that the changes in apnea-hypopnea index, arousal index, and O 2 desaturation in the exercise group were significantly greater than in the untrained group (Po0.05). The heart rate variability and BRS were significantly higher in the exercise group compared with the untrained group (Po0.05). ET increased peak oxygen uptake (Po0.05) and reduced POMS fatigue (Po0.05). A positive correlation (r=0.60, Po0.02) occurred between changes in the fatigue item and OSA severity. ET improved heart rate variability, BRS, fatigue, and sleep parameters in patients with OSA. These effects were associated with improved sleep parameters, fatigue, and cardiac autonomic modulation, with ET being a possible protective factor against the deleterious effects of hypoxia on these components in patients with OSA.

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“…Uma possível explicação para compreendermos os resultados apresentados em nosso estudo acerca da melhora dos parâmetros do sono, mais especificamente acerca do IAH, e número de despertares, é o fato de que pacientes com AOS apresentam acúmulo de fluído rostral noturno na região do pescoço que reduz o tamanho do lúmen e aumenta o colapso das vias aéreas superiores 110,111,114 . O TF estaria atenuando o estreitamento ou colapso das vias aéreas superiores pela redistribuição do fluído rostral no pescoço, reduzindo a gravidade da AOS 110,111,114 . Segundo este mecanismo, o TF levaria a um menor volume do líquido no pescoço reduzindo a quantidade de hipóxias e despertares durante o sono mesmo sem obter diferença significativa do peso corporal 114,115 .…”

Section: -Discussãounclassified

“…O TF estaria atenuando o estreitamento ou colapso das vias aéreas superiores pela redistribuição do fluído rostral no pescoço, reduzindo a gravidade da AOS 110,111,114 . Segundo este mecanismo, o TF levaria a um menor volume do líquido no pescoço reduzindo a quantidade de hipóxias e despertares durante o sono mesmo sem obter diferença significativa do peso corporal 114,115 .…”

Section: -Discussãounclassified

Efeitos do treinamento físico na modulação autonômica cardíaca e no perfil de humor em pacientes com apneia obstrutiva do sono

Araujo¹

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Agradeço à Deus, pelos meus pais, que sempre prestaram total suporte em minha vida e prinncipalmente de forma incondicional no decorrer da confecção deste trabalho, pelos meus amigos, pela minha saúde e da minha família, por todas as oportunidades surgidas, e toda benção recebida. À Profª Drª Linda Massako Ueno Pardi pela oportunidade de fazer parte de sua equipe, por ter sido essencial na confecção deste trabalho que resultará em grande crescimento de minha carreira. Ao Profº Thiago Goya e Profº Rosyvaldo que acompanharam todo o processo de coleta, em especial ao Profº Thiago Goya por todo o suporte e análise de dados deste trabalho. Ao Profº Dr. Rubens Fazan Junior e equipe do Departamento de Fisiologia da Faculdade de Medicina da Usp de Ribeirão Preto por todo o suporte com o programa usado na análise dos dados. Aos colegas do laboratório e das disciplinas das quais eu frequentei e tive a oportunidade de aprender com todos.

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Exercise: shifting fluid and sleep apnoea away

Cited by 11 publications

References 28 publications

Effects of Exercise Training on Left Ventricular Diastolic Function Markers in Patients with Obstructive Sleep Apnea: A Randomized Study

Effects of Exercise Training on Left Ventricular Diastolic Function Markers in Patients with Obstructive Sleep Apnea: A Randomized Study

Effects of exercise training on autonomic modulation and mood symptoms in patients with obstructive sleep apnea

Efeitos do treinamento físico na modulação autonômica cardíaca e no perfil de humor em pacientes com apneia obstrutiva do sono

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