Exercise training and DNA methylation profile in post-bariatric women: Results from an exploratory study

Nicoletti, Carolina Ferreira; Roschel, Hamilton; Merege-Filho, Carlos; Lima, Alisson Padilha de; Gil, Saulo; Pinhel, Marcela Augusta Souza; Noronha, Natália Yumi; Santo, Marco Aurélio; Jácome, Amalia; Crujeiras, Ana B.; Gualano, Bruno; Nonino, Carla Barbosa

doi:10.3389/fspor.2023.1092050

Cited by 2 publications

(1 citation statement)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, a study that evaluated the effect of combined exercise in epigenetic pro le of women who underwent bariatric surgery also found changes in genes related to in ammatory pathways [9].…”

Section: Introductionmentioning

confidence: 99%

8-week Combined Exercise Protocol Promote Health and Cardiovascular Benefits in Obese Women by Epigenetic Modifications: a Prospective Study

Brandão,

Rodrigues,

Noronha

et al. 2024

Preprint

View full text Add to dashboard Cite

Background: It is known that obesity can be affected by genetic and epigenetic alterations, however little is known about the DNA methylation markers related to health promotion interventions aiming weigh loss. This study explored the effects of an 8-week integrated strength and aerobic training protocol on the DNA methylation patterns in obese women. Methods: 13 women with a BMI of 33±2 kg/m², aged 34±5 years, underwent evaluation of body composition, waist circumference, physical performance (VO2max), and peripheral blood collection for DNA methylation analysis (EPIC Beadchip Illumina) before and after eight weeks of combined physical training intervention (3 times/week, 55 minutes/session, 70-90% of max HR). Results: The intervention yielded noteworthy clinical enhancements, encompassing diminished waist circumference, fat mass, and increased VO2 max (p<0.05). In DNA methylation, we identified 16 Differentially Methylated Regions (DMRs) encompassing 103 CpG sites. Most of these regions were mainly located in promoters’ regions (TSS1500 and TSS200). Among the identified DMRs, 8 exhibited hypomethylation, while the remaining 8 showed hypermethylation after exercise protocol. Enrichment analysis unveiled pathways linked to cardiac, immune, and thermogenic functions. Conclusion: Combined physical training can promote modifications in the DNA methylation profile at CpG sites in genes involved in energy metabolism pathways, increase physical performance, and reduce body fat and waist circumference. Regardless of weight loss, the exercise protocol may promote protection against cardiovascular diseases through epigenetic modifications. Trial registration: ClinicalTrials.gov (NTC 03119350).

show abstract

Section: Introductionmentioning

confidence: 99%

8-week Combined Exercise Protocol Promote Health and Cardiovascular Benefits in Obese Women by Epigenetic Modifications: a Prospective Study

Brandão,

Rodrigues,

Noronha

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

The role of epigenetic modifications in the formation of heterogeneous phenotypes in diabetes mellitus (a literature review)

Zinych,

Shuprovych,

Trofymenko

et al. 2023

Med. perspekt.

View full text Add to dashboard Cite

This review article provides a summary and update on the role of epigenetic mechanisms in predisposition and progression of diabetes, analyzes the data concerning the cause-and-effect relationship between epigenetic changes and the emergence of distinct metabolic phenotypes. Extensive genetic research has enabled the isolation of a group of genes associated with a high risk of developing diabetes. However, numerous data point to the key role of so-called epigenetic modifications in the interaction between genes and the environment, which arise during ontogenesis based on the existing genotype under the influence of external factors. These modifications do not affect the primary DNA sequence, but influence gene expression through chemical modification and alteration of the secondary structure of DNA molecules and chromatin. Epigenetic mechanisms can program pathological phenotypes in subsequent generations. The main molecular mechanisms of epigenetic modifications are DNA methylation, histone and miRNA modification. Changes in the expression of genes that ensure the synthesis of key enzymes and regulatory molecules lead to disruption in the main signaling metabolic pathways. Deregulation of genes responsible for inflammatory, atherosclerotic and other pathological processes, in particular, leads to endothelial dysfunction and development of diabetic complications, such as cardiovascular diseases, diabetic nephropathy, retinopathy, neuropathy. Hyperglycemia, oxidative stress, inflammatory factors are known as mediators in the pathogenesis of type 2 diabetes and its complications. Since epigenetic modifications are reversible, the methylation process can be influenced by exercise, dietary, lifestyle changes and pharmacological agents such as methyl group donors. For example, S-adenosylmethionine, through participation in methylation reactions, can modulate the folate cycle function and production of homocysteine, an endothelium-toxic substance. Thus, the study of molecular modifications in chromatin structure and the features of activation and inhibition of various signaling pathways is a pressing task, the resolution of which will enable a deeper understanding of the pathogenesis of diabetes and the development of approaches to correct metabolic disorders.

show abstract

Exercise training and DNA methylation profile in post-bariatric women: Results from an exploratory study

Cited by 2 publications

References 21 publications

8-week Combined Exercise Protocol Promote Health and Cardiovascular Benefits in Obese Women by Epigenetic Modifications: a Prospective Study

8-week Combined Exercise Protocol Promote Health and Cardiovascular Benefits in Obese Women by Epigenetic Modifications: a Prospective Study

The role of epigenetic modifications in the formation of heterogeneous phenotypes in diabetes mellitus (a literature review)

Contact Info

Product

Resources

About