Exercise Training for Women With Fibromyalgia Syndrome

Silva, Lais Carneiro; Dittgen, Michelle; Meroni, Roberto; Sanchez-Romero, Eleuterio A.; Rossettini, Giacomo; Villafañe, Jorge Hugo; Corbellini, Camilo

doi:10.1097/tgr.0000000000000435

Topics in Geriatric Rehabilitation

2024

DOI: 10.1097/tgr.0000000000000435

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Exercise Training for Women With Fibromyalgia Syndrome

Lais Carneiro Silva,

Michelle Dittgen,

Roberto Meroni

et al.

Abstract: Background: To identify in the literature the exercise training therapies for females with fibromyalgia that may improve pain management and quality of life (QOL). Methods: A literature search was conducted in MEDLINE and PEDro databases for human studies up to June 2021. We considered studies if they investigated exercise therapies and their impact on pain, QOL, physical function, and mental health in female patients with fibromyalgia. … Show more

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Cited by 3 publications

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The Association between Pressure Pain Thresholds, Conditioned Pain Modulation, Clinical Status, and Sleep Quality in Fibromyalgia Patients: A Clinical Trial Secondary Analysis

González-Álvarez,

Riquelme-Aguado,

Arribas-Romano

et al. 2024

JCM

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Background: Fibromyalgia (FM) is a complex multidimensional disorder primarily characterized by chronic widespread pain, significantly affecting patients’ quality of life. FM is associated with some clinical signs found with quantitative sensory testing (QST), sleep disturbance, or psychological problems. This study aims to explore the associations between pressure pain thresholds (PPTs), conditioned pain modulation (CPM), clinical status, and sleep quality in FM patients, offering insights for better clinical management and assessment tools. Methods: This secondary analysis utilized data from a clinical trial involving 129 FM patients. Various assessments, including the Fibromyalgia Impact Questionnaire (FIQ), Pain Catastrophizing Scale (PCS), State-Trait Anxiety Inventory (STAI), and Jenkins Sleep Scale (JSS), were employed to evaluate the clinical and psychological status and sleep quality. PPTs and CPM were measured to understand their relationship with clinical parameters. Results: Our findings revealed that PPTs and CPM are not significantly associated with the clinical status or sleep quality of FM patients. Instead, pain catastrophizing and anxiety state showed a stronger correlation with the impact of fibromyalgia and sleep disturbances. These results highlight the importance of psychological and cognitive factors in managing FM. Conclusions: The study suggests that while PPTs and CPM may not be reliable biomarkers for clinical status in FM, the use of comprehensive assessments including FIQ, PCS, STAI, and JSS can provide a more accurate evaluation of patients’ condition. These tools are cost-effective, can be self-administered, and facilitate a holistic approach to FM management, emphasizing the need for personalized treatment plans.

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The Association between Pressure Pain Thresholds, Conditioned Pain Modulation, Clinical Status, and Sleep Quality in Fibromyalgia Patients: A Clinical Trial Secondary Analysis

González-Álvarez,

Riquelme-Aguado,

Arribas-Romano

et al. 2024

JCM

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Electroacupuncture Regulates Cannabinoid Receptor 1 Expression in a Mouse Fibromyalgia Model: Pharmacological and Chemogenetic Modulation

Yeh,

Hsu,

Lin

et al. 2024

Life

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Fibromyalgia is a chronic illness usually accompanied by long-lasting, general pain throughout the body, often accompanied by anxiety, depression, fatigue, and sleep disruption. Meanwhile, doctors and scientists have not entirely discovered detailed mechanisms; patients always have an exaggerated sensation to pervasive pain without satisfied medical service. Given the lack of knowledge on its underlying mechanism, current treatments aim to provide pain and/or symptom relief. The present study aimed to clarify the role of cannabinoid receptor 1 (CB1) signaling in a mouse fibromyalgia pain model. To develop the mouse fibromyalgia model, mice were subjected to intermittent cold stress (ICS). Our results indicated that mechanical (2.09 ± 0.09 g) and thermal hyperalgesia (4.77 ± 0.29 s), which were evaluated by von Frey and Hargraves’ tests, were induced by ICS, suggesting successful modeling. The hurting replies were then provoked by electroacupuncture (EA) but not for sham EA mice. Further, in a Western blot analysis, we found significantly decreased CB1 protein levels in the thalamus, somatosensory cortex, and anterior cingulate cortex. In addition, the levels of pain-related protein kinases and transcription factor were increased. Treatment with EA reliably increased CB1 expression in various brain regions sequentially alleviated by nociceptive mediators. Furthermore, the administration of a CB1 agonist significantly attenuated fibromyalgia pain, reversed EA analgesia by the CB1 antagonist, and further reversed the chemogenetic inhibition of SSC. Our innovative findings evidence the role of CB1 signaling in the interaction of EA and fibromyalgia, suggesting its potential for clinical trials and as a treatment target.

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Exercise Intervention in Women with Fibromyalgia and Its Influence on Pain, Psychological Variables, and Disability: An Observational Study

González-Álvarez,

Riquelme-Aguado,

Rossettini

et al. 2024

Life

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(1) Background: Fibromyalgia syndrome (FM) is a specific condition within the spectrum of musculoskeletal pain disorders, with an estimated global prevalence of 2%. Physical exercise has shown promise in modulating pain and improving physical function without the drawbacks of pharmacotherapy. This study aims to examine the effects of a 6-week telerehabilitation combined exercise program—including mobility, strength, and high-intensity exercises—on pain, psychological variables, and disability in women with fibromyalgia. (2) Methods: In this observational study involving 53 FM patients, the outcomes measured were the pressure pain threshold (PPT), the conditioned pain modulation (CPM) paradigm, levels of pain on the measurement day and the average of the last week (using NRS) the impact of the fibromyalgia (using Fibromyalgia Impact Questionnaire (FIQ), and anxiety (using the Spanish version of the State–Trait Anxiety Inventory—STAI). (3) Results: Statistically significant changes were observed in the intervention group in PPT, CPM, NRS, and FIQ. (4) Conclusions: A six-week telerehabilitation therapeutic exercise intervention consisting of two scheduled exercise sessions per week lasting approximately 45 min each is associated with reduced pain levels, enhanced pain inhibitory pathways, and a decreased impact of fibromyalgia compared to patients who do not adopt a more active lifestyle.

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Exercise Training for Women With Fibromyalgia Syndrome

Cited by 3 publications

References 33 publications

The Association between Pressure Pain Thresholds, Conditioned Pain Modulation, Clinical Status, and Sleep Quality in Fibromyalgia Patients: A Clinical Trial Secondary Analysis

The Association between Pressure Pain Thresholds, Conditioned Pain Modulation, Clinical Status, and Sleep Quality in Fibromyalgia Patients: A Clinical Trial Secondary Analysis

Electroacupuncture Regulates Cannabinoid Receptor 1 Expression in a Mouse Fibromyalgia Model: Pharmacological and Chemogenetic Modulation

Exercise Intervention in Women with Fibromyalgia and Its Influence on Pain, Psychological Variables, and Disability: An Observational Study

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