Exercise Training Normalizes Timing of Left Ventricular Untwist Rate, but Not Peak Untwist Rate, in Individuals with Type 2 Diabetes and Diastolic Dysfunction: A Pilot Study

Effect of High Intensity Interval Training on Cardiac Function in Children with Obesity: A Randomised Controlled Trial

“…Still, our findings suggest that HIIT was a more potent stimulus for improving global cardiac function and myocardial contractility than MICT. This is consistent with evidence from adults with chronic disease 18,19,[30][31][32] and animal models [33][34][35] . Wisloff et al (2007) showed that twelve weeks of HIIT was superior to MICT and standard care for improving EF (10pp or 35% increase, P<0.020) in patients with stable post infarction heart failure 18 .…”

Comparison of speckle-tracking echocardiography with invasive hemodynamics for the detection of characteristic cardiac dysfunction in type-1 and type-2 diabetic rat models

“…Strain measurements may notably overcome the aforementioned limitations by reflecting intrinsic myocardial function and also by being a semi-automated method. Sensitivity of strain measures were proved in numerous pathological conditions in human and also in animal experiments [ 18 , 19 ] including diabetic cardiomyopathy [ 4 , 20 – 23 ]. Furthermore, in our recent work, we were able to show correlations between STE and PV analysis derived measures in a rat model of increased cardiac contractility [ 9 ].…”

Correlation between myocardial deformation on three‐dimensional speckle tracking echocardiography and cardiopulmonary exercise testing

“…Diastolic dysfunction has been attributed to a prolonged untwisting phase and has a significant influence on LV early diastolic filling . Because the peak of the untwisting rate in healthy individuals occurs at 10%–20% of the diastolic phase, a significant delay of the peak untwisting rate can be observed in patients with diastolic dysfunction . Thus, the peak point of the untwisting phase occurs before 25% of the total untwisting duration, but the peak point in the delayed untwisting phase may occur later in patients with diastolic dysfunction.…”

“…14,15 Because the peak of the untwisting rate in healthy individuals occurs at 10%-20% of the diastolic phase, a significant delay of the peak untwisting rate can be observed in patients with diastolic dysfunction. 16,17 Thus, the peak point of the E/e = ratio of early diastolic peak velocity to the early diastolic peak velocity of the mitral annulus; GLS = global longitudinal systolic peak strain; 25% Untwist = the amount of untwisting at 25% of the untwisting duration. E/e = ratio of early diastolic peak velocity to the early diastolic peak velocity of the mitral annulus; 25% Untwist = the amount of untwisting at 25% of the untwisting duration.…”