“…10 Several case reports in literature have described severe intimal thickening consisting predominantly of fibrous tissue without extracellular deposits. 22,23 Nonatherosclerotic causes for nonostial stenosis reported in literature include extrinsic compression of the left main artery by tumor, aneurysm, patent ductus arteriosus, 24 spasm, 25 iatrogenic, 26 and type II hyperlipoproteinemia. 4 In the present study, we found that isolated and significant LMCA disease occurs frequently in association with commonly recognized risk factors for atherosclerotic coronary artery disease.…”