Exfoliation and in situ functionalization of MoS2 nanosheets for MRI-guided combined low-temperature photothermal therapy and chemotherapy

Cai, Lulu; Dong, Lei; Sha, Xuan; Zhang, Shuai; Liu, Siwen; Song, Xiaoxi; Zhao, Mingming; Wang, Qi; Xu, Kai; Li, Jingjing

doi:10.1016/j.matdes.2021.110020

Cited by 19 publications

(9 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the biocompatibility of MM@Lips-SHP1i was also evaluated by hemolysis assay [ 22 ]. Briefly, fresh mouse blood samples were collected and centrifuged to separate RBCs.…”

Section: Methodsmentioning

confidence: 99%

Pro-efferocytic macrophage membrane biomimetic nanoparticles for the synergistic treatment of atherosclerosis via competition effect

et al. 2022

Self Cite

View full text Add to dashboard Cite

Macrophages participate in many links in the pathological process of atherosclerosis (AS) and the regulation of influence of macrophages at the molecular level might be a new avenue for AS treatment. For this aim, the macrophage membrane biomimetic nanoparticles, derived from macrophage membrane coated SHP1i-loaded liposome NPs (MM@Lips-SHP1i) was designed. Due to the reservation of intrinsic membrane proteins and function from macrophages, the biomimic nanoparticles could effectively evade clearance by the immune system, prolong blood circulation time and actively tend and aggregate to atherosclerotic plaques. More importantly, in the plaque area, MM@Lips-SHP1i nanoparticles could compete with macrophages in vivo to bind with oxidized low-density lipoprotein (oxLDL) and lipopolysaccharide (LPS), reduce uptake of new lipids by macrophages, reduce foam cell formation, and inhibit the expression of pro-inflammatory cytokines. In addition, small molecule inhibitor of SHP-1, the downstream effector molecule of CD47 loaded in macrophage membrane biomimetic nanoparticles could interrupt CD47-SIRPα signal transduction in monocytes and macrophages, thereby enhancing the efferocytosis of macrophages, inhibiting the progression of plaque, achieving synergistic treatment of atherosclerosis. This work focuses on the key process in the formation of AS, macrophage foaming and chronic inflammation, and is based on the fact that macrophage membrane biomimetic nanoparticles can preserve the key surface proteins of macrophages closely related to the formation of AS, providing a new avenue to inhibit the progression of AS by utilizing the biological characteristics of macrophage membrane in macrophage membrane biomimetic nanoparticles.

show abstract

“…In addition, the biocompatibility of MM@Lips-SHP1i was also evaluated by hemolysis assay [ 22 ]. Briefly, fresh mouse blood samples were collected and centrifuged to separate RBCs.…”

Section: Methodsmentioning

confidence: 99%

Pro-efferocytic macrophage membrane biomimetic nanoparticles for the synergistic treatment of atherosclerosis via competition effect

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…[121][122][123][124] Among these Mo-NMs, MoS 2 nanosheets are the most widely used templates to further grow other nanomaterials. [66,73,[78][79][80][81][125][126][127][128][129][130][131][132][133][134][135] For example, they can be used to deposit noble metals, such as Au nanoparticles and nanorods, to prepare MoS 2 -templated Au nanocomposites. [78][79][80]82] Moreover, MoS 2 nanosheets can be used to grow metal oxide nanoparticles, such as HfO 2 , [125] TaO 2 , [126] Gd 2 O 3 [128] SiO 2 , [129] Cu 2 O, [130] CeO 2 , [131] ZnO, [133] Fe 3 O 4 , [134] and FeO, [136] on their surface to obtain MoS 2 -templated metal oxide nanocomposites.…”

Section: Molybdenum-based Nanocompositesmentioning

confidence: 99%

“…[66,73,[78][79][80][81][125][126][127][128][129][130][131][132][133][134][135] For example, they can be used to deposit noble metals, such as Au nanoparticles and nanorods, to prepare MoS 2 -templated Au nanocomposites. [78][79][80]82] Moreover, MoS 2 nanosheets can be used to grow metal oxide nanoparticles, such as HfO 2 , [125] TaO 2 , [126] Gd 2 O 3 [128] SiO 2 , [129] Cu 2 O, [130] CeO 2 , [131] ZnO, [133] Fe 3 O 4 , [134] and FeO, [136] on their surface to obtain MoS 2 -templated metal oxide nanocomposites. Other kinds of metal chalcogenides, such as MoSe 2 , [84] Bi 2 S 3 , [132] CuS, [134] and Cu 1.8 S, [135] can also hybridize with MoS 2 to form MoS 2 -based metal chalcogenide nanocomposites.…”

Section: Molybdenum-based Nanocompositesmentioning

confidence: 99%

Molybdenum‐Based Nanomaterials for Photothermal Cancer Therapy

Zhou

et al. 2022

Advanced NanoBiomed Research

View full text Add to dashboard Cite

Figure 2. Preparation of Mo-based NMs via ultrasound-assisted liquid-phase exfoliation strategy. A) Monolayer molybdenum dichalcogenides (MoS 2 andMoSe 2 ) nanosheets possess superior biomedical stability and high photothermal conversion effect. Reproduced with permission. [147] Copyright 2018, American Chemical Society. B) Single layer of MoSe 2 nanosheets as a novel PAI/PTT theranostic nanoagent. Reproduced with permission. [143] Copyright 2018, Royal Society of Chemistry. C) Hydrophobic MoSe 2 nanosheets as a photothermal-chemotherapeutic agent. Reproduced with permission. [149] Copyright 2020, Royal Society of Chemistry. D) Oxygen-deficient α-MoO 3Àx nanoflakes exhibit high biocompatibility and physiological stability. Reproduced with permission. [150] Copyright 2018, Wiley-VCH.

show abstract

“…In addition, On this basis, the tumor-targeting ligand HA was loaded into this nanosystem, and the tumor was thermally ablated under 808 nm laser irradiation. 258 BP is also one of the most popular 2D nanomaterials that display prominent physicochemical properties, biocompatibility, and biodegradability; therefore, it is widely utilized in PTT development. 259−261 BP has a bilayer structure in the zigzag orientation.…”

Section: Recently Developed Nanomaterials Formentioning

confidence: 99%

“…In addition, Cai et al used bovine serum albumin template gadolinium oxide (BSA-Gd 2 O 3 ) NPs as a stripping agent and a T 1 -weighted MRI contrast agent to realize the stripping and in situ functionalization of single-layer MoS 2 . On this basis, the tumor-targeting ligand HA was loaded into this nanosystem, and the tumor was thermally ablated under 808 nm laser irradiation …”

Section: Recently Developed Nanomaterials For Pttmentioning

confidence: 99%

Review of Functionalized Nanomaterials for Photothermal Therapy of Cancers

Bian

Wang

Pan

et al. 2021

ACS Appl. Nano Mater.

119

View full text Add to dashboard Cite

Photothermal therapy (PTT) is recognized as a promising approach for cancer theranostics via the nonradiative conversion of light into heat energy. PTT treatment is able to reduce the adverse side effects of traditional chemotherapy. Some nanomaterials functionalized with unique physical and chemical properties have been integrated with multiple imaging modalities and a therapeutic function for applications. In the past decade, various nanomaterials for PTT applications have been reviewed, but a comprehensive survey of all classes of photothermal nanomaterials developed in recent years has not been done. A comprehensive discussion of PTT mechanisms using different nanomaterials and their application in combination therapy is useful for providing insights for PTT material development for disease treatment in the future. In this review, the recent advancement of functionalized nanomaterials for PTT and the excellence of PTT combined therapies in the field of anticancer are discussed. The momentous property of nanomaterials tailored for advancing the noninvasive therapeutic approach of PTT is also highlighted. Because a great deal of PTT nanomaterials have been developed in the past decades and reviewed in recent years, in this review, we only include the latest results reported in the past 5 years for discussion and comparison.

show abstract

Exfoliation and in situ functionalization of MoS2 nanosheets for MRI-guided combined low-temperature photothermal therapy and chemotherapy

Cited by 19 publications

References 52 publications

Pro-efferocytic macrophage membrane biomimetic nanoparticles for the synergistic treatment of atherosclerosis via competition effect

Pro-efferocytic macrophage membrane biomimetic nanoparticles for the synergistic treatment of atherosclerosis via competition effect

Molybdenum‐Based Nanomaterials for Photothermal Cancer Therapy

Review of Functionalized Nanomaterials for Photothermal Therapy of Cancers

Contact Info

Product

Resources

About