Exhaled nitric oxide as a diagnostic test for asthma in rhinitic patients with asthmatic symptoms

Abstract

Measuring FE(NO) may be useful for the screening of rhinitic patients with asthma-like symptoms.

Measurement of exhaled nitric oxide concentration in asthma: a systematic review and economic evaluation of NIOX MINO, NIOX VERO and NObreath

“…Adults, adults plus adolescents, all age groups and unspecified age groups ), adults plus adolescents (three studies, four citations [82][83][84][85] ), all age groups (three studies, three citations [86][87][88] or an unspecified age range (three studies, three citations 89,90,92 ). Table 21 summarises the characteristics of the studies and provides a brief description explaining their relevance to the decision problem (note: Schneider et al 71,72 appears twice in this table as this study reported two differently defined populations).…”

“…l Nine studies 54,[69][70][71][72][82][83][84]86,87,90 recruited patients with symptoms of asthma who were broadly equivalent to patients entering the UK pathway at position A (see Figure 8). Of these, six 69,71,72,[82][83][84]86,87 were considered to be of most relevance to the decision problem, although the studies had not necessarily been conducted in the UK.…”

“…Of these, six 69,71,72,[82][83][84]86,87 were considered to be of most relevance to the decision problem, although the studies had not necessarily been conducted in the UK. l Nine studies [73][74][75][76][77]81,85,88,89,91 recruited patients who could be considered 'difficult to diagnose' and are located at other points along the diagnostic pathway.…”

“…These studies are Schneider et al, 69 Schneider et al, 71,72 Schleich et al, 77 Prieto et al, 76 El Halawani et al, 78 Hsu et al, 73 Hahn et al, 74 Pedrosa et al, 85 Heffler et al, 82 Smith et al 83 (de la Barra et al 84 reports additional analyses to Smith et al 83 ) Smith et al, 86 Bobolea et al, 88 Cordeiro et al 87 and Katsoulis et al…”

“…Quality assessment of studies relevant to the decision problem Sixteen studies (18 citations 69,[71][72][73][74][76][77][78][80][81][82][83][84][85][86][87][88]92 ) exploring FeNO measurement for the diagnosis of asthma in adults were assessed for quality according to QUADAS-2 criteria for diagnostic accuracy studies. 38 Although based on the same data as the study by Smith et al, 83 the study by de la Barra et al 84 was assessed separately as the analysis was different.…”