Exhaled nitric oxide in asthma: From bench to bedside

Bates, Christopher A.; Silkoff, Philip E.

doi:10.1067/mai.2003.103

Cited by 94 publications

(75 citation statements)

References 51 publications

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“…Thus, factors affecting FeNO in Asian children are generally similar to those reported in Caucasian children [6-8, 10, 13]. Although the mechanism for the age dependence of FeNO is largely unknown, having the same fixed expiratory flow in all ages is a possible reason [4]. With increasing height accompanying ageing, the total airway mucosal surface area available for NO diffusion will increase, which will lead to higher FeNO levels using the same exhalation flow rate [27,28].…”

Section: Exhaled Biomarkers T-c Yao Et Alsupporting

confidence: 53%

“…here is growing interest in the potential application of measurement of the exhaled nitric oxide fraction (FeNO) in the diagnosis and management of asthma from research to clinical practice [1][2][3][4][5]. More work is required to determine reference values for appropriate interpretation [1,2] and, although there have been a few studies presenting reference values of FeNO for children, these have focused on Caucasian populations [6][7][8].…”

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confidence: 99%

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Reference values of exhaled nitric oxide in healthy Asian children aged 5 to 18 years

Yao

Wi²,

Ls³

et al. 2011

Eur Respir J

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This study was undertaken to establish reference values of exhaled nitric oxide fraction (FeNO) and its determinants in healthy Asian children.693 healthy Asian children aged 5-18 yrs were assessed using a single-breath online FeNO measurement (exhaled flow 50 mL?s -1 ), questionnaires, anthropometric measurements, spirometry and total and specific immunoglobulin (Ig) E.Geometric mean FeNO and the upper 95% CI were 13.7 ppb and 49.7 ppb, respectively, for healthy children, and 11.2 ppb and 30.2 ppb, respectively, for those without allergic sensitisation. FeNO was positively associated with age, allergic sensitisation, total IgE, ambient nitric oxide, measurement in the afternoon, and drinking water within 1 h before testing, and was negatively associated with weight. In healthy children without allergic sensitisation, age was the single best explanatory variable. The FeNO predicted values were 1-2 ppb higher in Asian than in Caucasian children in earlier studies, while the upper 95% CI were 9-10 ppb higher.In conclusion, the upper limits of normal FeNO in Asian children depend on age, from 21 ppb in young children to 39 ppb in adolescents. Ethnicity, age, allergic sensitisation, total IgE, ambient nitric oxide, time of testing, drinking water and weight are important determinants.

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Section: Exhaled Biomarkers T-c Yao Et Alsupporting

confidence: 53%

mentioning

confidence: 99%

Reference values of exhaled nitric oxide in healthy Asian children aged 5 to 18 years

Yao

Wi²,

Ls³

et al. 2011

Eur Respir J

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“…Previous reports suggest that determinants of Fe NO levels are complex; although they often reflect eosinophilic airway inflammation, they can also reflect airway metabolism of superoxide, arginine, S-nitrosoglutathione, and other compounds. 19,[27][28][29][30][31][32][33] Our data suggest that subjects with severe asthma do not uniformly fall into the high Fe NO -atopic phenotype; further, that clinical interpretation of Fe NO levels may be complicated in severe asthma.…”

Section: Discussionmentioning

confidence: 95%

Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program

Moore¹,

Bleecker²,

Curran‐Everett

et al. 2007

Journal of Allergy and Clinical Immunology

846

782

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“…149,150 (2) In contrast, the substance of interest for the detection of asthma is an inorganic gas, namely, nitric oxide. [151][152][153] By means of an electronic nose, patients with asthma can be clearly discriminated from the control group, whereas the accuracy of classification of severity is less reliable. 154 Recently, a hand-held device was developed by Aerocrine, the NIOX MINO, which is able to determine the NO concentration in exhaled breath accurately.…”

Section: Disease Diagnosismentioning

confidence: 99%