2024
DOI: 10.1101/2024.03.28.587307
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Exhaustion profile on classical monocytes after LPS stimulation in patients with Crohn’s disease

Lucas Pires Garcia Oliveira,
Rafaela Gomes Xavier,
Claudia Concer Viero Nora
et al.

Abstract: Crohn's disease is an inflammatory bowel disease that induces diarrhea, abdominal pain, weight loss, and even susceptibility to developing tumors. The immune system is pivotal in the gastrointestinal tract, promoting tolerance against commensal antigens and food. However, Crohn's disease manifests by a breakdown in the mechanism of immune tolerance and the consequent development of exacerbated chronic inflammatory responses. The involvement of the immune system is pivotal in Crohn's disease, with a wide range … Show more

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