Existe-t-il une relation entre les habitudes alimentaires en Tunisie et le cancer colorectal ? Éléments de réponse à partir d’un échantillon de population

Kassab, Asma; Landolsi, Sondess; Miled, A.; Ahmed, Slim Ben; Gharbi, Olfa

doi:10.1016/j.immbio.2013.05.003

Cited by 5 publications

(6 citation statements)

References 25 publications

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“…As a public health problem worldwide and in Tunisia, CRC incidence increased over the past 20 years [3,4]. In Tunisia, colorectal carcinoma is considered to be the most frequent digestive cancer [5,6].…”

Section: Introductionmentioning

confidence: 99%

“…The 2018 Global Cancer Statistics ranked CRC as the second leading cause of cancerrelated morbidity, with an estimated 881,000 cancer deaths worldwide and nearly 1.8 million new diagnosed cases each year[1,5,6].It has been widely established that the KRAS mutation pattern has a significant impact on the orientation of anticancer therapy. In this context, tumors harboring exon KRAS mutations (codons 12 and 13) do not benefit from EGFR targeted therapies.…”

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confidence: 99%

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Clinicopathological characteristics and mutational profile of KRAS and NRAS in Tunisian patients with sporadic colorectal cancer

et al. 2021

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Background/aim: Colorectal cancer (CRC) is a major public health problem worldwide and in Tunisia due to its increasing incidence. KRAS and NRAS mutations have become a pivotal part of CRC diagnosis, given their association to treatment resistance with anti-epidermal growth factor receptor (EGFR) monoclonal antibodies. We aim to screen for mutations in KRAS and NRAS genes in Tunisian patients with CRC and to explore their correlations with clinicopathological features. Materials and methods: AmoyDx KRAS and NRAS mutation real-time PCR kits were used to screen for mutations in KRAS (exon 2) and NRAS (exons 2, 3 and 4) in 96 CRC tumors. Results: KRAS exon 2 mutations were found in 41.7% (40/96) of the patients. Codon 12 most abundant mutations were G12D and G12V followed by G12A, while G13D is the predominant mutation in codon 13. KRAS exon 2 mutations were associated with older patients (p = 0.029), left-sided tumors (p = 0.037) and greater differentiation (p = 0.044). The prevalence rate of NRAS mutations was 7.3%, mostly in exon 2. These mutations were associated with early stages (p = 0.039) and the absence of lymph node metastasis (p = 0.045). Conclusion: It can be inferred from this study that Tunisian CRC patients have a similar frequency of KRAS and NRAS mutations compared to those observed in other populations. Consequently, screening for KRAS and NRAS mutation is crucial to orientate the therapies and the selection of an appropriate candidate, avoiding patients' unnecessary toxicity and costs.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Clinicopathological characteristics and mutational profile of KRAS and NRAS in Tunisian patients with sporadic colorectal cancer

et al. 2021

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“…In Tunisia, colorectal cancer occupies the first rank of digestive cancers; there has been an increase in the incidence in recent years [33].…”

Section: Localization Of Digestive Cancer By Frequencymentioning

confidence: 99%

Survival Study over 5 Years of Digestive Cancers in Tlemcen Province during 2011-2017

Abdrebbi¹,

Meguenni²

2020

JHS

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In the world, digestive cancers represent a major public health problem by their frequency and severity. Digestive tract cancers are very common malignant tumors worldwide and are an important cause of cancer-related death. The objective of our study was to determinate the survival of digestive cancers in the province of Tlemcen over a period of 5 years. This is a prognostic historical-prospective study with an exhaustive collection data, which consists of studying the 5-year survival of digestive cancers in the province of Tlemcen, of all patients with digestive cancers whatever the stage, diagnosed between 2011 and 2012 and histologically confirmed in subjects residing in the province of Tlemcen at the moment of diagnosis. The subjects of our study were identified from the cancer registry of Tlemcen. In total, 408 cases of digestive cancers were diagnosed over 2 years in Tlemcen province. Most digestive cancers were characterized by a predominance of men except for cancer of the liver, gallbladder and bile ducts but whatever the sex, these cancers occur mainly in subjects whose age is greater than or equal to 45 years. Topographically, for both sexes combined, the colorectum followed by the stomach were the organs most affected by digestive cancers. Histopathologically, a predominance of adenocarcinoma has been noted. The 5-year global survival rate of all digestive cancers was 55.4%, depending on the localization; colorectal cancer, small bowel cancer, gallbladder and bile ducts cancer, stomach and esophagus cancers are cancers of intermediate prognosis whose survival in 5 years is between 40% and 80%. Liver cancer and pancreatic cancer remain poor prognosis cancers with 5-year survival rates of 23.08% and 33.3% respectively. The survival of digestive cancers must be improved by adequate care and surveillance of patients. The prevention of colorectal cancers which occupy the first place among the digestive cancers is based essentially on the knowledge of the risk factors and the screening allowing the improvement of the survival rate. The registry of cancer remains a fundamental tool of any cancer control program; it constitutes a starting source for the analysis of survival.

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“…The incidence of CRC is about three times higher in developed countries than in developing countries (Bray et al, 2018). In Tunisia, colorectal cancer ranks first among digestive cancers (Kassab et al, 2013). Calculation of incidence is difficult due to the lack of a national cancer registry.…”

Section: Introductionmentioning

confidence: 99%

“…Calculation of incidence is difficult due to the lack of a national cancer registry. However, the country has three regional registers: North, Center and South (Kassab et al, 2013). Risk factors studies established that CRC is a complex multifactorial disease implicating genetic factors, environmental factors, inflammatory bowel diseases and also the intestinal microbiota.…”

Section: Introductionmentioning

confidence: 99%

Association of CCR5Δ32 Deletion and Human Cytomegalovirus Infection With Colorectal Cancer in Tunisia

et al. 2021

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Background and objectives: Human cytomegalovirus (HCMV) and genetic polymorphisms of the chemokine receptor 5 have been suggested as factors associated with the progression of colorectal cancer (CRC). The aim of the study was to evaluate the associations of both CCR5Δ32 genetic deletion and/or HCMV virus infection with CRC in Tunisia. Materials and methods: The association between HCMV and CRC was validated by Nested PCR technology performed for HCMV and HCMV-specific serum IgG and IgM antibodies were investigated by enzyme-linked immunosorbent assay. Experiments were carried out on 40 tumor and 35 peri-tumor tissues, 100 blood from CRC patients and on 140 blood samples from healthy subjects and finaly serum samples of 80 patients with CRC and 100 healthy individuals. A conventional PCR has been optimized for the detection of CCR5Δ32 in100 CRC patients and 100 healthy subjects. Results: Our results show that HCMV is significantly active in 93% of patients compared to 60% in controls (p < 0.0001, OR = 8.85, 95% CI: 3.82 -20.50). Compared to the healthy controls, the titers of IgG and IgM antiCMV antibodies in CRC patients were significantly higher than in healthy subjects (p value < 0,0001 for IgG and IgM). Statistical analysis revealed a lack of association between CCR5Δ32 mutation and colorectal cancer (p = 0.788, OR = 1.265, 95% CI: 0.228-7.011). Conclusion: our data confirmed that the HCMV infection was related to the development of CRC and that CRC cells may be infected more favorably by HCMV. Given the importance of the CCR5 in inflammation and therefore CRC progression, further studies still needed to evaluate CCR5 role as a potential candidate gene for CRC susceptibility under other polymorphisms.

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Existe-t-il une relation entre les habitudes alimentaires en Tunisie et le cancer colorectal ? Éléments de réponse à partir d’un échantillon de population

Cited by 5 publications

References 25 publications

Clinicopathological characteristics and mutational profile of KRAS and NRAS in Tunisian patients with sporadic colorectal cancer

Clinicopathological characteristics and mutational profile of KRAS and NRAS in Tunisian patients with sporadic colorectal cancer

Survival Study over 5 Years of Digestive Cancers in Tlemcen Province during 2011-2017

Association of CCR5Δ32 Deletion and Human Cytomegalovirus Infection With Colorectal Cancer in Tunisia

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