Exogenous Bioactive Peptides Have a Potential Therapeutic Role in Delaying Aging in Rodent Models

Abstract

In recent years, some exogenous bioactive peptides have been shown to have promising anti-aging effects. These exogenous peptides may have a mechanism similar to endogenous peptides, and some can even regulate the release of endogenous active peptides and play a synergistic role with endogenous active peptides. Most aging studies use rodents that are easy to maintain in the laboratory and have relatively homogenous genotypes. Moreover, many of the anti-aging studies using bioactive peptides in rodent models only focus on the activity of single endogenous or exogenous active peptides, while the regulatory effects of exogenous active peptides on endogenous active peptides remain largely under-investigated. Furthermore, the anti-aging activity studies only focus on the effects of these bioactive peptides in individual organs or systems. However, the pathological changes of one organ can usually lead to multi-organ complications. Some anti-aging bioactive peptides could be used for rescuing the multi-organ damage associated with aging. In this paper, we review recent reports on the anti-aging effects of bioactive peptides in rodents and summarize the mechanism of action for these peptides, as well as discuss the regulation of exogenous active peptides on endogenous active peptides.

Preparation, Isolation and Antioxidant Function of Peptides from a New Resource of Rumexpatientia L. ×Rumextianshanicus A. Los

“…Currently, only the ROS, MDA, and antioxidant enzyme activities of the two peptides are measured, while the cellular antioxidant mechanism and pathway exploration are not involved. Meanwhile, animal models are able to mimic human physiology and pathology, as well as long-term safety and potential side effects [52]. The final clinical studies are a crucial stage in assessing the genuine effectiveness and safety of peptides in humans, which can objectively evaluate the antioxidant effects of peptides in humans and whether they can improve the symptoms of related diseases [53].…”

Scoping Pleiotropy of CK2 in Musculoskeletal Disorders for a Novel Targeting Approach

“…Several studies prove that interfering peptides alter cellular processes [155,[164][165][166]. Peptides can be produced in several ways, the simplest being procuring naturally occurring peptides [167]. Another method is to develop large numbers of peptides synthetically and then screen them to evaluate their therapeutic potential.…”

Current and promising methods of idiopathic male infertility treatment

“…Активность пептидов основана на их аминокислотном составе и последовательности, они проявляют свои свойства только высвобождаясь из белка-предшественника, в котором они зашифрованы. Такие экзогенные пептиды могут иметь механизм, сходный с эндогенными пептидами, а некоторые из них могут даже регулировать высвобождение эндогенных активных пептидов и играть синергетическую роль [32].…”