Exogenous Factors and Psoriasis

Abstract

Psoriasis is a chronic relapsing disease characterized by variable clinical features. Several factors may exacerbate its manifestations, or even trigger the disease, such as traumatic injury to the skin, physical and psychological stress, cold weather, excessive alcohol intake, and drugs such as lithium and beta-blockers. We describe the most common features of psoriasis and the exogenous factors that may induce, trigger or exacerbate the disease.

Psychiatric morbidity in psoriasis: a study in Himachal Pradesh, India

“…2 Very high rates of stressful life events, ranging from 43 to 68%, have been reported to be preceding the onset of the illness in various studies. 3,4 The data on prevalence of psychiatric morbidity in psoriasis among patients of the psoriasis varies from 26.25% to 95% in previous studies done abroad. 5 Data on Indian patients is limited as only a few studies have been done.…”

645 Imiquimod has strain-dependent effects in mice and does not uniquely model human psoriasis

“…Considering the additional influence of environmental factors [78], it is tempting to argue that studies focused exclusively on genetically homogenous inbred mice, despite all their advantages, can never succeed in fully replicating human diseases and their complexity [79]. An advantage of IMQ, however, is its flexibility and convenience as an experimental approach, which in this study allowed us to demonstrate strain-and sex-dependent effects.…”

The Meaning of Coping With Psoriasis: A Phenomenological Study

“…In this disease, skin cells proliferate rapidly and create a bad appearance for the patient (2). The main cause of psoriasis disease is still unclear and there is no certain cure (3). Global outbreak of this disease has been reported as 1 to 3% (4), and is less than 1% in Iran (5).…”