Exogenous obestatin affects pancreatic enzyme secretion in rat through two opposite mechanisms, direct inhibition and vagally-mediated stimulation

Kapica, M.; Puzio, Iwona; Kato, Ikuo; Kuwahara, Atsukazu; Zabielski, R.; Antushevich, Hanna

doi:10.22358/jafs/89734/2018

Cited by 5 publications

(7 citation statements)

References 30 publications

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“…The pancreatic FA profile reflected FA composition and specific peptide contents in the test diets. The magnitude of pancreatic FA changes was an important factor influencing pancreatic endocrine and exocrine functions (Acosta-Montaño and García-González, 2018; Baynes et al, 2018;Kapica et al, 2018;Oh et al, 2018). Effects of pancreatic FA on insulin secretion and pancreatic β-cell survival are related to the degree ABSTRACT.…”

Section: Introductionmentioning

confidence: 99%

Enrichment of lamb rations with carnosic acid and seleno-compounds affects the content of selected lipids and tocopherols in the pancreas

Białek¹,

Karpińska²,

Czauderna³

2022

J. Anim. Feed Sci.

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Section: Introductionmentioning

confidence: 99%

Enrichment of lamb rations with carnosic acid and seleno-compounds affects the content of selected lipids and tocopherols in the pancreas

Białek¹,

Karpińska²,

Czauderna³

2022

J. Anim. Feed Sci.

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“…These hormones include ghrelin, obestatin, gastric leptin, apelin, and nesfatin-1 secreted by the stomach and intestines and released in small amounts from the endocrine pancreas [ 24 , 25 , 26 , 27 , 28 , 29 ]. As shown previously, these hormones can regulate the secretion of pancreatic juice [ 20 , 21 , 30 , 31 , 32 , 33 ]. These signals send feedback to the region of the central nervous system that controls energy balance [ 34 ].…”

Section: Discussionmentioning

confidence: 82%

“…In earlier studies, we found that the i.v. administration of exogenous ghrelin and apelin decreased [ 20 , 32 ], while obestatin stimulated pancreatic juice secretion [ 21 , 31 ]. The above-mentioned studies have also shown that the method of hormone administration plays an important role in its influence on the pancreas.…”

Section: Discussionmentioning

confidence: 99%

“…The anesthesia was maintained during the experiment by intraperitoneal administration of anesthetics, and rats’ body temperature was continuously monitored and maintained by heating lamps. The involvement of vagal nerves was examined following subdiaphragmatic vagotomy and capsaicin deafferentation, as described previously [ 20 , 21 ]. The Neuropack (Nihon Kohden Co., Tokyo, Japan) apparatus was used to stimulate the vagus nerve (rate, 1 Hz; duration, 0.2 ms; V-range, 2 mV; stim., 4.2 mA) [ 22 , 23 ].…”

Section: Methodsmentioning

confidence: 99%

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Effect of Adropin on Pancreas Exocrine Function in a Rat Model: A Preliminary Study

Kapica

Puzio

Abramowicz

et al. 2022

Animals

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The aim was to investigate the potential effect of adropin (ADR) on pancreatic–biliary juice (PBJ) secretion (volume, protein content, trypsin activity) in a rat model. The animals were divided into control and five experimental groups: adropin, CCK-8 (CCK-8 stimulation), capsaicin (capsaicin deactivation of afferents), vagotomy (vagotomy procedure), and vagal stimulation (vagal nerve stimulation). The experiment consisted of four phases, during which vehicle (0.9% NaCl) and three ADR boluses (5, 10, and 20 µg/kg BW) were administered i.v. every 30 min. PBJ samples were collected from each rat at 15 min intervals after boluses. Exogenous ADR failed to affect the pancreatic responses after vagotomy and the capsaicin pretreatment and reduced the PBJ volume, protein outputs, and trypsin activity in the adropin, CCK-8, and vagal stimulation groups in a dose-dependent manner. In all these groups, volume of PBJ was reduced only by the highest dose of ADR (p < 0.001 for adropin group and p < 0.01 for CCK-8 and vagal stimulation groups), and the protein outputs were reduced by the administration of ADR 10 µg/kg BW (adropin and CCK-8 groups, p < 0.01 in both cases) and 20 µg/kg BW (p < 0.001 for adropin and CCK-8 groups, p < 0.01 for vagal stimulation group). The 10 µg/kg BW dose of ADR reduced the trypsin output in the CCK-8 group (p < 0.01), and the highest ADR dose reduced the trypsin output in the CCK-8 (p < 0.001) and vagal stimulation (p < 0.01) groups. In conclusion, adropin in the analyzed doses exhibits the negative feedback pathway. This mechanism seems to participate in the regulation of pancreatic juice secretion via an indirect vagal mechanism.

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“…Secretin is released from enteroendocrine cells in the small intestine, and CCK is released from the duodenum and jejunum in the presence of lipids and proteins from ingested food. Kapica et al (2018) described the effect of obestatin (a hormone produced in specialized cells in the gastric and small intestine of many animals, including humans) on the exocrine pancreatic secretion in rats. They found that this hormone can stimulate the secretion of pancreatic juice through two opposing mechanisms.…”

Section: Influence Of the Exocrine Function Of The Pancreas On The De...mentioning

confidence: 99%

Pancreas—Its Functions, Disorders, and Physiological Impact on the Mammals’ Organism

Karpińska

Czauderna

2022

Front. Physiol.

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This review aimed to analyze the scientific literature on pancreatic diseases (especially exocrine pancreatic insufficiency). This review also describes the correlation between the physiological fitness of the pancreas and obesity. The influence of the pancreatic exocrine function on the development of the organism of adults and adolescents was also described. The results of piglet studies available in the literature were cited as an established model used to optimize treatments for pancreatic diseases in humans. The pancreas has an exocrine and hormonal function. Consequently, it is one of the key internal organs in animals and humans. Pancreatic diseases are usually severe and particularly troublesome. A properly composed diet and taken dietary supplements significantly improve the patient’s well-being, as well as the course of the disease. Therefore, a diet and a healthy lifestyle positively affect maintaining the optimal physiological efficiency of the pancreas.

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Exogenous obestatin affects pancreatic enzyme secretion in rat through two opposite mechanisms, direct inhibition and vagally-mediated stimulation

Cited by 5 publications

References 30 publications

Enrichment of lamb rations with carnosic acid and seleno-compounds affects the content of selected lipids and tocopherols in the pancreas

Enrichment of lamb rations with carnosic acid and seleno-compounds affects the content of selected lipids and tocopherols in the pancreas

Effect of Adropin on Pancreas Exocrine Function in a Rat Model: A Preliminary Study

Pancreas—Its Functions, Disorders, and Physiological Impact on the Mammals’ Organism

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