Exogenous Porcine Viruses

Paul, P. S.; Halbur, Patrick G.; Janke, Bruce H.; Joo, Heesoo; Nawagitgul, Porntippa; Singh, Jagir; Sorden, Steven D.

doi:10.1007/978-3-642-55541-1_6

Cited by 19 publications

(16 citation statements)

References 123 publications

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“…The resulting matrix is sufficiently acellular (Fig. 2) to obviate adverse host immune responses [35–38] and contagion such as virus transmission [47–49] while retaining bioactive molecules, including myelin and laminin (Fig. 3).…”

Section: Discussionmentioning

confidence: 99%

Biologic scaffolds composed of central nervous system extracellular matrix

et al. 2012

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Acellular biologic scaffolds are commonly used to facilitate the constructive remodeling of three of the four traditional tissue types: connective, epithelial, and muscle tissues. However, the application of extracellular matrix (ECM) scaffolds to neural tissue has been limited, particularly in the central nervous system (CNS) where intrinsic regenerative potential is low. The ability of decellularized liver, lung, muscle, and other tissues to support tissue-specific cell phenotype and function suggests that CNS-derived biologic scaffolds may help to overcome barriers to mammalian CNS repair. A method was developed to create CNS ECM scaffolds from porcine optic nerve, spinal cord, and brain, with decellularization verified against established criteria. CNS ECM scaffolds retained neurosupportive proteins and growth factors and, when tested with the PC12 cell line in vitro, were cytocompatible and stimulated proliferation, migration, and differentiation. Urinary bladder ECM (a non-CNS ECM scaffold) was also cytocompatible and stimulated PC12 proliferation but inhibited migration rather than acting as a chemoattractant over the same concentration range while inducing greater rates of PC12 differentiation compared to CNS ECM. These results suggest that CNS ECM may provide tissue-specific advantages in CNS regenerative medicine applications and that ECM scaffolds in general may aid functional recovery after CNS injury.

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Section: Discussionmentioning

confidence: 99%

Biologic scaffolds composed of central nervous system extracellular matrix

et al. 2012

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“…Typical paramyxoviruses that have been previously associated with PDB are canine distemper virus and measles virus. However, newly recognized paramyxoviruses have been associated with disease status in several animal species, including horses and swine (45–47) . Limited information is actually available on the public health risk of many of these exogenous paramyxoviruses, and reliable and rapid diagnostic tests are available for only a few of these viruses.…”

Section: Discussionmentioning

confidence: 99%

Characteristics and Familial Aggregation of Paget's Disease of Bone in Italy

Merlotti

Gennari

Galli

et al. 2005

Journal of Bone and Mineral Research

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Of the 147 PDB patients, 22 (15%) had at least one other family member affected, 19 (13%) reported one family member with suspected features of PDB, and 106 (72%) were classified as sporadic PDB. Even though we observed a reduced clinical severity of PDB with respect to other populations (mean number of affected sites, 2.2 +/- 1.6), we did not find any evidence of a decreased severity of the disease over time. We also found an association of PDB with animal contact (odds ratio [OR], 2.22; p < 0.0005) and a significant prevalence of PDB in rural versus urban districts (OR, 2.42; p < 0.0005). Osteoarthritis (45%), fractures (14%), hearing loss (14%), and valvular calcifications (15%) were the most observed complications. Interestingly, the geographical distribution of PDB showed a concentration of cases in rural areas of Campania and Tuscany. These areas may indicate local clustering of PDB cases in Italy, similar to that observed in other countries.

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“…Some of these viruses play an important role in the pathogenesis of bacterial infections (200,230,231). Pigs serve as a major reservoir of H1N1 and H3N2 influenza viruses and are frequently involved in interspecies transmission of influenza viruses (178). The major manifestations of these viruses include the following.…”

Section: Infectionmentioning

confidence: 99%

The porcine lung as a potential model for cystic fibrosis

Rogers¹,

Abraham²,

Brogden³

et al. 2008

American Journal of Physiology-Lung Cellular and Molecular Phys

224

219

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Airway disease currently causes most of the morbidity and mortality in patients with cystic fibrosis (CF). However, understanding the pathogenesis of CF lung disease and developing novel therapeutic strategies have been hampered by the limitations of current models. Although the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) has been targeted in mice, CF mice fail to develop lung or pancreatic disease like that in humans. In many respects, the anatomy, biochemistry, physiology, size, and genetics of pigs resemble those of humans. Thus pigs with a targeted CFTR gene might provide a good model for CF. Here, we review aspects of porcine airways and lung that are relevant to CF.

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Exogenous Porcine Viruses

Cited by 19 publications

References 123 publications

Biologic scaffolds composed of central nervous system extracellular matrix

Biologic scaffolds composed of central nervous system extracellular matrix

Characteristics and Familial Aggregation of Paget's Disease of Bone in Italy

The porcine lung as a potential model for cystic fibrosis

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