Exogenous surfactant application in a rat lung ischemia reperfusion injury model: effects on edema formation and alveolar type II cells

Dreyer, Niels; Mühlfeld, Christian; Fehrenbach, Antonia; Pech, Thomas; Berg, Sebastian von; Nagib, Ragi; Richter, Joachim; Wittwer, Thorsten; Wahlers, Thorsten; Ochs, Matthias

doi:10.1186/1465-9921-9-5

Cited by 21 publications

(21 citation statements)

References 46 publications

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“…Struber et al (191) used a nebulized synthetic surfactant for several patients with severe LIRI after lung transplantation, which led to rapid improvement in pulmonary compliance and extubation within 6 days after application. However, bronchoscopic administration appears to deliver the surfactant in the IR lung more accurately (55,98,102), and natural surfactants appear to be superior compared with synthetic surfactants used on neonates (98). The surfactant allows reduction in the inspired oxygen levels and ventilator settings, reducing the incidence of pneumothorax and increasing survival (98).…”

Section: H1292 Molecular Mechanisms Of Lung Ischemia-reperfusion Injurymentioning

confidence: 99%

“…ROS are generated as a result of the changes in membrane potential (32). In the lung, which has a secondary source of oxygen via ventilation (55), the ATP levels are preserved, so the cellular event triggering the generation of ROS production is the loss of shear stress in the endothelium, which is conveyed through increased NADPH oxidase activity (6) (see below).…”

Section: Mechanisms Of Lung Injury During Irmentioning

confidence: 99%

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Lung ischemia-reperfusion injury: a molecular and clinical view on a complex pathophysiological process

Hengst

Gielis

Lin

et al. 2010

American Journal of Physiology-Heart and Circulatory Physiology

324

280

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Lung ischemia-reperfusion injury remains one of the major complications after cardiac bypass surgery and lung transplantation. Due to its dual blood supply system and the availability of oxygen from alveolar ventilation, the pathogenetic mechanisms of ischemia-reperfusion injury in the lungs are more complicated than in other organs, where loss of blood flow automatically leads to hypoxia. In this review, an extensive overview is given of the molecular and cellular mechanisms that are involved in the pathogenesis of lung ischemia-reperfusion injury and the possible therapeutic strategies to reduce or prevent it. In addition, the roles of neutrophils, alveolar macrophages, cytokines, and chemokines, as well as the alterations in the cell-death related pathways, are described in detail. pulmonary; lung transplantation; ventilated ischemia IN THE PAST, THE LUNG WAS thought to be relatively resistant to ischemia because of its dual circulation and the availability of oxygen from alveolar ventilation. However, the depletion of lung oxygenation by stopping the ventilation leads to the same degree of lung impairment as a decrease in mechanotransduction by loss of blood flow, as determined by increases in vascular pressure and permeability (11), indicating that any deficiency from oxygenation or mechanotransduction can have significant repercussions (149).Reperfusion of the ischemic lung is a double-edged sword. Reestablishing the perfusion of the ischemic lung is absolutely required to maintain the viability of the lung, but reperfusion itself can trigger a complex cascade of events, the so-called pulmonary ischemia-reperfusion injury (LIRI) (48), characterized by increased microvascular permeability (Pvasc), increased pulmonary vascular resistance (PVR), pulmonary edema, impaired oxygenation, and pulmonary hypertension. Ischemia of the lung, without loss of ventilation, results in a complex pathophysiological situation and, therefore, is not comparable with ischemia in other organs. During ventilated ischemia, for example, the adenosine triphosphate (ATP) levels remain normal while reactive oxygen species (ROS) are formed (70), illustrating aspects of complexity of the pathophysiology of ventilated and anoxic lung ischemia. Therefore, a distinction should be made between ventilated ischemia, meaning a loss of blood flow, and anoxia/reoxygenation, indicating the loss of oxygenation and/or perfusion. In this review, the terms anoxia/reoxygenation and ventilated ischemia will be used, if the specific model is known and/or the mechanism is suggested to be model specific. Ischemia alone will be used, if it applies for both mechanisms, if the specific model is not known, or the research involves other organs.Complete and prolonged lung anoxia for up to several hours is unavoidable during lung transplantation, with dire consequences. Reperfusion of the transplanted lung can lead to nonspecific alveolar damage, pulmonary edema, and hypoxemia within 72 h after lung transplantation. Even with the advancements in lung preservati...

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Section: H1292 Molecular Mechanisms Of Lung Ischemia-reperfusion Injurymentioning

confidence: 99%

Section: Mechanisms Of Lung Injury During Irmentioning

confidence: 99%

Lung ischemia-reperfusion injury: a molecular and clinical view on a complex pathophysiological process

Hengst

Gielis

Lin

et al. 2010

American Journal of Physiology-Heart and Circulatory Physiology

324

280

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“…A lesão de IR após o transplante pulmonar é a principal causa de disfunção do órgão e está associada com inúmeras alterações estruturais e funcionais (Dreyer et al, 2008), como, por exemplo, edema intra-alveolar e intersticial e diminuição da integridade da barreira alvéolo-capilar (Novick et al, 1991;Mühlfeld et al, 2007;Dreyer et al, 2008).…”

Section: Lesão De Isquemia E Reperfusãounclassified

“…A lesão de IR, que pode ocorrer logo após o transplante pulmonar, é a principal causa de disfunção do enxerto e está associada com um alto índice de morbidade e mortalidade dos pacientes receptores nos primeiros dias após a cirurgia (Dreyer et al, 2008). Diversas alterações estruturais e funcionais estão entre as possíveis explicações para este fato, como, por exemplo, a diminuição da integridade da barreira alvéolo-capilar e o consequente edema intra-alveolar e intersticial (Novick et al, 1991;Mühlfeld et al, 2007;Dreyer et al, 2008).…”

Section: D Di Is Sc Cu Us Ss Sã ãO Ounclassified

“…Diversas alterações estruturais e funcionais estão entre as possíveis explicações para este fato, como, por exemplo, a diminuição da integridade da barreira alvéolo-capilar e o consequente edema intra-alveolar e intersticial (Novick et al, 1991;Mühlfeld et al, 2007;Dreyer et al, 2008). Por outro lado, a lesão de IR é marcadamente atenuada quando macrófagos alveolares estão reduzidos, o que ocorre, em grande parte, devido à redução da expressão das citocinas pró-inflamatórias e quimiocinas (Zhao et al, 2006 Hengst et al, 2010), resultando na adesão maciça de células inflamatórias, tais como, macrófagos, neutrófilos e células T, que estão conectadas a arteríolas, vênulas e capilares alveolares (Kuhnle et al, 1998;den Hengst et al, 2010).…”

Section: D Di Is Sc Cu Us Ss Sã ãO Ounclassified

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Efeitos da suplementação com creatina na lesão de isquemia e reperfusão após transplante pulmonar unilateral em ratos

Almeida¹

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EEf fe ei it to os s d da a s su up pl le em me en nt ta aç çã ão o c co om m c cr re ea at ti in na a n na a l le es sã ão o d de e i is sq qu ue em mi ia a e e r re ep pe er rf fu us sã ão o a ap pó ós s t tr ra an ns sp pl la an nt te e p pu ul lm mo on na ar r u un ni il la at te er ra al l e em m r ra at to os s Ao meu orientador Rogerio Pazetti por compartilhar sua experiência profissional comigo e por toda a confiança depositada em mim na última década.À CAPES e à FAPESP pelo apoio financeiro para a realização desta pesquisa. Muito obrigada!!!

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Lung Transplantation and the Blood–Gas Barrier

Schnapper

Ochs

2015

The Vertebrate Blood-Gas Barrier in Health and Disease

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Exogenous surfactant application in a rat lung ischemia reperfusion injury model: effects on edema formation and alveolar type II cells

Cited by 21 publications

References 46 publications

Lung ischemia-reperfusion injury: a molecular and clinical view on a complex pathophysiological process

Lung ischemia-reperfusion injury: a molecular and clinical view on a complex pathophysiological process

Efeitos da suplementação com creatina na lesão de isquemia e reperfusão após transplante pulmonar unilateral em ratos

Lung Transplantation and the Blood–Gas Barrier

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