Exogenous Transforming Growth Factor β2 Modulates Collagen I and Collagen III Synthesis in Proliferative Scar Xenografts in Nude Rats

Peripheral Blood Fibrocytes: Differentiation Pathway and Migration to Wound Sites

“…28). TGF-␤ significantly up-regulates collagen expression by dermal fibroblasts in vitro (29), by myofibroblasts (30), as well as by proliferative scar xenografts in vivo (31). Many laboratories have confirmed that TGF-␤ plays a role in the natural wound healing process and that TGF-␤ is expressed in rodent wound chambers during the early to mid phases (days 4 -7) of wound healing (32).…”

Oral administration of <I>Enterococcus faecal</I>is EC-12 cell preparation improves villous atrophy after weaning through enhancement of growth factor expression in mice

“…Some of the Fgf and the Pdgf family genes were also upregulated, to some extent, in the jejunal and the ileal LP by EC-12. These molecules are all known to induce the proliferation of epithelial cells, and many are involved in the morphoneogenesis of intestinal villi (19,29,30,33). The significant upregulation in Il-6 in the LP is interesting and suggests a possible role of EC-12 in the prevention of villous atrophy.…”

Dermal Transforming Growth Factor-β Responsiveness Mediates Wound Contraction and Epithelial Closure

“…[23][24][25][26][27] In examining collagen deposition in skin wounds, sections stained with Masson's trichrome suggested wounds on Tgfbr2 dermalKO mice had less collagen deposition at day 14 after wounding, compared with control mice ( Figure 3A). As a measure of collagen fiber orientation, wounds stained with picrosirius red were observed with polarized light microscopy.…”