Exogenous VEGF introduced by bioceramic composite materials promotes the restoration of bone defect in rabbits

Yu, Hedong; Zeng, Xian‐Tao; Deng, Cai; Shi, Congyu; Ai, Jun; Leng, Weidong

doi:10.1016/j.biopha.2017.12.075

Cited by 13 publications

(13 citation statements)

References 29 publications

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“…Only qualitative data extracted from each study were synthesized in analytic tables. In seven of the 13 included studies, New Zealand rabbits were used [16,[115][116][117][118][119][120], while six studies were conducted in rats, of which three used the Sprague-Dawley strain [17,121,122], two the Wistar strain [123,124] and one the Lewis strain [125]. The calvarial critical-sized defect was the most used model for assessing new bone formation (Table 3).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The calvarial critical-sized defect was the most used model for assessing new bone formation (Table 3). Two studies used bone marrow-derived mesenchymal stem cells (BMSCs) of different origins [17,115,120]. Interestingly, in none of those studies was the use of resorbable or non-resorbable membranes reported.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Notably, all the included studies reported uneventful healing outcomes and no relevant adverse reactions. Two studies reported on the use of polyether-ether-ketone/odontogenic biphasic bioceramic composites (PEEK-BBC) prepared via calcination for the treatment of mandibular bone defects [16,115]. Porous PEEK-BBC composites were found to promote bone healing in vivo, potentially via the upregulation of bone morphogenetic protein-2 (BMP-2), as suggested by the higher mRNA and protein expression levels of BMP-2 in the presence of PEEK-BBC composites, than in bone defects left empty [16].…”

Section: Studies In Rabbits-main Featuresmentioning

confidence: 99%

“…Porous PEEK-BBC composites were found to promote bone healing in vivo, potentially via the upregulation of bone morphogenetic protein-2 (BMP-2), as suggested by the higher mRNA and protein expression levels of BMP-2 in the presence of PEEK-BBC composites, than in bone defects left empty [16]. Moreover, when vascular endothelial growth factor (VEGF) was encapsulated into PEEK-BBC composites, a relative upregulation of VEGF at 8 and 16 weeks of healing was observed compared to jaw defects left empty [115]. However, the specific effect of the exogenous VEGF, itself, encapsulated in the PEEK-BBC composites, could not be determined, due to the absence [115] of a control group treated with PEEK-BBC alone.…”

Section: Studies In Rabbits-main Featuresmentioning

confidence: 99%

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The Impact of Bioceramic Scaffolds on Bone Regeneration in Preclinical In Vivo Studies: A Systematic Review

et al. 2020

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Bioceramic scaffolds are appealing for alveolar bone regeneration, because they are emerging as promising alternatives to autogenous and heterogenous bone grafts. The aim of this systematic review is to answer to the focal question: in critical-sized bone defects in experimental animal models, does the use of a bioceramic scaffolds improve new bone formation, compared with leaving the empty defect without grafting materials or using autogenous bone or deproteinized bovine-derived bone substitutes? Electronic databases were searched using specific search terms. A hand search was also undertaken. Only randomized and controlled studies in the English language, published in peer-reviewed journals between 2013 and 2018, using critical-sized bone defect models in non-medically compromised animals, were considered. Risk of bias assessment was performed using the SYRCLE tool. A meta-analysis was planned to synthesize the evidence, if possible. Thirteen studies reporting on small animal models (six studies on rats and seven on rabbits) were included. The calvarial bone defect was the most common experimental site. The empty defect was used as the only control in all studies except one. In all studies the bioceramic materials demonstrated a trend for better outcomes compared to an empty control. Due to heterogeneity in protocols and outcomes among the included studies, no meta-analysis could be performed. Bioceramics can be considered promising grafting materials, though further evidence is needed.

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Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Studies In Rabbits-main Featuresmentioning

confidence: 99%

Section: Studies In Rabbits-main Featuresmentioning

confidence: 99%

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The Impact of Bioceramic Scaffolds on Bone Regeneration in Preclinical In Vivo Studies: A Systematic Review

et al. 2020

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“…Moreover, the application of a VEGF alginate hydrogel on top of a GBR membrane significantly increased bone density and bone area/tissue area compared to the membrane alone in rat calvarial CSDs (Kaigler et al., ). The potential of VEGF to accelerate bone formation when added to a polyether ketone (PEK)/biphasic bioceramic composite material was demonstrated in rabbit mandibular defects (Yu, Zeng, Deng, Shi & Ai, ).…”

Section: Resultsmentioning

confidence: 99%

The use of bioactive factors to enhance bone regeneration: A narrative review

Donos

Dereka

Calciolari

2019

J Clinic Periodontology

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Aim This review critically appraises the available knowledge on the pre‐clinical and clinical use of bioactive factors for bone regeneration in the cranial and maxillofacial area. Materials and Methods The use of growth factors, amelogenins and autologous platelet concentrates (APCs) for bone regeneration was reviewed in a systematic manner. More specifically, pre‐clinical and clinical studies on ridge preservation, alveolar ridge augmentation, regeneration of peri‐implant defects and sinus augmentation models were considered. Results Amongst different bioactive factors, the highest pre‐clinical and clinical evidence of a positive effect on bone formation is associated with rhBMP‐2 and the lowest with amelogenins. While APCs seem to accelerate clinical healing and reduce postoperative discomfort, there is insufficient and contrasting evidence of a significant effect on hard tissue regeneration for the different clinical applications. Conclusions Although there is increasing evidence that bioactive factors might enhance the bone regeneration process, the great heterogeneity of the available studies and the limited number of RCTs do not allow to draw robust conclusions. Issues that still need to be investigated include the optimal carriers for bioactive agents (direct vs. indirect), the dosage, the timing of administration, as well as the possibility of combining different agents to promote synergistic effects.

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Bone‐Induced Nanocomposite Coating with a “Sandwich” Structure

Guan,

Zou,

osman

et al. 2024

Adv Materials Inter

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Infection‐induced bone defects present significant challenges in clinical bone regeneration, frequently leading to poor bone induction, recurring infections, and complications such as pain and chronic inflammation. This study introduces a novel Ti/Lignin‐Ag@PLL composite coating with a “sandwich” structure, designed to integrate pro‐adhesion, photothermal‐photodynamic antibacterial, and osteogenic properties. The Ti/Lignin‐Ag@PLL composite coating is fabricated using self‐assembly technology, in which Ag+ is reduced to silver nanoparticles (Ag‐NPs) by lignin, followed by Polylysine (PLL) grafting. Photothermal conversion efficiency is evaluated under near‐infrared (NIR) laser irradiation, while antibacterial activity is tested against E. coli and S. aureus. Biocompatibility is also assessed using vascular endothelial cells (VECs) and osteoblasts (OBs). The results indicate that the Ti/Lignin‐Ag@PLL coating demonstrates a 31% photothermal conversion efficiency and nearly 100% antibacterial efficacy against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) under NIR irradiation for 10 min. Without irradiation, the antibacterial rates are 85% and 94%, respectively, after 24 h. Additionally, the coating significantly promotes cell adhesion, proliferation, and osteogenesis, as evidenced by the upregulation of Runx2 and Collagen I. This study uniquely contributes to the development of a multifunctional composite coating that effectively combines robust antibacterial properties with enhanced osteogenic potential, offering a promising solution for bone tissue repair and infection prevention.

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Exogenous VEGF introduced by bioceramic composite materials promotes the restoration of bone defect in rabbits

Cited by 13 publications

References 29 publications

The Impact of Bioceramic Scaffolds on Bone Regeneration in Preclinical In Vivo Studies: A Systematic Review

The Impact of Bioceramic Scaffolds on Bone Regeneration in Preclinical In Vivo Studies: A Systematic Review

The use of bioactive factors to enhance bone regeneration: A narrative review

Bone‐Induced Nanocomposite Coating with a “Sandwich” Structure

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